FLAVIOLA

Targeted delivery of dietary flavanols for optimal human cell function: Effect on cardiovascular health

 Coordinatore HEINRICH-HEINE-UNIVERSITAET DUESSELDORF 

 Organization address address: UNIVERSITAETSSTRASSE 1
city: DUSSELDORF
postcode: 40225

contact info
Titolo: Ms.
Nome: Doris
Cognome: Neubert
Email: send email
Telefono: +49 211 8119586
Fax: +49 211 8118576

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.flaviola.org/
 Totale costo 3˙989˙169 €
 EC contributo 2˙999˙195 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2008-2B
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-09-01   -   2013-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

 Organization address address: UNIVERSITAETSSTRASSE 1
city: DUSSELDORF
postcode: 40225

contact info
Titolo: Ms.
Nome: Doris
Cognome: Neubert
Email: send email
Telefono: +49 211 8119586
Fax: +49 211 8118576

DE (DUSSELDORF) coordinator 600˙800.00
2    THE UNIVERSITY OF READING

 Organization address address: WHITEKNIGHTS CAMPUS WHITEKNIGHTS HOUSE
city: READING
postcode: RG6 6AH

contact info
Titolo: Ms.
Nome: Sarah
Cognome: Page
Email: send email
Telefono: +44 11837888321
Fax: +44 118378 8979

UK (READING) participant 589˙410.00
3    UNIVERSITEIT MAASTRICHT

 Organization address address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD

contact info
Titolo: Dr.
Nome: Joseph Ih
Cognome: Janssen
Email: send email
Telefono: +31 433881961
Fax: +31 433670286

NL (MAASTRICHT) participant 450˙012.00
4    Mars Belgium

 Organization address address: Kleine Kloosterstraat 8
city: SINT STEVENS WOLUWE
postcode: 1932

contact info
Titolo: Ms.
Nome: Ellen
Cognome: Verhoeven
Email: send email
Telefono: +31 413 383308
Fax: +31 413 383308

BE (SINT STEVENS WOLUWE) participant 311˙460.00
5    UNIVERSITEIT GENT

 Organization address address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000

contact info
Titolo: Ms.
Nome: Nathalie
Cognome: Vandepitte
Email: send email
Telefono: +32 9 264 3029
Fax: +32 9 264 3583

BE (GENT) participant 300˙591.00
6    INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

 Organization address address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338

contact info
Titolo: Mr.
Nome: Charles
Cognome: Mathiaux
Email: send email
Telefono: +33 4 73 62 44 33
Fax: +33 4 73 62 44 51

FR (PARIS CEDEX 07) participant 299˙842.00
7    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Prof.
Nome: Jon
Cognome: Lundberg
Email: send email
Telefono: 46852487952
Fax: 468332278

SE (STOCKHOLM) participant 299˙840.00
8    SCIPROM SARL

 Organization address address: RUE DU CENTRE 70
city: Saint-Sulpice
postcode: 1025

contact info
Titolo: Dr.
Nome: Kirsten
Cognome: Leufgen
Email: send email
Telefono: +41 21 694 04 10

CH (Saint-Sulpice) participant 147˙240.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

nutritionally    food    flavanol    cf    significant    plant    human    benefits    data    mortality    outcomes    innovative    nutrition    morbidity    function    diets    regard    epidemiological    prototypes    cellular    cardiovascular    matrices    blood    intake    healthy    thereby    foods    humans    nutrient    absorption    cocoa    adme    containing    pressure    flaviola    risk    population    mediated    analytical    pas    health    dietary    evidence    responsible    vascular    flavanols    intervention    fruit    clinical   

 Obiettivo del progetto (Objective)

'Nutrition, i.e. our daily diet, is a major life style factor, greatly impacting on human health and disease. Epidemiological evidence suggests that diets rich in plant-based foods and beverages decrease the risk for cardiovascular morbidity and mortality. Various phytochemical constituents, in particular a class of compounds called flavanols, have been avidly investigated in recent years. Current dietary interventions in humans using flavanol-containing foods have substantiated epidemiological data indicating various potential dietary flavanol-mediated bioactivities, including improved vascular function, decreased blood pressure, attenuated platelet clotting, and improved immune responses. Latest innovations in flavanol analytics, chemistry, food processing technology, and cardiovascular function analysis make the elucidation of underlying mechanisms of flavanol bioactivity not just possible, but also impactful with regard to dietary advice and public health. Thus, a practical application of novel findings emanating from flavanol research in terms of a science/evidence-based development represents a worthwhile endeavour. This entails development of novel food ingredients, and innovative nutrient-delivery matrices. Such novel, nutritionally responsible food formulations hold the potential to open novel avenues in the prevention and amelioration of cardiovascular diseases in Europe. FLAVIOLA aims at: (i) illuminating the cellular and sub-cellular effects of flavanols and their main human metabolites; (ii) investigating key parameters of dietary flavanol absorption, clearance and efficacy towards surrogate markers of cardiovascular function in humans; (iii) developing innovative, functional, and nutritionally responsible food matrices for optimised dietary flavanol delivery; and finally (iv) demonstrating cardiovascular benefits and safety for a newly developed prototype food product.'

Introduzione (Teaser)

Good lifestyle and nutrition are vital to promoting health. Outcomes of initial clinical dietary intervention studies have indicated that plant-based diets, rich in flavanols, effectively reduce the risk for cardiovascular morbidity and mortality.

Descrizione progetto (Article)

The EU-funded http://www.flaviola.org/ (FLAVIOLA) project investigated the impact of flavanol consumption in the EU and developed cocoa flavanol (CF)-rich food product prototypes. Comprehensive studies were carried out to assess dietary sources and average habitual intake of flavanols, such as epicatechin and catechin, and of their oligomeric derivatives, the proanthocyanidins (PAs) in Europe. This work was based on utilizing the FLAVIOLA Food Composition Database (developed by project members), and revealed that tea, pome fruit (apples, pears etc.), berries, cocoa products and stone fruit are major contributors to the total dietary intake amount of flavanols in the EU.

Moreover, researchers addressed previously existing gaps in our knowledge with regard to flavanols, FLAVIOLA developed and validated innovative analytical methods to assess the absorption, distribution, metabolism and excretion (ADME) of flavanols following dietary intake, and to study their biomedical effects in rigorous clinical dietary intervention studies and population-based epidemiological investigations.

For the first time, a method for the analysis of CFs and PAs in food products received an accreditation by the Association of Analytical Communities (AOAC). Another significant milestone of FLAVIOLA was the development for use in the clinical studies of standardized CF-containing food product prototypes along with adequate flavanol-free controls that are matched to CF-containing test products with regard to macro-, micro-nutrient content, caloric density, and orosensory properties, thus providing a fully valid placebo control.

Study outcomes comprehensively demonstrate CF-mediated cardiovascular health benefits in healthy men and women. CF intake significantly improved parameters of cardiovascular function including arterial flow-mediated dilation and blood pressure. In the elderly, CF-rich diets helped to reverse age-related increases in blood pressure and vascular stiffness, thereby improving blood circulation. No significant intra- and inter-individual variability in flavanol ADME was found across study populations, thus corroborating the tenability for developing population-based CF intake guidelines.

The outcomes of FLAVIOLA have provided novel and innovative data and furthered our knowledge about dietary flavanols and their beneficial effects on cardiovascular health. Project outcomes have thereby laid solid foundations for future research into innovative therapeutic- and dietary strategies to improve cardiovascular health and to support healthy aging.

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