CHEMSCREEN

CHEMICAL SUBSTANCE IN VITRO/IN SILICO SCREENING SYSTEM TO PREDICT HUMAN- AND ECOTOXICOLOGICAL EFFECTS

 Coordinatore BioDetection Systems B.V. 

 Organization address address: Science Park 406
city: Amsterdam
postcode: 1098 XH

contact info
Titolo: Ms.
Nome: Yvette
Cognome: Van Scheppingen
Email: send email
Telefono: +31 20 4350750
Fax: +31 20 4350757

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 4˙609˙052 €
 EC contributo 3˙496˙723 €
 Programma FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change)
 Code Call FP7-ENV-2009-1
 Funding Scheme CP-FP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-01-01   -   2013-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BioDetection Systems B.V.

 Organization address address: Science Park 406
city: Amsterdam
postcode: 1098 XH

contact info
Titolo: Ms.
Nome: Yvette
Cognome: Van Scheppingen
Email: send email
Telefono: +31 20 4350750
Fax: +31 20 4350757

NL (Amsterdam) coordinator 995˙904.00
2    NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

 Organization address address: Schoemakerstraat 97
city: DEN HAAG
postcode: 2600 JA

contact info
Titolo: Dr.
Nome: Dinant
Cognome: Kroese
Email: send email
Telefono: +31 30 69444049
Fax: +31 30 6944989

NL (DEN HAAG) participant 400˙936.00
3    RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN

 Organization address address: Antonie Van Leeuwenhoeklaan 9
city: BILTHOVEN
postcode: 3721 MA

contact info
Titolo: Prof.
Nome: Aldert
Cognome: Piersma
Email: send email
Telefono: +31 30 274 2526
Fax: +31 30 274 4446

NL (BILTHOVEN) participant 385˙951.00
4    DANMARKS TEKNISKE UNIVERSITET

 Organization address address: Anker Engelundsvej 1, Building 101A
city: KONGENS LYNGBY
postcode: 2800

contact info
Titolo: Ms.
Nome: Eva Bay
Cognome: Wedebye
Email: send email
Telefono: +45 35 88 76 04
Fax: +45 72 34 70 01

DK (KONGENS LYNGBY) participant 352˙975.00
5    UNIVERSITAT KONSTANZ

 Organization address address: UNIVERSITATSSTRASSE 10
city: KONSTANZ
postcode: 78457

contact info
Titolo: Ms.
Nome: Gertraud
Cognome: Plaza Pascual
Email: send email
Telefono: 497532000000
Fax: 497532000000

DE (KONSTANZ) participant 299˙600.00
6    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Prof.
Nome: Michael
Cognome: Schwarz
Email: send email
Telefono: +49 7071 2977398
Fax: +49 7071 292273

DE (TUEBINGEN) participant 293˙680.00
7    PROCTER & GAMBLE SERVICES COMPANY NV

 Organization address address: TEMSELAAN 100
city: STROMBEEK BEVER
postcode: 1853

contact info
Titolo: Ms.
Nome: Kate
Cognome: Waters
Email: send email
Telefono: +44 191 2281805
Fax: +44 17842 72543

BE (STROMBEEK BEVER) participant 286˙675.00
8    FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V

 Organization address address: Hansastrasse 27C
city: MUENCHEN
postcode: 80686

contact info
Titolo: Ms.
Nome: Andrea
Cognome: Zeumann
Email: send email
Telefono: +49 89 1205 2723
Fax: +49 89 1205 77 2723

DE (MUENCHEN) participant 266˙346.00
9    SIMPPLE S.L.

 Organization address city: Tarragona
postcode: 43007

contact info
Titolo: Ms.
Nome: Eva
Cognome: Vilà Méndez
Email: send email
Telefono: +34 977 110520
Fax: +34 977 110529

ES (Tarragona) participant 214˙656.00
10    PROCTER & GAMBLE EUROCOR N.V.

 Organization address address: Temselaan 100
city: STROMBEEK-BEVER
postcode: 1853

contact info
Titolo: Ms.
Nome: Kate
Cognome: Waters
Email: send email
Telefono: +44 191 2281805
Fax: +44 17842 72543

BE (STROMBEEK-BEVER) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

silico    throughput    classify    rapid    fill    alternative    chemical    reproductive    chemicals    gap    chemscreen    toxic    toxins    endocrine    tests    vivo    with    toxicity    scientists    identifies    vitro    consuming    assay    tool    accuracy    generate    safety    time    computer    simple    decision    toxicological    schedule    screening    data    animal   

 Obiettivo del progetto (Objective)

'The current system of risk assessment of chemicals is complex, very resource-intensive and extremely time-consuming. Because of this, there is a great need to modernize this process. However, this is not feasible without alternative, integrated testing strategies in which chemical characteristics are used to more advantage and where costly and time consuming animal tests are replaced to a large extent by more rapid, cheap and ethically less controversial methods. This is particularly needed for reproductive toxicity testing of chemicals. Reproductive toxicity is important to assess both human and environmental toxicity and uses the most animals in toxicity testing. Unfortunately, there are very few alternative methods. ChemScreen aims to fill this gap and place the tests in a more general innovative animal-free testing strategy. For this, we will generate a simple rapid screening system, which aims at widespread implementation within the tight time schedule of the REACH program. It will be a flexible tool that can be adapted and used for applications beyond the scope of REACH and in the post-REACH period. It will use in silico methods for prescreening chemicals for all relevant toxic effects. When found positive, this will be followed by further in silico and in vitro tests, most of which are available already. To fill the gap of suitable alternative methods for reproductive toxicity testing we will use a novel high throughput approach combining in silico/in vitro methods. In this approach we will combine knowledge of critical processes affected by reproductive toxicants with knowledge on the mechanistic basis of such effects. Straightforward data interpretation and decision trees will be developed in which all information on the potential toxicity of a chemical is considered. In this way we will provide a cost-effective means to generate a basic set of data on toxicological properties of chemicals and a decision tool to assess if further testing of chemicals is required.'

Introduzione (Teaser)

The current system for assessing the risks of chemicals is very complicated, time consuming and heavily reliant on in vivo testing. EU funding enabled the development of rapid, computer-based high-throughput screening for major impact.

Descrizione progetto (Article)

Many industrial chemicals in common use have not undergone toxicological testing or been classified regarding safety. In response to the pressing need to develop alternative testing methodologies to rapidly classify current and future chemicals, the EU-funded project http://www.chemscreen.eu/ (CHEMSCREEN) was launched by nine partners from five European countries.

With a focus on non-animal based reproductive toxins, the team produced a simple and rapid in silico (computer-based) screening tool to meet the time schedule of the European Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Exploiting the power of computing enables a rapid preliminary screening of molecular and chemical structures in new formulations that are compared to known toxins. According to the types of likely toxic effects, genotoxic or carcinogenic for example, subsequent in silico and in vitro testing are used to further classify the materials.

CHEMSCREEN developed a high-throughput screening assay for reproductive toxicity that identifies increasingly present endocrine active compounds, also known as endocrine disruptors, with 100% accuracy. The assay also identifies chemicals causing deformities in reproductive organs with 87% accuracy. The testing platform enables identification of potential reproductive and developmental toxins prior to in vivo testing for more effective and efficient (reduced) use of animal testing. Scientists have also developed methods to integrate chemical test data from in silico and in vitro analyses with reference data using a variety of databases.

With continued promotion of the in silico tools and test batteries to regulatory agencies to facilitate widespread acceptance, CHEMSCREEN scientists are on the road to achieving significant reductions in animal testing and testing costs. Rapid toxicological testing will get all chemicals in use properly evaluated and facilitate rapid classification of all new chemicals as well for the safety and well-being of EU citizens and the environment.

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