NANOMMUNE

Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system

 Coordinatore KAROLINSKA INSTITUTET 

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Per-Olof
Cognome: Larsson
Email: send email
Telefono: +46 8 524 875 00
Fax: +46 8 33 69 81

 Nazionalità Coordinatore Sweden [SE]
 Sito del progetto http://www.nanommune.eu
 Totale costo 4˙310˙500 €
 EC contributo 3˙358˙500 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2007-SMALL-1
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-09-01   -   2011-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Per-Olof
Cognome: Larsson
Email: send email
Telefono: +46 8 524 875 00
Fax: +46 8 33 69 81

SE (STOCKHOLM) coordinator 0.00
2    EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT

 Organization address address: Ueberlandstrasse 129
city: DUEBENDORF
postcode: 8600

contact info
Titolo: Ms.
Nome: Heidi
Cognome: Leutwyler
Email: send email
Telefono: +41 44 823 4591
Fax: +41 44 823 4016

CH (DUEBENDORF) participant 0.00
3    INSTITUTE OF OCCUPATIONAL MEDICINE

 Organization address address: Research Avenue North, Riccarton 45
city: EDINBURGH
postcode: EH14 4AP

contact info
Titolo: Ms.
Nome: Susan
Cognome: Scarisbrick
Email: send email
Telefono: +44 131 449 8065
Fax: +44 870 850 5132

UK (EDINBURGH) participant 0.00
4    KUNGLIGA TEKNISKA HOEGSKOLAN

 Organization address address: Valhallavaegen 79
city: STOCKHOLM
postcode: 10044

contact info
Titolo: Mr.
Nome: Alf Thomas
Cognome: Sjöland
Email: send email
Telefono: +46 8 790 4113
Fax: +46 8 751 1793

SE (STOCKHOLM) participant 0.00
5    NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

 Organization address address: WILLOWDALE ROAD MS L 2015
city: MORGANTOWN
postcode: 26505

contact info
Titolo: Dr.
Nome: Anna
Cognome: Shvedova
Email: send email
Telefono: + 1 304 285 6177
Fax: + 1 304 285 5938

US (MORGANTOWN) participant 0.00
6    North Carolina State University

 Organization address address: SULLIVAN DRIVE 270
city: RALEIGH
postcode: 27695 7514

contact info
Titolo: Dr.
Nome: Matthew
Cognome: Ronning
Email: send email
Telefono: + 1 919 515 2444
Fax: + 1 919 515 7721

US (RALEIGH) participant 0.00
7    TURUN YLIOPISTO

 Organization address address: YLIOPISTONMAKI
city: TURUN YLIOPISTO
postcode: 20014

contact info
Titolo: Dr.
Nome: Eliisa
Cognome: Särkilahti
Email: send email
Telefono: +358 2 333 6155
Fax: +358 2 333 6446

FI (TURUN YLIOPISTO) participant 0.00
8    UNIVERSITAET ZU KOELN

 Organization address address: ALBERTUS MAGNUS PLATZ
city: KOELN
postcode: 50923

contact info
Titolo: Ms.
Nome: Wilfried
Cognome: Hundt
Email: send email
Telefono: +49 221 470 3744
Fax: +49 221 470 5279

DE (KOELN) participant 0.00
9    UNIVERSITY OF PITTSBURGH

 Organization address address: WESLEY W POSVAR HALL 4E
city: PITTSBURGH
postcode: 15260

contact info
Titolo: Mr.
Nome: Matthew
Cognome: Weaver
Email: send email
Telefono: + 1 412 383 6900
Fax: + 1 412 383 7658

US (PITTSBURGH) participant 0.00
10    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Ms.
Nome: Eva
Cognome: Lind
Email: send email
Telefono: +46 18 471 3024
Fax: +46 18 471 3001

SE (UPPSALA) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

human    institutes    read    profiles    hazards    cells    competent    toxic    gaps    review    characterisation    categories    engineered    procurement    hazardous    regarding    immune    environment    nanotubes    vitro    promise    determine    recognition    multidisciplinary    nanotoxic    nanommune    adverse    materials    assessments    macrophages    ens    health    nanomaterials    synthesis    pathogens    foreign    designed   

 Obiettivo del progetto (Objective)

'Engineered nanomaterials (ENs) present tremendous opportunities for industrial growth and development, and hold great promise for the enrichment of the lives of citizens, in medicine, electronics, and numerous other areas. However, there are considerable gaps in our knowledge concerning the potential hazardous effects of ENs on human health and the environment. Our EU-US partnership is committed to filling these knowledge gaps through a comprehensive assessment of ENs, with particular focus on effects on the immune system. The immune system is designed to respond to pathogens and foreign particles, and a core concept underpinning the current project is that the recognition versus non-recognition of ENs by immune-competent cells will determine the distribution as well as the toxicological potential of these materials. Our multidisciplinary consortium will focus on the procurement, synthesis and detailed physico-chemical characterization of representative categories of ENs, and the monitoring of potential hazardous effects using an array of in vitro and in vivo systems, as well as transcriptomic and oxidative lipidomic testing to determine specific nanotoxic profiles (signatures) of these materials. The final and integrative component of our research project is risk assessment of potential adverse effects of ENs on human health, and the dissemination of our findings. Through our comprehensive approach, which combines analytical procedures from many different disciplines and leading experts from several national institutes devoted to occupational and environmental safety, we aim to establish a panel of read-out systems for the prediction of the toxic potential of existing and emerging ENs, thus enabling a continuous and sustainable growth of the nanotechnologies. Overall, the results generated through this international program will contribute to the understanding and mitigation of possible adverse effects of nanomaterials.'

Introduzione (Teaser)

Engineered nanomaterials have the potential to improve many aspects of modern day living. However, more knowledge is needed regarding potential hazards to human health.

Descrizione progetto (Article)

The 'Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system' (Nanommune) project is assessing the potential of engineered nanomaterials (ENs) to adversely affect the human immune system. The 3-year project brings together 10 partner institutes in the EU and the United States focusing on procurement, synthesis and detailed physicochemical characterisation of various EN categories.

The immune system is designed to respond to threats in the form of pathogens or foreign agents. With this in mind, Nanommune is working to show that recognition or non-recognition of ENs by immune-competent cells is a determining factor in their distribution and harmful effects.

A multidisciplinary approach is in place to monitor these potential hazards and determine nanotoxic profiles of ENs. The end goal is to create a base of read-out systems for predicting the toxic potential of ENs.

To date, a management office has been set up and a project website launched. Kick-off and consortium meetings have also been held. Various articles have been published, including one review in the Annual Review of Pharmacology and Toxicology.

In the first 18 months, and after establishing various standard operating procedures (SOPs), activities concentrated on material synthesis and characterisation and in vitro assessments of ENs. So far, researchers have studied the nanomaterials of 15 systems, allowing partner institutions to make good progress in enhancing knowledge of how macrophages can be alerted to or recognise nanomaterials. Macrophages act as sensors that detect a threat and initiate a relevant immune response such as inflammation or elimination.

Results from one set of studies show promise for having carbon nanotubes actually degrade in the biological environment. The scientists also showed that nanotubes are recognisable by macrophages. Other studies have made headway regarding the development of materials for drug delivery and other biomedical applications.

The Nanommune project's goal of elucidating the hazardous effects of ENs on the immune system will ultimately deliver reliable and sound assessments of the risks to human health that these materials pose. Results are set to benefit public health, researchers and industry.

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