SECMESSBIOFILM
Cyclic-di-GMP: New Concepts in Second Messenger Signaling and Bacterial Biofilm Formation
| Coordinatore | HUMBOLDT-UNIVERSITAT ZU BERLIN
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 1˙998˙000 € |
| EC contributo | 1˙998˙000 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2009-AdG |
| Funding Scheme | ERC-AG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-06-01 - 2015-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FREIE UNIVERSITAET BERLIN
Organization address
address: Kaiserswertherstrasse 16-18 contact info |
DE (BERLIN) | beneficiary | 959˙984.00 |
| 2 |
HUMBOLDT-UNIVERSITAT ZU BERLIN
Organization address
address: UNTER DEN LINDEN 6 contact info |
DE (BERLIN) | hostInstitution | 1˙038˙016.00 |
| 3 |
HUMBOLDT-UNIVERSITAT ZU BERLIN
Organization address
address: UNTER DEN LINDEN 6 contact info |
DE (BERLIN) | hostInstitution | 1˙038˙016.00 |
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Obiettivo del progetto (Objective)
'Biofilms represent a multicellular lifestyle of bacteria that causes serious biomedical and technological problems. Biofilm developmental involves an inhibition of motility and an induction of adhesins at the cell surface and culminates in complex structures, in which bacteria are embedded in an extracellular matrix, which renders them resistant against antibiotics and host immune systems. The overall objective of the proposed project is to clarify nature and nurture in bacterial biofilm formation, i.e. to reveal the underlying genetic control network and its integration with environmentally responsive pathways that influence biofilm composition and architecture. The major working hypothesis of this proposal is that the ubiquitously biofilm-stimulating second messenger c-di-GMP and the many proteins associated with its synthesis, degradation and action are mainly responsible for this integration (i) by providing the molecular switches that establish the metastable states characteristic for biofilm development, and (ii) by integrating many of the environmental signals that modulate biofilm composition and architecture. Even in single species, c-di-GMP is produced and degraded by multiple diguanylate cyclases (GGDEF domain proteins) and phosphodiesterases (EAL domain proteins), respectively. This project will elucidate the regulation, function, cooperation and targets of all 29 GGDEF/EAL domain proteins during the entire series of molecular events that generates a biofilm of the model organism Escherichia coli, which includes commensals as well as important pathogens. As c-di-GMP is used by virtually all bacteria, understanding its production and mode of action will open new and general perspectives for interference with bacterial biofilm formation.'