NASPE

NAnomechanical Screening of Pharmaceutical Entities

Coordinatore	UNIVERSITA DEGLI STUDI DI BRESCIA    more  Organization address address: Piazza Del Mercato 15 city: BRESCIA postcode: 25121 contact info Titolo: Prof. Nome: Laura Eleonora Cognome: Depero Email: send email Telefono: 390304000000 Fax: 390304000000
Nazionalità Coordinatore	Italy [IT]
Sito del progetto	http://www.ing.unibs.it/naspe
Totale costo	980˙202 €
EC contributo	734˙800 €
Programma	FP7-SME Specific Programme "Capacities": Research for the benefit of SMEs
Code Call	FP7-SME-2007-1
Funding Scheme	BSG-SME
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2011-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI BRESCIA  Organization address address: Piazza Del Mercato 15 city: BRESCIA postcode: 25121 contact info Titolo: Prof. Nome: Laura Eleonora Cognome: Depero Email: send email Telefono: 390304000000 Fax: 390304000000	IT (BRESCIA)	coordinator	67˙800.00
2	Hans Heinlein Werkzeug-und Formenbau GmbH  Organization address address: Angerzeile 1 city: Zirndorf postcode: 90513 contact info Titolo: Mr. Nome: Hans Cognome: Heinlein Email: send email Telefono: -607147 Fax: -604287	DE (Zirndorf)	participant	213˙000.00
3	CONCENTRIS GMBH  Organization address address: Davidsbodenstrasse 63 city: BASEL postcode: 4056 contact info Titolo: Dr. Nome: Urs Cognome: Hubler Email: send email Telefono: 41613220655 Fax: 41613220656	CH (BASEL)	participant	208˙000.00
4	NUREX s.r.l.  Organization address address: LOCALITA SERRA LI LIONI city: SASSARI postcode: 7100 contact info Titolo: Dr. Nome: Franca Cognome: Mannu Email: send email Telefono: -2677113 Fax: -2677474	IT (SASSARI)	participant	159˙500.00
5	Nome Ente NON disponibile  Organization address address: VIA CHICO MENDEZ 1 city: ERBUSCO postcode: 25030 contact info Titolo: Mr. Nome: Angelo Cognome: Di Gioia Email: send email Telefono: -7709213 Fax: -7709213	IT (ERBUSCO)	participant	49˙000.00
6	MS-Schramberg Micro GmbH & Co. KG  Organization address address: Max-Planck-Str. 15 city: Schramberg-Sulgen postcode: 78713 contact info Titolo: Mr. Nome: Armin Cognome: Schaumann Email: send email Telefono: -22544 Fax: -22544	DE (Schramberg-Sulgen)	participant	17˙500.00
7	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Giacomo Cognome: Carrea Email: send email Telefono: -28499987 Fax: -28901202	IT (ROMA)	participant	10˙000.00
8	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Ms. Nome: Andrea Cognome: Zeumann Email: send email Telefono: -3968 Fax: -773968	DE (MUENCHEN)	participant	10˙000.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Microcantilever (MC) biosensors are innovative and versatile micro-electro-mechanical systems (MEMS). Due to (nano)mechanical transduction of biochemical reactions they allow sensitive, label-free, direct, real-time and multiplexed detection of molecules as well as specific investigations of molecular interactions and conformational changes. NASPE aims at generating the pre-requisites and supporting the effort to establish MC biosensors as a competitive technology in the field of drug screening by integrating skills and know-how of SMEs and RTD performers which cover leading positions in the fields featured by the project. NASPE outcomes are expected to enable the SMEs to strengthen their position in the international market of drug discovery, to gain access to new market segments and to create new highly skilled jobs in Europe. On the other hand, NASPE research activities will contribute to address inherent fundamental issues of MEMS biosensors, including functionalization, manufacturing and novel applications. The primary aim of NASPE is structured into the following SMART objectives: - Functionalization protocols for silicon and plastic MCs, necessary for performing molecular recognition experiments by MCs. They will be accomplished by months 9 and 18, respectively, and tested on conventional fluorescent essays. - Proof-of-concept of nanomechanical drug screening by MCs, that is the necessary step for designing MC essays. Experiments for silicon and plastic MCs will be assessed and statistically validated by month 12 and month 21, respectively. - Prototype plastic MC arrays, that will be provided by month 15 and tested against commercial silicon MCs. Plastic MCs are expected to have lower cost and enhanced performances with respect to silicon MCs. - “Field” test of MC drug screening and design of drug discovery kits, that is the ultimate project objective. MC costs/benefits will be benchmarked against the commercially available drug discovery essays.'

Introduzione (Teaser)

EU-funded scientists have demonstrated for the first time the use of microscopic diving boards to detect conformational changes in adsorbed molecules. They then identified a potential drug to inhibit such a change in a target protein.