TUMIC

An integrated concept of tumor metastasis: implications for therapy

 Coordinatore RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

 Organization address address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Dr.
Nome: Norbert
Cognome: Huber
Email: send email
Telefono: +49 6221 54 2157
Fax: +49 6221 54 3599

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://itgmv1.fzk.de/www/tumic/tumic_main.htm
 Totale costo 4˙180˙192 €
 EC contributo 2˙999˙185 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2012-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

 Organization address address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Dr.
Nome: Norbert
Cognome: Huber
Email: send email
Telefono: +49 6221 54 2157
Fax: +49 6221 54 3599

DE (HEIDELBERG) coordinator 0.00
2    ACTELION PHARMACEUTICALS LTD

 Organization address address: GEWERBESTRASSE 16
city: ALLSCHWIL
postcode: 4123

contact info
Titolo: Dr.
Nome: Urs
Cognome: Regenass
Email: send email
Telefono: -5658156
Fax: -5658922

CH (ALLSCHWIL) participant 0.00
3    CANCER RESEARCH UK

 Organization address address: ST JOHN STREET 407 ANGEL BUILDING
city: LONDON
postcode: EC1V 4AD

contact info
Titolo: Ms.
Nome: Kate
Cognome: Malfroy
Email: send email
Telefono: +44 01223 404202
Fax: 01223 404573

UK (LONDON) participant 0.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Ms.
Nome: Marieke
Cognome: Bootsma
Email: send email
Telefono: +31 (0)10 7044490
Fax: Fax:+31 (0)10 7044450

NL (ROTTERDAM) participant 0.00
5    FONDATION DU CENTRE PLURIDISCIPLINAIRE D'ONCOLOGIE

 Organization address address: RUE DU BUGNON 46
city: LAUSANNE
postcode: 1011

contact info
Titolo: Ms.
Nome: Chantal
Cognome: Vonlanthen-Clerc
Email: send email
Telefono: +41-21 314 02 15
Fax: +41-21 314 01 73

CH (LAUSANNE) participant 0.00
6    FORSCHUNGSZENTRUM KARLSRUHE GMBH

 Organization address address: Weberstrasse 5
city: KARLSRUHE
postcode: 76133

contact info
Titolo: Ms.
Nome: Anke
Cognome: Schmidt
Email: send email
Telefono: -830500
Fax: -834500

DE (KARLSRUHE) participant 0.00
7    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Ms.
Nome: Corinne
Cognome: Cumin
Email: send email
Telefono: +33 1 42-34-66-20
Fax: -+ 33 1 42-34-66-27

FR (PARIS) participant 0.00
8    KRAEFTENS BEKAEMPELSE

 Organization address address: Strandboulevarden 49
city: KOEBENHAVN
postcode: 2100

contact info
Titolo: Mr.
Nome: David
Cognome: Mollerup
Email: send email
Telefono: -35257245
Fax: -35257676

DK (KOEBENHAVN) participant 0.00
9    STICHTING HET NEDERLANDS KANKER INSTITUUT

 Organization address address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX

contact info
Titolo: Ms.
Nome: Jantien
Cognome: Mandres
Email: send email
Telefono: +31 20 512 2370
Fax: +31 20 512 2994

NL (AMSTERDAM) participant 0.00
10    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Edna
Cognome: Murphy
Email: send email
Telefono: 441223000000
Fax: 441223000000

UK (CAMBRIDGE) participant 0.00
11    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.

 Organization address address: Corso Umberto I 40
city: NAPOLI
postcode: 80138

contact info
Titolo: Prof.
Nome: Massimo
Cognome: Zollo
Email: send email
Telefono: 390814000000
Fax: 390814000000

IT (NAPOLI) participant 0.00
12    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Gerhard
Cognome: Christofori
Email: send email
Telefono: 0041 61 267 3562
Fax: 0041 61 267 3566

CH (BASEL) participant 0.00
13    UNIVERSITE DE FRIBOURG

 Organization address address: AVENUE DE L'EUROPE 20
city: FRIBOURG
postcode: 1700

contact info
Titolo: Ms.
Nome: Monique
Cognome: Bersier
Email: send email
Telefono: +41 26 300 7003
Fax: +41 26 300 9600

CH (FRIBOURG) participant 0.00
14    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Wim
Cognome: Goemaere
Email: send email
Telefono: 0
Fax: +32/9/2446610*

BE (ZWIJNAARDE - GENT) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

therapies    tumic    ideas    permissive    organs    microenvironment    anti    metastatic    cells    cancer    microenvironments    stem    metastasis   

 Obiettivo del progetto (Objective)

'From many perspectives our concept of the process of metastasis is inadequate and needs to be revised. In particular, the potential impact of recent ideas about the cellular basis of tumor growth (cancer stem cells) and the establishment by remote tumors of special permissive microenvironments in target organs prior to metastasis (metastatic niches) remains to be explored. In the TuMIC project we will use novel experimental approaches to integrate these newly emerging principles and ideas with the different hypotheses that have until now tried to explain the process of metastasis. Specifically we aim to understand how cancer stem cells behave in and contribute to metastasis, and how networks and pathways that are known to regulate metastasis affect their properties. Further objects are to determine how a permissive microenvironment for metastasis formation is established in given organs, how this contributes to determining patterns of metatasis, and how these microenvironments interact with cancer stem cells. These studies will facilitate the development of an improved and more accurate concept about the process of metastasis. In turn, this will have fundamental ramifications for the way in which novel anti-cancer therapies are designed, and most importantly should provide important new insights into how cancer and in particular metastatic disease can be successfully treated. With this in mind we will also perform preclinical studies that build on TuMIC findings with the aim of developing novel anti-cancer therapies.'

Introduzione (Teaser)

Despite extensive research, there are many issues regarding cancer biology that remain enigmatic. A European collaborative effort set out to explore the role of cancer stem cells (CSCs) and of the microenvironment on the process of tumour metastasis, while providing new potential targets for therapy.

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