NASPE

NAnomechanical Screening of Pharmaceutical Entities

 Coordinatore UNIVERSITA DEGLI STUDI DI BRESCIA 

 Organization address address: Piazza Del Mercato 15
city: BRESCIA
postcode: 25121

contact info
Titolo: Prof.
Nome: Laura Eleonora
Cognome: Depero
Email: send email
Telefono: 390304000000
Fax: 390304000000

 Nazionalità Coordinatore Italy [IT]
 Sito del progetto http://www.ing.unibs.it/naspe
 Totale costo 980˙202 €
 EC contributo 734˙800 €
 Programma FP7-SME
Specific Programme "Capacities": Research for the benefit of SMEs
 Code Call FP7-SME-2007-1
 Funding Scheme BSG-SME
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2011-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI BRESCIA

 Organization address address: Piazza Del Mercato 15
city: BRESCIA
postcode: 25121

contact info
Titolo: Prof.
Nome: Laura Eleonora
Cognome: Depero
Email: send email
Telefono: 390304000000
Fax: 390304000000

IT (BRESCIA) coordinator 67˙800.00
2    Hans Heinlein Werkzeug-und Formenbau GmbH

 Organization address address: Angerzeile 1
city: Zirndorf
postcode: 90513

contact info
Titolo: Mr.
Nome: Hans
Cognome: Heinlein
Email: send email
Telefono: -607147
Fax: -604287

DE (Zirndorf) participant 213˙000.00
3    CONCENTRIS GMBH

 Organization address address: Davidsbodenstrasse 63
city: BASEL
postcode: 4056

contact info
Titolo: Dr.
Nome: Urs
Cognome: Hubler
Email: send email
Telefono: 41613220655
Fax: 41613220656

CH (BASEL) participant 208˙000.00
4    NUREX s.r.l.

 Organization address address: LOCALITA SERRA LI LIONI
city: SASSARI
postcode: 7100

contact info
Titolo: Dr.
Nome: Franca
Cognome: Mannu
Email: send email
Telefono: -2677113
Fax: -2677474

IT (SASSARI) participant 159˙500.00
5    Nome Ente NON disponibile

 Organization address address: VIA CHICO MENDEZ 1
city: ERBUSCO
postcode: 25030

contact info
Titolo: Mr.
Nome: Angelo
Cognome: Di Gioia
Email: send email
Telefono: -7709213
Fax: -7709213

IT (ERBUSCO) participant 49˙000.00
6    MS-Schramberg Micro GmbH & Co. KG

 Organization address address: Max-Planck-Str. 15
city: Schramberg-Sulgen
postcode: 78713

contact info
Titolo: Mr.
Nome: Armin
Cognome: Schaumann
Email: send email
Telefono: -22544
Fax: -22544

DE (Schramberg-Sulgen) participant 17˙500.00
7    CONSIGLIO NAZIONALE DELLE RICERCHE

 Organization address address: Piazzale Aldo Moro 7
city: ROMA
postcode: 185

contact info
Titolo: Dr.
Nome: Giacomo
Cognome: Carrea
Email: send email
Telefono: -28499987
Fax: -28901202

IT (ROMA) participant 10˙000.00
8    FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V

 Organization address address: Hansastrasse 27C
city: MUENCHEN
postcode: 80686

contact info
Titolo: Ms.
Nome: Andrea
Cognome: Zeumann
Email: send email
Telefono: -3968
Fax: -773968

DE (MUENCHEN) participant 10˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

discovery    experiments    mcs    essays    naspe    drug    functionalization    screening    time    smes    market    conformational    tested    mc    molecules    respectively    mems    plastic    biosensors    molecular    mechanical    silicon   

 Obiettivo del progetto (Objective)

'Microcantilever (MC) biosensors are innovative and versatile micro-electro-mechanical systems (MEMS). Due to (nano)mechanical transduction of biochemical reactions they allow sensitive, label-free, direct, real-time and multiplexed detection of molecules as well as specific investigations of molecular interactions and conformational changes. NASPE aims at generating the pre-requisites and supporting the effort to establish MC biosensors as a competitive technology in the field of drug screening by integrating skills and know-how of SMEs and RTD performers which cover leading positions in the fields featured by the project. NASPE outcomes are expected to enable the SMEs to strengthen their position in the international market of drug discovery, to gain access to new market segments and to create new highly skilled jobs in Europe. On the other hand, NASPE research activities will contribute to address inherent fundamental issues of MEMS biosensors, including functionalization, manufacturing and novel applications. The primary aim of NASPE is structured into the following SMART objectives: - Functionalization protocols for silicon and plastic MCs, necessary for performing molecular recognition experiments by MCs. They will be accomplished by months 9 and 18, respectively, and tested on conventional fluorescent essays. - Proof-of-concept of nanomechanical drug screening by MCs, that is the necessary step for designing MC essays. Experiments for silicon and plastic MCs will be assessed and statistically validated by month 12 and month 21, respectively. - Prototype plastic MC arrays, that will be provided by month 15 and tested against commercial silicon MCs. Plastic MCs are expected to have lower cost and enhanced performances with respect to silicon MCs. - “Field” test of MC drug screening and design of drug discovery kits, that is the ultimate project objective. MC costs/benefits will be benchmarked against the commercially available drug discovery essays.'

Introduzione (Teaser)

EU-funded scientists have demonstrated for the first time the use of microscopic diving boards to detect conformational changes in adsorbed molecules. They then identified a potential drug to inhibit such a change in a target protein.

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