PEPLASER

Combinatorial synthesis of peptide arrays with a laser printer

 Coordinatore Karlsruher Institut fuer Technologie 

 Organization address address: Kaiserstrasse 12
city: Karlsruhe
postcode: 76131

contact info
Nome: Natascha
Cognome: Wallburg
Email: send email
Telefono: +49 7247 825414
Fax: +49 7247 825403

 Nazionalità Coordinatore Germany [DE]
 Totale costo 4˙028˙614 €
 EC contributo 2˙988˙450 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-TP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2011-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Karlsruher Institut fuer Technologie

 Organization address address: Kaiserstrasse 12
city: Karlsruhe
postcode: 76131

contact info
Nome: Natascha
Cognome: Wallburg
Email: send email
Telefono: +49 7247 825414
Fax: +49 7247 825403

DE (Karlsruhe) coordinator 313˙766.70
2    AKAtech Produktions- und Handels GmbH

 Organization address city: Frankenmarkt
postcode: 4890

contact info
Titolo: Mr.
Nome: Michael
Cognome: Farthofer
Email: send email
Telefono: +43 7684 8804 112
Fax: +43 7684 8804-9

AT (Frankenmarkt) participant 600˙000.00
3    KMS Automation GmbH

 Organization address address: Im Webertal 20
city: Schramberg-Waldmoesssingen
postcode: 78713

contact info
Titolo: Mr.
Nome: Joachim
Cognome: Schullerer
Email: send email
Telefono: +49 7402 9306 131
Fax: +49 7402 9306 110

DE (Schramberg-Waldmoesssingen) participant 550˙610.00
4    FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V

 Organization address address: Hansastrasse 27C
city: MUENCHEN
postcode: 80686

contact info
Titolo: Mr.
Nome: Walter
Cognome: Krause
Email: send email
Telefono: -12052753
Fax: -12057574

DE (MUENCHEN) participant 300˙000.00
5    UPPER AUSTRIAN RESEARCH GMBH

 Organization address address: Hafenstrasse 47-51
city: Linz
postcode: 4020

contact info
Titolo: Dr.
Nome: Alois
Cognome: Sonnleitner
Email: send email
Telefono: +43 732 606079 24

AT (Linz) participant 298˙800.00
6    BIOINFOBANK INSTITUTE

 Organization address address: Limanowskiego 24/a 16
city: POZNAN
postcode: 60744

contact info
Titolo: Dr.
Nome: Leszek
Cognome: Rychlewski
Email: send email
Telefono: +48 604 628805
Fax: +48 61 8643350

PL (POZNAN) participant 180˙000.00
7    MICROSYSTEMS LTD

 Organization address address: kv. CHAIKA 15-D-21
city: Varna
postcode: 9010

contact info
Titolo: Mr.
Nome: Nikolay
Cognome: Nikolov
Email: send email
Telefono: +359 52 321998
Fax: +359 52 302534

BG (Varna) participant 150˙000.00
8    TECHNICAL UNIVERSITY OF VARNA

 Organization address address: Studentska 1
city: VARNA
postcode: 9010

contact info
Titolo: Dr.
Nome: Peycho
Cognome: Popov
Email: send email
Telefono: +359 52 383385
Fax: +359 52 302 771

BG (VARNA) participant 150˙000.00
9    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Ms.
Nome: Bettina
Cognome: Crispin
Email: send email
Telefono: +49 6221-42-2700
Fax: +49 6221-42-2708

DE (HEIDELBERG) participant 145˙233.31
10    AIMS Scientific Products GmbH

 Organization address city: Braunschweig
postcode: 38124

contact info
Titolo: Dr.
Nome: Norbert
Cognome: Zander
Email: send email
Telefono: +49 5 31 87 60 49 40
Fax: +49 531 87 60 49 49

DE (Braunschweig) participant 100˙080.00
11    PEPperPRINT GmbH

 Organization address address: Schlossweg 9
city: Wiesloch
postcode: 69168

contact info
Titolo: Dr.
Nome: Volker
Cognome: Stadler
Email: send email
Telefono: +49 6202 574679
Fax: +49 6222 53301

DE (Wiesloch) participant 100˙000.00
12    Selvita spolka z ograniczona odpowiedzialnoscia

 Organization address address: ul. Gersona 2
city: KRAKOW
postcode: 30818

contact info
Titolo: Ms.
Nome: Justyna
Cognome: Supel
Email: send email
Telefono: +48 12 410 73 80
Fax: +48 12 410 73 82

PL (KRAKOW) participant 99˙960.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

complexity    particles    machines    arrays    amino    paradigmatic    wp    million    prototype    peptides    acid    laser    peptide    us    output    printer    examples    readout    toners   

 Obiettivo del progetto (Objective)

'Our particle-based method allows us to synthesise high complexity peptide arrays by combinatorial synthesis and for an unrivalled prize. We plan to further develop this new technology up to the level of robust prototype machines, and mate it to bioinformatics and readout tools. Together, our procedure(s) should boost the field of proteomics in a similar way as the lithographic technologies did with the field of genomics. Central to our novel method are the activated chemical building blocks that are “frozen” within solid amino acid particles. Thereby, we can use a colour laser printer to send them to defined addresses on a 2D support, where the particles are simply melted to induce a spatially defined coupling reaction of now freed amino acid derivatives. By repeated printing and melting cycles this simple trick yields high complexity peptide arrays. Based on existing pre-prototypes, we will develop a user-friendly peptide laser printer that spatially defined addresses our 20 different amino acid toners in high resolution to a support (WP1), and a scanner that especially fast and sensitive reads out the large formats delivered by the peptide laser printer (WP2). The increased production of amino acid toners and array supports are other bottlenecks in the output of peptide arrays that are tackled in WP3. This should allow us to increase the output of individual peptide spots from currently 0,5 Million to >10 Million peptides per month. Finally, to foster a market for high complexity peptide arrays, we will work out paradigmatic application examples in WP4. These aim to directly screen for antibiotic or apoptosis inducing D-peptides, and for the comprehensive readout of the different antibodies that patrol the serum of autoimmune patients. Based on user-friendly prototype machines, on first paradigmatic application examples for high complexity peptide arrays, and shielded by a strong patent, the participating SMEs will commercialise this new technology.'

Introduzione (Teaser)

If the genome seems unfathomable, imagine trying to identify minute pieces of all the products it codes for. Scientists have made this possible with a device for rapid and cost-effective identification of small parts of selected proteins.

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