TCMCANCER

Traditional Chinese Medicine in the Post-genomic era: identifying lead therapeutic compounds against cancer

 Coordinatore Luxembourg Institute of Health 

 Organization address address: Val Fleuri 84
city: LUXEMBOURG
postcode: 1526

contact info
Titolo: Mr.
Nome: Daniel
Cognome: Cardao
Email: send email
Telefono: +352-26 970 1
Fax: +352-26970 719

 Nazionalità Coordinatore Luxembourg [LU]
 Totale costo 237˙600 €
 EC contributo 237˙600 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-IRSES-2008
 Funding Scheme MC-IRSES
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-03-01   -   2013-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Luxembourg Institute of Health

 Organization address address: Val Fleuri 84
city: LUXEMBOURG
postcode: 1526

contact info
Titolo: Mr.
Nome: Daniel
Cognome: Cardao
Email: send email
Telefono: +352-26 970 1
Fax: +352-26970 719

LU (LUXEMBOURG) coordinator 237˙600.00

Mappa

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tcm    action    medicine    appropriate    therapeutic    models    efficacy    compounds    cancer   

 Obiettivo del progetto (Objective)

'This application aims at identifying and characterizing a set of lead therapeutic compounds against cancer (breast, lung and brain), based on current knowledge from Traditional Chinese Medicine (TCM). TCM has a very long tradition in the prevention and treatment of a variety of diseases yet, in contrast to target-oriented Western medicine, TCM uses a holistic and synergistic approach, which can be very effective for complex medical problems. However, the exact composition of the compounds that exert the therapeutic effect is not known. As there is little understanding about the mechanisms of action of many TCM therapies, modern and multidisciplinary Biotech research (functional genomics/ systems biology) should be applied on appropriate and highly defined cancer models. The presented project will focus on the isolation and characterization of chemical compounds from TCM that show anti-tumoral efficacy. From a library of therapeutic compounds available, a set of lead therapeutic substances will be identified using high throughput screening technologies in appropriate preclinical cancer models. Moreover, their mechanism of action will be further studied using genome wide analyses. Finally, their therapeutic efficacy will be tested in appropriate animal models.'

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