SUMO AND CHROMATIN

Regulating nuclear organisation in telomere maintenance and DNA repair: the role of SUMO modification

 Coordinatore Novartis Forschungsstiftung 

 Organization address address: Maulbeerstrasse 66
city: BASEL
postcode: 4058

contact info
Titolo: Prof.
Nome: Susan
Cognome: Gasser
Email: send email
Telefono: -6975045
Fax: -6973996

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 179˙297 €
 EC contributo 179˙297 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-2-1-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-03-01   -   2010-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Novartis Forschungsstiftung

 Organization address address: Maulbeerstrasse 66
city: BASEL
postcode: 4058

contact info
Titolo: Prof.
Nome: Susan
Cognome: Gasser
Email: send email
Telefono: -6975045
Fax: -6973996

CH (BASEL) coordinator 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cycle    dynamics    telomere    model    regulator    evidence    cancer    organism    localisation    modification    architecture    suggests    implicated    pathways    sumo    proteins    chromatin    budding    recent    maintenance    global    dna    saccharomyces    cell    yeast    regulates    telomeres    organisation    nuclear    sumoylation    addition    human    anchoring    cerevisiae    cells    mechanism    structure    transcription    genome    repair    vivo   

 Obiettivo del progetto (Objective)

'The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair. Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in vivo, we aim to elucidate the mechanism by which SUMO modification regulates these processes.'

Introduzione (Teaser)

Chromatin structure is known to be important in gaining access to DNA. Research can now reveal that the location of chromatin is equally important.

Descrizione progetto (Article)

Since chromatin is crucial to determining when and where DNA can be accessed, it is also important in nuclear processes such as DNA transcription and repair. Recent evidence has shown sumoylation to be an important regulator of the global nuclear architecture of cells. In addition, it has been implicated in processes such as telomere maintenance. Telomeres contain a specialised chromatin structure that ultimately protects against the disruption of a cell cycle or genome make-up.

The SUMO and chromatin project uses Saccharomyces cerevisiae (budding yeast) as a model organism to study nuclear dynamics in vivo. The research team aims to throw light on the mechanism by which SUMO modification regulates these processes. In budding yeast, telomeres are reversibly bound to the periphery of the nucleus. The organisation of chromatin is thought to be especially important for telomeres, where evidence suggests that altered nuclear localisation and dynamics can result in an inappropriate repair response.

Telomere anchoring in S. cerevisiae takes place along two partially redundant genetic pathways. The influence of these pathways changes throughout the cell cycle and also from telomere to telomere. In addition, since several proteins are implicated in telomere anchoring, the SUMO and chromatin project partners have hypothesised that the modification of SUMO (small ubiquitin-like modifier) may impact telomere anchoring.

Research so far suggests that SUMO modification impacts on telomere maintenance by affecting telomere localisation. In human cancer cells, where there is significant telomere misregulation, maintenance is driven by the sumoylation of telomere-binding proteins. Therefore, the use of a simplified system like budding yeast to gain a deeper mechanistic understanding of these processes could prove beneficial in the treatment of human diseases such as cancer.

Altri progetti dello stesso programma (FP7-PEOPLE)

CAREWORKFAMILYMARKET (2009)

"Between Family and Market: The Legal Regulation of Household Care Work in Globalizing Economies: Housewivery, Domestic Work, and Sex Work"

Read More  

STEMAGE (2013)

Towards an unbiased view of the role of stellar mass in galaxy evolution

Read More  

DYNAMIT (2013)

"Dynamics of transporters dependent on ubiquitin in plants : mechanisms, roles in plant nutrition and beyond"

Read More