EFRAIM

Mechanisms of early protective exposures on allergy development

 Coordinatore LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Erika
Cognome: Von Mutius
Email: send email
Telefono: +49 89 51602709
Fax: +49 89 5160 4452

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.efraim-online.com
 Totale costo 3˙915˙718 €
 EC contributo 2˙988˙000 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-1
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-02-01   -   2012-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Erika
Cognome: Von Mutius
Email: send email
Telefono: +49 89 51602709
Fax: +49 89 5160 4452

DE (MUENCHEN) coordinator 0.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Mr.
Nome: Yves
Cognome: Le Ray
Email: send email
Telefono: +33 1 60872506
Fax: +33 1 60872513

FR (PARIS 15) participant 0.00
3    KARDINAL SCHWARZENBERG'SCHES KRANKENHAUS BETRIEBSGESELLSCHAFT MBH

 Organization address address: Kardinal Schwarzenbergstrasse 2-6
city: SCHWARZACH
postcode: 5620

contact info
Titolo: Mr.
Nome: Karl
Cognome: Obermaier
Email: send email
Telefono: +43 6415 7101 2206
Fax: +43 6415 7101 2207

AT (SCHWARZACH) participant 0.00
4    MEDIZINISCHE HOCHSCHULE HANNOVER

 Organization address address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625

contact info
Titolo: Mr.
Nome: Michael
Cognome: Born
Email: send email
Telefono: +49 511 532 65 13
Fax: +49 511 532 85 04

DE (HANNOVER) participant 0.00
5    PHILIPPS UNIVERSITAET MARBURG

 Organization address address: Biegenstrasse 10
city: MARBURG
postcode: 35032

contact info
Titolo: Prof.
Nome: Harald
Cognome: Renz
Email: send email
Telefono: +49 6421 28 66234
Fax: +49 6421 28 65594

DE (MARBURG) participant 0.00
6    Protectimmun GmbH

 Organization address address: Uckendorfer Strasse 237e
city: Gelsenkirchen
postcode: 45886

contact info
Titolo: Dr.
Nome: Marion
Cognome: Kauth
Email: send email
Telefono: +49 234 36916714
Fax: +49 234 5886663

DE (Gelsenkirchen) participant 0.00
7    TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY

 Organization address address: Oak Park
city: CARLOW

contact info
Titolo: Mr.
Nome: Mark
Cognome: Ryan
Email: send email
Telefono: +353 25 42216
Fax: +353 25 42340

IE (CARLOW) participant 0.00
8    TECHNISCHE UNIVERSITAET MUENCHEN

 Organization address address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333

contact info
Titolo: Ms.
Nome: Ulrike
Cognome: Ronchetti
Email: send email
Telefono: +49 89 289 22616
Fax: +49 89 289 22620

DE (MUENCHEN) participant 0.00
9    TERVEYDEN JA HYVINVOINNIN LAITOS

 Organization address address: MANNERHEIMINTIE 166
city: HELSINKI
postcode: 300

contact info
Nome: Unknown
Cognome: Unknown
Email: send email
Telefono: +32 123456

FI (HELSINKI) participant 0.00
10    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Charlotte
Cognome: Braun-Fahrländer
Email: send email
Telefono: +41 61 270 22 20
Fax: +41 61 270 22 25

CH (BASEL) participant 0.00
11    UNIVERSITAET BERN

 Organization address address: Hochschulstrasse 4
city: BERN
postcode: 3012

contact info
Titolo: Prof.
Nome: Urs
Cognome: Frey
Email: send email
Telefono: +41 31 632 9353
Fax: +41 31 632 9484

CH (BERN) participant 0.00
12    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: +49 731 500 66397
Fax: +49 371 500 66392

DE (ULM) participant 0.00
13    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Dr.
Nome: Roger
Cognome: Lauener
Email: send email
Telefono: +44 44 266 73 05
Fax: +44 44 266 71 56

CH (ZURICH) participant 0.00
14    UNIVERSITE DE FRANCHE-COMTE

 Organization address address: CLAUDE GOUDIMEL 1
city: BESANCON
postcode: 25030

contact info
Titolo: Ms.
Nome: Pauline
Cognome: Fournier
Email: send email
Telefono: +33 3 81665814
Fax: +33 3 81501103

FR (BESANCON) participant 0.00
15    UNIVERSITEIT UTRECHT

 Organization address address: Heidelberglaan 8
city: UTRECHT
postcode: 3584 CS

contact info
Titolo: Ms.
Nome: Monique
Cognome: Hoek Van Der
Email: send email
Telefono: +31 30 253 3566
Fax: +31 30 253 7997

NL (UTRECHT) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cohorts    protective    birth    preventive    disease    mechanisms    life    onset    allergy    exposures    countries    environmental    allergic    efraim    allergies    illnesses   

 Obiettivo del progetto (Objective)

'Allergy has developed into a major health concern in Europe. Allergic diseases can currently be managed effectively but not cured. The onset of allergies stars early in life and there is increasing evidence that exogenous factors affecting the incidence of these illnesses exert their effect early in life, in part even prenatally. The highly interdisciplinary EFRAIM project will prospectively investigate the main protective factors in early life influencing the development of allergies in birth cohorts conducted in allergy protective environments in five European countries. These birth cohorts have been enrolling over 1,000 children and have collected detailed information on the onset of allergic illnesses, objective measures of allergies and a vast amount of information about a number of environmental exposures. Large biobanks with a variety of biological samples have been established. In the EFRAIM project particular attention will be given to the potential role of dietary exposures, lifestyle and other environmental (e.g. microbial) exposures early in life which are causal determinants rather than triggers of the illness. The mechanisms mediating these protective exposures such as the maturation of immune responses, gut colonisation, the mucosal barrier function and the genetic and epigenetic factors interacting with the environmental exposures will be investigated. The knowledge about protective exposures early in life can be turned into the development of preventive strategies. The EFRAIM project will actively address two routes of preventive interventions in animal models and in vitro studies: the development of an allergy protective milk formula and the development of an allergy vaccine. Both approaches are based on knowledge gained in the human studies. The EFRAIM project is expected to produce ground-breaking new insights on protective agents and their mechanisms that can be used to prevent the further development of allergies.'

Introduzione (Teaser)

Understanding the protective factors that influence the development of allergies in early life and the mechanisms by which they are mediated will help combat allergic disease. Through a study in rural areas in five European countries, the Efraim project draws a picture of how the environment can shape disease fate.

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