Persistence of allergic sensitization


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 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙727˙981 €
 EC contributo 1˙727˙981 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-StG
 Funding Scheme ERC-SG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-12-01   -   2014-11-30


# participant  country  role  EC contrib. [€] 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
postcode: 80539

contact info
Titolo: Mr.
Nome: Mathias
Cognome: Becker
Email: send email
Telefono: 498922000000
Fax: 498922000000

DE (MUENCHEN) beneficiary 94˙054.34

 Organization address address: Maximiliansplatz 2
postcode: 91054

contact info
Titolo: Dr.
Nome: Katrin
Cognome: Faber
Email: send email
Telefono: 4991320000000
Fax: 4991320000000

DE (ERLANGEN) hostInstitution 1˙633˙926.80

 Organization address address: Maximiliansplatz 2
postcode: 91054

contact info
Titolo: Prof.
Nome: David
Cognome: Voehringer
Email: send email
Telefono: +49 9131 85 32735
Fax: +49 9131 85 32733

DE (ERLANGEN) hostInstitution 1˙633˙926.80


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

vivo    plasma    mouse    reporter    mast    us    ige    molecules    determine    basophils    cells    allergen    turnover    producing    mice   

 Obiettivo del progetto (Objective)

'Allergic disorders are dramatically increasing in the western world over the past several years. Allergies are inappropriate immune responses directed against harmless environmental antigens. Upon primary allergen encounter B cells are induced to differentiate into IgE producing plasma cells. Mast cells and basophils are then sensitized by binding of allergen-specific IgE molecules to the high-affinity IgE receptor on the cell surface. A second allergen exposure causes cross-linking of IgE molecules on mast cells and basophils which results in degranulation of pro-inflammatory mediators. Allergen-specific IgE can be detected many months after the sensitization phase despite the fact that IgE has a very short half-life. This suggests that small amounts of allergen-specific IgE are constantly secreted by long-lived IgE producing plasma cells. The development, turnover and fate of IgE producing cells in vivo are largely unknown. Therefore, we propose to study these important issues by using genetically modified mouse strains and cutting edge technology. We will use IgE-FLAG-GFP reporter mice to trace IgE-producing cells in vivo by fluorescence microscopy and 2-photon live imaging. The reporter mice will allow us to isolate IgE-producing cells so that we can determine their gene expression profile. Furthermore, we will determine the turnover and lifespan of IgE producing cells in vivo by BrdU incorporation. Finally, we will generate an IgE-Cre knock-in mouse to specifically delete conditional alleles in IgE-producing cells. Taken together, these important experiments will help us to better understand the biology of IgE-producing cells and may result in development of novel therapeutic strategies.'

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