ARIADNE

Signaling circuitry controlling fungal virulence: identification and characterization of conserved and specific fungal virulence genes as common antifungal targets

Coordinatore	CARLSBERG AS    more  Organization address address: NY CARLSBERG VEJ 100 city: KOBENHAVN postcode: 1799 contact info Titolo: Prof. Nome: Juergen Cognome: Wendland Email: send email Telefono: +45 3327 5230 Fax: +45 3327 4708
Nazionalità Coordinatore	Denmark [DK]
Totale costo	2˙908˙908 €
EC contributo	2˙908˙908 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ITN-2008
Funding Scheme	MC-ITN
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2014-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CARLSBERG AS  Organization address address: NY CARLSBERG VEJ 100 city: KOBENHAVN postcode: 1799 contact info Titolo: Prof. Nome: Juergen Cognome: Wendland Email: send email Telefono: +45 3327 5230 Fax: +45 3327 4708	DK (KOBENHAVN)	coordinator	678˙224.00
2	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN  Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX contact info Titolo: Dr. Nome: Helena Cognome: Rogers Email: send email Telefono: +44 1224 273682 Fax: +44 1224 272319	UK (ABERDEEN)	participant	413˙704.00
3	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: Regine Cognome: Kahmann Email: send email Telefono: 496421000000 Fax: 496421000000	DE (MUENCHEN)	participant	392˙208.00
4	UNIVERSIDAD DE CORDOBA  Organization address address: AVENIDA DE MEDINA AZAHARA 5 city: CORDOBA postcode: 14005 contact info Titolo: Prof. Nome: Antonio Cognome: Di Pietro Email: send email Telefono: +34 957 218981 Fax: +34 957 212072	ES (CORDOBA)	participant	391˙620.00
5	THE UNIVERSITY OF EXETER  Organization address address: Northcote House, The Queen's Drive city: EXETER postcode: EX4 4QJ contact info Titolo: Dr. Nome: Enda Cognome: Clarke Email: send email Telefono: 441392000000 Fax: 441392000000	UK (EXETER)	participant	226˙388.00
6	LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS KNOELL INSTITUTE  Organization address address: Beutenbergstrasse 11a city: JENA postcode: 7745 contact info Titolo: Dr. Nome: Michael Cognome: Ramm Email: send email Telefono: +49 3641 532 1011 Fax: +49 3641 532 0801	DE (JENA)	participant	214˙531.00
7	BAYER CROPSCIENCE SA  Organization address address: RUE JEAN MARIE LECLAIR 16 city: LYON postcode: 69009 contact info Titolo: Dr. Nome: Eva Cognome: Franken Email: send email Telefono: +33 4 72 85 23 43 Fax: +33 672829983	FR (LYON)	participant	201˙552.00
8	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Ms. Nome: Marie-Claude Cognome: Paulien Email: send email Telefono: +331 30 83 34 57 Fax: +33 01 30 83 34 58	FR (PARIS CEDEX 07)	participant	201˙552.00
9	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Carlos Manuel Cognome: Abad Ruiz Email: send email Telefono: +34 915668852 Fax: +34 915668913	ES (MADRID)	participant	189˙129.00

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 Obiettivo del progetto (Objective)

'Fungi are heterotrophic microorganisms with devastating impact on agriculture and human health. Agricultural production worth billions of € is destroyed annually by fungal diseases. Human fungal infections have severe consequences on the growing number of immuno-compromised patients, with high mortality rates associated with Aspergillus and Candida infections. There is a critical need to further the development of new antifungals, which requires a comprehensive molecular knowledge on fungal pathogenesis and signal transduction. ARIADNE uses a comparative biological approach at the systems biology level to identify and validate signalling target genes that play an essential causative role in fungal virulence on both plant and human hosts. To establish a comprehensive view of fungal pathogenesis seven pathogenic species will be studied, including the two major fungal pathogens of humans Aspergillus fumigatus and Candida albicans, the devastating plant pathogens Fusarium oxysporum, Magnaporthe grisea and Mycospherella graminicola, as well as two established model pathogens of filamentous and dimorphic fungi, Ashbya gossypii and Ustilago maydis. This array of fungal species cuts across diverse taxonomic groups, covering several hundred million years of evolution. The central scientific and technological challenges for ARIADNE are to 1) integrate parallel transcriptomics, proteomics, and chemical genetics for a comprehensive set of major fungal pathogens, 2) identify evolutionarily conserved and species specific signalling effectors which act as key players in fungal virulence, 3) validate these proteins as candidate targets for small molecule inhibitors. This groundbreaking scientific and teaching approach will open up new avenues on how to look at fungal pathogenicity and will generate an unprecedented knowledge platform, which will facilitate the discovery and validation of antifungal targets in both the agricultural and the pharmaceutical sectors.'

Introduzione (Teaser)

European researchers have formulated a new integrated approach to the devastating effects of fungal diseases. Molecular knowledge of virulence mechanisms combined with training of scientists in a cross-sectorial environment has yielded significant results in the fight against fungal infection.