RIBOGENES

The role of noncoding RNA in sense and antisense or orientation in epigenetic control of rRNA genes

 Coordinatore DEUTSCHES KREBSFORSCHUNGSZENTRUM 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 831˙756 €
 EC contributo 831˙756 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2008-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-03-01   -   2014-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Ina
Cognome: Krischek
Email: send email
Telefono: +49 6221 42 2700
Fax: +49 6221 42 2708

DE (HEIDELBERG) hostInstitution 831˙756.00
2    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Prof.
Nome: Ingrid
Cognome: Grummt
Email: send email
Telefono: ++49 6221 42 3423
Fax: ++49 6221 42 3467

DE (HEIDELBERG) hostInstitution 831˙756.00

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modifications    rdna    igs    transcriptional    regulation    chromatin    silencing    ncrnas    antisense    expression    structure    intergenic    genes    norc    epigenetic    gene    rrna    directed    transcripts    rnas    fraction    rna   

 Obiettivo del progetto (Objective)

'Non-coding RNAs (ncRNAs) play a significant role in the control of gene expression and epigenetic regulation. It seems that ncRNAs might be numerous and highly adapted in roles that require specific nucleic acid recognition without complex catalysis, such as in guiding RNA modifications or in directing post-transcriptional regulation of gene expression and chromatin structure. Our previous work has revealed that NoRC, a chromatin remodeling complex that triggers heterochromatin formation and transcriptional silencing of a fraction of rRNA genes, is associated with 100-250 nt RNAs that originate from the intergenic spacer (IGS) separating rDNA repeats. Furthermore, a fraction of rDNA is transcribed in antisense orientation. Both IGS RNA and antisense transcripts display a growth- and tissue-specific expression pattern. The goal of this project is to decipher the role of NoRC-associated RNA in alterations of chromatin structure and epigenetic control of rDNA. Our research will focus on the synthesis, regulation, and processing of intergenic and antisense transcripts in response to cell growth and differentiation as well as on the role of NoRC-associated RNA in epigenetic regulation of rRNA genes. The following points will be addressed: (1) Deciphering the mechanism underlying RNA-directed establishment of specific epigenetic marks and formation of silent chromatin domains, (2) Functional analysis of posttranscriptional modifications that regulate RNA binding and NoRC activity, (3) Identification of non-ribosomal target genes of NoRC, and (4) Elucidation of the link between transcriptional activity and active demethylation of the rDNA promoter. Given the fact that basic regulatory principles are conserved throughout evolution, this work will have a great impact on our understanding of RNA-directed silencing mechanisms and will reveal how epigenetic defects cause human diseases.'

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