MITOTARGET

Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics

 Coordinatore TROPHOS SA 

 Organization address address: PARC SCIENTIFIQUE LUMINY CASE 931
city: MARSEILLE CEDEX 9
postcode: 13288

contact info
Titolo: Mr.
Nome: Julien
Cognome: Veys
Email: send email
Telefono: 33491828283
Fax: 33491828289

 Nazionalità Coordinatore France [FR]
 Sito del progetto http://www.mitotarget.eu
 Totale costo 10˙332˙037 €
 EC contributo 5˙999˙980 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-02-01   -   2012-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TROPHOS SA

 Organization address address: PARC SCIENTIFIQUE LUMINY CASE 931
city: MARSEILLE CEDEX 9
postcode: 13288

contact info
Titolo: Mr.
Nome: Julien
Cognome: Veys
Email: send email
Telefono: 33491828283
Fax: 33491828289

FR (MARSEILLE CEDEX 9) coordinator 1˙860˙680.00
2    THE UNIVERSITY OF SHEFFIELD

 Organization address address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN

contact info
Titolo: Ms.
Nome: Gill
Cognome: Wells
Email: send email
Telefono: 441142000000
Fax: 441142000000

UK (SHEFFIELD) participant 694˙737.00
3    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Ms.
Nome: Silke
Cognome: Blohm
Email: send email
Telefono: 442078000000
Fax: 442078000000

UK (LONDON) participant 691˙983.00
4    UNIVERSITE D'AIX MARSEILLE

 Organization address address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284

contact info
Titolo: Ms.
Nome: Celine
Cognome: Damon
Email: send email
Telefono: +33 4 91 99 85 95

FR (Marseille) participant 560˙192.00
5    JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN

 Organization address address: GRUNEBURGPLATZ 1
city: FRANKFURT AM MAIN
postcode: 60323

contact info
Titolo: Dr.
Nome: Christoph
Cognome: Denecke
Email: send email
Telefono: 496980000000
Fax: 496980000000

DE (FRANKFURT AM MAIN) participant 416˙841.00
6    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Dr.
Nome: Holm
Cognome: Graessner
Email: send email
Telefono: 4970710000000
Fax: 497071000000

DE (TUEBINGEN) participant 391˙477.00
7    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Titolo: Mr.
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: 4973150000000
Fax: 4973150000000

DE (ULM) participant 194˙239.00
8    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Mr.
Nome: Christophe
Cognome: Misse
Email: send email
Telefono: 33144841770
Fax: 33144841788

FR (PARIS) participant 187˙984.00
9    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Ms.
Nome: Eveline
Cognome: Fräessdorf
Email: send email
Telefono: +49 30 450 576024
Fax: +49 30 450 576954

DE (BERLIN) participant 174˙376.00
10    MEDIZINISCHE HOCHSCHULE HANNOVER

 Organization address address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625

contact info
Titolo: Ms.
Nome: Cornelia
Cognome: Gausmann
Email: send email
Telefono: 495115000000
Fax: 495115000000

DE (HANNOVER) participant 163˙455.00
11    Centre hospitalier universitaire de Limoges

 Organization address address: avenue Martin-Luther-King 2
city: Limoges
postcode: 87000

contact info
Titolo: Mr.
Nome: Jean-Louis
Cognome: Calise
Email: send email
Telefono: +33 5 55 05 80 53
Fax: +33 5 55 05 66 96

FR (Limoges) participant 144˙877.00
12    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Maria
Cognome: Vereeken
Email: send email
Telefono: +32 16 326504
Fax: +32 16 326515

BE (LEUVEN) participant 142˙031.00
13    HOSPICES CIVILS DE LYON

 Organization address address: 3 Quai des Celestins
city: LYON
postcode: 69229

contact info
Titolo: Ms.
Nome: Cécile
Cognome: Legros
Email: send email
Telefono: 33472115422
Fax: 33472115190

FR (LYON) participant 98˙258.00
14    CHU DE NICE

 Organization address address: AVENUE VICTORIA 4
city: NICE
postcode: 6003

contact info
Titolo: Mr.
Nome: Loic
Cognome: Mondoloni
Email: send email
Telefono: 33492034011
Fax: 33492034075

FR (NICE) participant 84˙193.00
15    CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE

 Organization address address: AVENUE OSCAR LAMBRET 2
city: LILLE
postcode: 59037

contact info
Titolo: Ms.
Nome: Francine
Cognome: Niset
Email: send email
Telefono: +33 3 20 43 23 13
Fax: +33 3 20 44 62 43

FR (LILLE) participant 73˙201.00
16    CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER

 Organization address address: Avenue du Doyen Gaston Giraud 191
city: MONTPELLIER
postcode: 34295

contact info
Titolo: Ms.
Nome: Valérie
Cognome: Thorin
Email: send email
Telefono: +33 4 67 33 96 43
Fax: +33 4 67 33 03 36

FR (MONTPELLIER) participant 68˙381.00
17    MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

 Organization address address: UNIVERSITAETSPLATZ 10
city: HALLE (Saale)
postcode: 6099

contact info
Titolo: Dr.
Nome: Sigrid
Cognome: Köhne
Email: send email
Telefono: 493456000000
Fax: 493456000000

DE (HALLE (Saale)) participant 53˙075.00
18    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Mr.
Nome: Molenaar
Cognome: Pierre
Email: send email
Telefono: none
Fax: none

NL (UTRECHT) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

als    diseases    therapeutic    alzheimer    mitochondrial    sme    mitotarget    class    clinical    neurodegenerative    mechanisms    dysfunction    linking    disease   

 Obiettivo del progetto (Objective)

'Mitochondrial dysfunction is a major hallmark of various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases or Amyotrophic Lateral Sclerosis (ALS). However linking mitochondrial dysfunction to the pathogenesis of some of these diseases still needs to be elucidated. Furthermore, in pathologies where this link is already established, the question remains whether specific targets or mechanisms involved in mitochondrial dysfunction will be amenable to therapeutic intervention. MitoTarget is an ambitious project aimed at providing solid data to better understand and exploit the circumstantial evidence linking mitochondrial dysfunction with neuronal dysfunction culminating in neurodegenerative disease. A 36 months translational research program will bring together a unique partnership between basic scientists, a seasoned team of clinical investigators and a SME that has identified a first-in-class compound, TRO19622, that targets mitochondria and has powerful neuroprotective and neuroregenerative activities. In parallel, and orchestrated by the SME that is the coordinator of the project, MitoTarget will bring together a more comprehensive insight into the mechanisms leading to mitochondrial impairments and establish their clinical relevance in a severe orphan neurodegenerative disease, ALS. If successful, it is expected that from this proof of principle a new class of therapeutic agents targeting the underlying mitochondrial dysfunction in neurons or their supporting cells will emerge. Results of the project have the potential to create a new paradigm for the drug discovery for neurodegenerative diseases.'

Introduzione (Teaser)

An EU project is investigating how proper mitochondrial functioning is vital for warding off neurodegeneration and brain diseases such as Alzheimer's.

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