MISMATCH2MODEL

Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance

 Coordinatore  

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Dr.
Nome: Rini
Cognome: De Crom
Email: send email
Telefono: -7043438
Fax: -7044722

 Nazionalità Coordinatore Non specificata
 Totale costo 3˙930˙000 €
 EC contributo 3˙000˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-11-01   -   2012-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Dr.
Nome: Rini
Cognome: De Crom
Email: send email
Telefono: -7043438
Fax: -7044722

NL (ROTTERDAM) coordinator 0.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Liliane
Cognome: Flabbée
Email: send email
Telefono: -42349422
Fax: -42349476

FR (PARIS) participant 0.00
3    JUSTUS-LIEBIG-UNIVERSITAET GIESSEN

 Organization address address: Ludwigstrasse 23
city: GIESSEN
postcode: 35390

contact info
Titolo: Prof.
Nome: Peter
Cognome: Friedhoff
Email: send email
Telefono: -9935999
Fax: -9936001

DE (GIESSEN) participant 0.00
4 KOBENHAVNS UNIVERSITET DK participant 0.00
5    STICHTING HET NEDERLANDS KANKER INSTITUUT

 Organization address address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX

contact info
Titolo: Dr.
Nome: Henri
Cognome: Van Luenen
Email: send email
Telefono: -5122086
Fax: -6691372

NL (AMSTERDAM) participant 0.00
6    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Josef
Cognome: Jiricny
Email: send email
Telefono: -6353453
Fax: -6353487

CH (ZURICH) participant 0.00

Mappa


ATTENZIONE, ERRORE, contatta Fabio e segnala queta pagina, grazie!

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

model    colon    mmr    quantitative    mismatch    multidisciplinary    data    genomic    cancer    expertise    hnpcc    structural    steps    msh    maintenance    dna    combine    modeling    complexity    single    stability    repair    levels   

 Obiettivo del progetto (Objective)

'Mismatch2model: Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability. In both bacteria and eukaryotes, the loss of mismatch repair gives rise to a mutator phenotype. In hereditary non-polyposis colon cancer (HNPCC) families, germline mutations in one MSH2, MSH6 or MLH1 allele predispose to cancer of the colon, endometrium, ovary and other organs. HNPCC is the most frequent form of familiar cancer. In the mismatch2model project we adopt and exploit a systems biology approach in which we combine Europe’s expertise in DNA mismatch repair with sophisticated multidisciplinary technology and expertise in quantitative modeling in order to describe this DNA repair process at different levels of complexity. The multidisciplinary consortium will have the following tasks that relate directly to the topics raised in Call HEALTH 2.1.2.5: - Gather quantitative and structural data sets describing the principal steps of DNA mismatch repair - Integrate and analyze structural and functional data obtained from single molecule and bulk studies - Develop mathematical models for single and/or multiple steps of the MMR pathway - Perform analyses at different levels of complexity: from recognition of the mismatch through repairosome assembly to in vivo function - Combine the well-understood MMR E.coli model system with the cancer-protective human system The combination of the individual strengths of the multidisciplinary groups involved in this program ensures that significant progress will be made towards the understanding of this complex process.'


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