PEPLASER

Combinatorial synthesis of peptide arrays with a laser printer

Coordinatore	Karlsruher Institut fuer Technologie    more  Organization address address: Kaiserstrasse 12 city: Karlsruhe postcode: 76131 contact info Nome: Natascha Cognome: Wallburg Email: send email Telefono: +49 7247 825414 Fax: +49 7247 825403
Nazionalità Coordinatore	Germany [DE]
Totale costo	4˙028˙614 €
EC contributo	2˙988˙450 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-TP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2011-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Karlsruher Institut fuer Technologie  Organization address address: Kaiserstrasse 12 city: Karlsruhe postcode: 76131 contact info Nome: Natascha Cognome: Wallburg Email: send email Telefono: +49 7247 825414 Fax: +49 7247 825403	DE (Karlsruhe)	coordinator	313˙766.70
2	AKAtech Produktions- und Handels GmbH  Organization address city: Frankenmarkt postcode: 4890 contact info Titolo: Mr. Nome: Michael Cognome: Farthofer Email: send email Telefono: +43 7684 8804 112 Fax: +43 7684 8804-9	AT (Frankenmarkt)	participant	600˙000.00
3	KMS Automation GmbH  Organization address address: Im Webertal 20 city: Schramberg-Waldmoesssingen postcode: 78713 contact info Titolo: Mr. Nome: Joachim Cognome: Schullerer Email: send email Telefono: +49 7402 9306 131 Fax: +49 7402 9306 110	DE (Schramberg-Waldmoesssingen)	participant	550˙610.00
4	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Mr. Nome: Walter Cognome: Krause Email: send email Telefono: -12052753 Fax: -12057574	DE (MUENCHEN)	participant	300˙000.00
5	UPPER AUSTRIAN RESEARCH GMBH  Organization address address: Hafenstrasse 47-51 city: Linz postcode: 4020 contact info Titolo: Dr. Nome: Alois Cognome: Sonnleitner Email: send email Telefono: +43 732 606079 24	AT (Linz)	participant	298˙800.00
6	BIOINFOBANK INSTITUTE  Organization address address: Limanowskiego 24/a 16 city: POZNAN postcode: 60744 contact info Titolo: Dr. Nome: Leszek Cognome: Rychlewski Email: send email Telefono: +48 604 628805 Fax: +48 61 8643350	PL (POZNAN)	participant	180˙000.00
7	MICROSYSTEMS LTD  Organization address address: kv. CHAIKA 15-D-21 city: Varna postcode: 9010 contact info Titolo: Mr. Nome: Nikolay Cognome: Nikolov Email: send email Telefono: +359 52 321998 Fax: +359 52 302534	BG (Varna)	participant	150˙000.00
8	TECHNICAL UNIVERSITY OF VARNA  Organization address address: Studentska 1 city: VARNA postcode: 9010 contact info Titolo: Dr. Nome: Peycho Cognome: Popov Email: send email Telefono: +359 52 383385 Fax: +359 52 302 771	BG (VARNA)	participant	150˙000.00
9	DEUTSCHES KREBSFORSCHUNGSZENTRUM  Organization address address: Im Neuenheimer Feld 280 city: HEIDELBERG postcode: 69120 contact info Titolo: Ms. Nome: Bettina Cognome: Crispin Email: send email Telefono: +49 6221-42-2700 Fax: +49 6221-42-2708	DE (HEIDELBERG)	participant	145˙233.31
10	AIMS Scientific Products GmbH  Organization address city: Braunschweig postcode: 38124 contact info Titolo: Dr. Nome: Norbert Cognome: Zander Email: send email Telefono: +49 5 31 87 60 49 40 Fax: +49 531 87 60 49 49	DE (Braunschweig)	participant	100˙080.00
11	PEPperPRINT GmbH  Organization address address: Schlossweg 9 city: Wiesloch postcode: 69168 contact info Titolo: Dr. Nome: Volker Cognome: Stadler Email: send email Telefono: +49 6202 574679 Fax: +49 6222 53301	DE (Wiesloch)	participant	100˙000.00
12	Selvita spolka z ograniczona odpowiedzialnoscia  Organization address address: ul. Gersona 2 city: KRAKOW postcode: 30818 contact info Titolo: Ms. Nome: Justyna Cognome: Supel Email: send email Telefono: +48 12 410 73 80 Fax: +48 12 410 73 82	PL (KRAKOW)	participant	99˙960.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Our particle-based method allows us to synthesise high complexity peptide arrays by combinatorial synthesis and for an unrivalled prize. We plan to further develop this new technology up to the level of robust prototype machines, and mate it to bioinformatics and readout tools. Together, our procedure(s) should boost the field of proteomics in a similar way as the lithographic technologies did with the field of genomics. Central to our novel method are the activated chemical building blocks that are “frozen” within solid amino acid particles. Thereby, we can use a colour laser printer to send them to defined addresses on a 2D support, where the particles are simply melted to induce a spatially defined coupling reaction of now freed amino acid derivatives. By repeated printing and melting cycles this simple trick yields high complexity peptide arrays. Based on existing pre-prototypes, we will develop a user-friendly peptide laser printer that spatially defined addresses our 20 different amino acid toners in high resolution to a support (WP1), and a scanner that especially fast and sensitive reads out the large formats delivered by the peptide laser printer (WP2). The increased production of amino acid toners and array supports are other bottlenecks in the output of peptide arrays that are tackled in WP3. This should allow us to increase the output of individual peptide spots from currently 0,5 Million to >10 Million peptides per month. Finally, to foster a market for high complexity peptide arrays, we will work out paradigmatic application examples in WP4. These aim to directly screen for antibiotic or apoptosis inducing D-peptides, and for the comprehensive readout of the different antibodies that patrol the serum of autoimmune patients. Based on user-friendly prototype machines, on first paradigmatic application examples for high complexity peptide arrays, and shielded by a strong patent, the participating SMEs will commercialise this new technology.'

Introduzione (Teaser)

If the genome seems unfathomable, imagine trying to identify minute pieces of all the products it codes for. Scientists have made this possible with a device for rapid and cost-effective identification of small parts of selected proteins.