TUMIC
An integrated concept of tumor metastasis: implications for therapy
| Coordinatore | RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Organization address
address: SEMINARSTRASSE 2 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://itgmv1.fzk.de/www/tumic/tumic_main.htm |
| Totale costo | 4˙180˙192 € |
| EC contributo | 2˙999˙185 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-04-01 - 2012-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Organization address
address: SEMINARSTRASSE 2 contact info |
DE (HEIDELBERG) | coordinator | 0.00 |
| 2 |
ACTELION PHARMACEUTICALS LTD
Organization address
address: GEWERBESTRASSE 16 contact info |
CH (ALLSCHWIL) | participant | 0.00 |
| 3 |
CANCER RESEARCH UK
Organization address
address: ST JOHN STREET 407 ANGEL BUILDING contact info |
UK (LONDON) | participant | 0.00 |
| 4 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 0.00 |
| 5 |
FONDATION DU CENTRE PLURIDISCIPLINAIRE D'ONCOLOGIE
Organization address
address: RUE DU BUGNON 46 contact info |
CH (LAUSANNE) | participant | 0.00 |
| 6 |
FORSCHUNGSZENTRUM KARLSRUHE GMBH
Organization address
address: Weberstrasse 5 contact info |
DE (KARLSRUHE) | participant | 0.00 |
| 7 |
INSTITUT CURIE
Organization address
address: 26, rue d'Ulm contact info |
FR (PARIS) | participant | 0.00 |
| 8 |
KRAEFTENS BEKAEMPELSE
Organization address
address: Strandboulevarden 49 contact info |
DK (KOEBENHAVN) | participant | 0.00 |
| 9 |
STICHTING HET NEDERLANDS KANKER INSTITUUT
Organization address
address: PLESMANLAAN 121 contact info |
NL (AMSTERDAM) | participant | 0.00 |
| 10 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 0.00 |
| 11 |
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Organization address
address: Corso Umberto I 40 contact info |
IT (NAPOLI) | participant | 0.00 |
| 12 |
UNIVERSITAET BASEL
Organization address
address: Petersplatz 1 contact info |
CH (BASEL) | participant | 0.00 |
| 13 |
UNIVERSITE DE FRIBOURG
Organization address
address: AVENUE DE L'EUROPE 20 contact info |
CH (FRIBOURG) | participant | 0.00 |
| 14 |
VIB
Organization address
address: Rijvisschestraat 120 contact info |
BE (ZWIJNAARDE - GENT) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'From many perspectives our concept of the process of metastasis is inadequate and needs to be revised. In particular, the potential impact of recent ideas about the cellular basis of tumor growth (cancer stem cells) and the establishment by remote tumors of special permissive microenvironments in target organs prior to metastasis (metastatic niches) remains to be explored. In the TuMIC project we will use novel experimental approaches to integrate these newly emerging principles and ideas with the different hypotheses that have until now tried to explain the process of metastasis. Specifically we aim to understand how cancer stem cells behave in and contribute to metastasis, and how networks and pathways that are known to regulate metastasis affect their properties. Further objects are to determine how a permissive microenvironment for metastasis formation is established in given organs, how this contributes to determining patterns of metatasis, and how these microenvironments interact with cancer stem cells. These studies will facilitate the development of an improved and more accurate concept about the process of metastasis. In turn, this will have fundamental ramifications for the way in which novel anti-cancer therapies are designed, and most importantly should provide important new insights into how cancer and in particular metastatic disease can be successfully treated. With this in mind we will also perform preclinical studies that build on TuMIC findings with the aim of developing novel anti-cancer therapies.'
Introduzione (Teaser)
Despite extensive research, there are many issues regarding cancer biology that remain enigmatic. A European collaborative effort set out to explore the role of cancer stem cells (CSCs) and of the microenvironment on the process of tumour metastasis, while providing new potential targets for therapy.