SYBOSS

Systems Biology of Stem Cells and Reprogramming

 Coordinatore TECHNISCHE UNIVERSITAET DRESDEN 

 Organization address address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069

contact info
Titolo: Mr.
Nome: Sven
Cognome: Kreigenfeld
Email: send email
Telefono: 4935150000000
Fax: 4935150000000

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://syboss.eu/
 Totale costo 13˙670˙200 €
 EC contributo 10˙530˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2009-two-stage
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-06-01   -   2015-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET DRESDEN

 Organization address address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069

contact info
Titolo: Mr.
Nome: Sven
Cognome: Kreigenfeld
Email: send email
Telefono: 4935150000000
Fax: 4935150000000

DE (DRESDEN) coordinator 4˙004˙403.50
2 KOBENHAVNS UNIVERSITET DK participant 1˙101˙335.20
3    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Prof.
Nome: Claude
Cognome: Huriet
Email: send email
Telefono: +33 1 56 24 40 54
Fax: +33 1 56 24 4054

FR (PARIS) participant 871˙600.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Prof.
Nome: Frank
Cognome: Grosveld
Email: send email
Telefono: +31 10 7043169
Fax: +31 10 7044743

NL (ROTTERDAM) participant 860˙560.00
5    GENOME RESEARCH LIMITED

 Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Mr.
Nome: David
Cognome: Davison
Email: send email
Telefono: +44 1223 494937
Fax: +44 1223 494919

UK (LONDON) participant 745˙280.00
6    DANMARKS TEKNISKE UNIVERSITET

 Organization address address: Anker Engelundsvej 1, Building 101A
city: KONGENS LYNGBY
postcode: 2800

contact info
Titolo: Ms.
Nome: Kristina
Cognome: Holdgaard-Sørensen
Email: send email
Telefono: +45 2516 1403
Fax: +45 4524 9031

DK (KONGENS LYNGBY) participant 722˙480.00
7    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Jürgen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022
Fax: +49 89 3187 3866

DE (MUENCHEN) participant 542˙559.50
8    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Birgit
Cognome: Knepper-Nicolai
Email: send email
Telefono: 493512000000
Fax: 493512000000

DE (MUENCHEN) participant 493˙440.00
9    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Mr.
Nome: Keith
Cognome: Cann
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

UK (CAMBRIDGE) participant 434˙200.00
10    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Ms.
Nome: Genevieve
Cognome: Reinke
Email: send email
Telefono: +49 6221 3878153
Fax: +49 6221 3878301

DE (HEIDELBERG) participant 397˙625.30
11    KLINIKUM DER UNIVERSITAET ZU KOELN

 Organization address address: Kerpener Strasse 62
city: KOELN
postcode: 50937

contact info
Titolo: Mrs.
Nome: Petra
Cognome: Schreiner-Kaub
Email: send email
Telefono: +49 221 478 98413
Fax: +49 221 478 1498413

DE (KOELN) participant 356˙516.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

differentiate    transcriptomic    health    fundamental    implications    skin    reprogrammed    ns    cells    central    regenerative    recently    ageing    disabilities    es    embryonic    stem    neural    breakthrough    data    cell    pluripotent    diseases    therapy    medicine    types    degenerative    retain    proteomic    acquire    selected    tissue    cancer    syboss    somatic    mescs    boosted    gather    datasets    biology   

 Obiettivo del progetto (Objective)

'Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases. Recently the prospects for regenerative therapy have been boosted by the breakthrough finding that somatic cells can be reprogrammed into pluripotent embryonic stem (ES) cells upon expression of ES cell transcription factors. This astonishing finding further emphasizes the need to understand stem cell biology. Most of the information acquired on stem cells so far is empirical. Recent progress in systematic and computational methodologies, including seminal contributions by the applicants, permits a new approach to stem cell biology. We can now describe the systems biology of stem cells. This proposal is based on the importance of stem cells in future medicine and the need to understand the fundamental mechanisms that regulate their potential to differentiate towards specific lineages. We aim to gather the information required to understand the regulomes of key stem cells, particularly the transition between embryonic (ES) and neural (NS) cells. NS cells can be readily reprogrammed back to ES cells. We will systematically gather proteomic, transcriptomic, regulomic, live cell and cell cycle data to understand the ES – NS axis comprehensively (in both directions). We will validate the regulatory data by functional interrogation using RNAi screens and tests, complemented by quantitative fluorescent read-outs. To broaden the fundamental and medical relevance of the insights, we will pursue selected studies on other stem cells (e.g. HSCs), and their differentiated products. Thereby we will acquire a broader grasp on stem cell issues and also significantly advance mammalian systems biology.'

Introduzione (Teaser)

Recently, regenerative therapy has been boosted by the breakthrough finding that normal body cells, somatic cells, can be reprogrammed into pluripotent embryonic stem (ES) cells.

Descrizione progetto (Article)

Stem cells are central to emerging concepts in health, medicine and therapy. Specific somatic cells retain the ability for tissue growth and repair. This has implications for both regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases.

That somatic cells can be reprogrammed to behave like ES cells further emphasises the need to elucidate stem cell biology.

The EU-funded 'Systems biology of stem cells and reprogramming' (http://syboss.eu/ (SYBOSS)) project is dedicated to gathering data to build a systems biology understanding of stem cells. A key property of stem cells is their capacity to develop or differentiate into specific cell types that lose their multi-potency but acquire cell type-specific characteristics. So a skin cell has specifically skin cell characteristics.

SYBOSS is also applying a systems biology approach to study selected stagesbetween the multi-potent stem cell state and the final cell form .

Mouse embryonic stem cells (mESCs) maintain genome stability and physiological normality. They can develop into other cell types, which can be reprogrammed into mESCs using induced pluripotency technology. SYBOSS is working with mESCs and focusing on their differentiation into neural (nerve) stem cells (NSCs).

Data hae been gathered for total cellular datasets and gene-specific datasets. Integrated transcriptomic, proteomic and epigenomic analyses of different cell states are now approaching completion.

SYBOSS data will be important for developing standards for cell-based therapies. The broadest socioeconomic impact of the project relates to the development of new ways to treat chronic disabilities in the human population, particularly those related to ageing, as well as genetically based disabilities or degenerative diseases.

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MOMI (2011)

Missed Opportunities in Maternal and Infant Health: reducing maternal and newborn mortality and morbidity in the year after childbirth through combined facility- and community-based interventions

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FIGHT-HLH (2012)

First Targeted Therapy to FIGHT Hemophagocytic Lymphohistiocytosis (HLH): A novel approach to HLH

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NOTOX (2011)

Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures

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