MODOPCFATE
Modulation of oligodendrocyte precursor cells differentiation fate during CNS remyelination
| Coordinatore | INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Organization address
address: UL. LUDWIKA PASTEURA 3 contact info |
| Nazionalità Coordinatore | Poland [PL] |
| Totale costo | 45˙000 € |
| EC contributo | 45˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2009-RG |
| Funding Scheme | MC-ERG |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-10-01 - 2013-03-03 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Organization address
address: UL. LUDWIKA PASTEURA 3 contact info |
PL (WARSZAWA) | coordinator | 45˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'The aim of this project is to identify the microenviromental factors and their downstream cellular effectors determining the fate of adult CNS precursor cells which could be modulated in order to control remyelination process. Remyelination is the best example of regenerative processes in adult CNS, in which new myelin sheaths are restored to axons that have been demyelinated as a result of oligodendrocyte death. However, the efficiency of remyelination decreases with age and in multiple sclerosis, a disease that can afflict a patient for several decades, there is a progressive decline in remyelination. The consequence of remyelination failure is progressive loss of the chronically demyelinated axons. Therefore, there is an urgent need to understand the cellular and molecular mechanisms involved in remyelination. New oligodendrocytes are derived from proliferating oligodendrocyte precursor cells (OPCs). However, we have demonstrated, in the lineage fate mapping study, that this name does not fully reflect their differentiation potential; under appropriate conditions they can also give rise to astrocytes and Schwann cells. We demonstrated that Schwann cells, derived form OPCs, occupied almost exclusively the tissue around blood vessels in astrocyte-deficient areas. Therefore the hypothesis postulating the occurrence of specific niches creating microenvironment that regulate or determine the alternative fate of precursor cells during remyelination arises. Our vascular-niche hypothesis, which will be investigated, predicts a causative role of BMP pathway in prompting OPCs to differentiation into Schwann cells or in blocking them in the proliferation phase.'
Introduzione (Teaser)
Myelin sheaths provide insulation and structural support in neuronal axons. Understanding the molecular mechanisms of natural myelin production could help to design treatment regimes for disorders such as multiple sclerosis.