GABACELLSANDMEMORY

Linking GABAergic neurones to hippocampal-entorhinal system functions

 Coordinatore UNIVERSITAETSKLINIKUM HEIDELBERG 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙872˙000 €
 EC contributo 1˙872˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-07-01   -   2015-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Ms.
Nome: Julia
Cognome: Feuerer
Email: send email
Telefono: +49 6221 567597
Fax: +49 6221 565460

DE (HEIDELBERG) hostInstitution 1˙872˙000.00
2    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Prof.
Nome: Hannelore
Cognome: Monyer
Email: send email
Telefono: +49 6221423101
Fax: +49 6221423111

DE (HEIDELBERG) hostInstitution 1˙872˙000.00

Mappa


 Word cloud

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coding    rate    memory    cells    representation    network    entorhinal    cortex    affect    hippocampal    modified    oscillations    recruitment    hippocampus    spatial    us    theta    interneurones    gabaergic    pyramidal   

 Obiettivo del progetto (Objective)

'GABAergic interneurones can effectively synchronize the activity of principal cells giving rise to distinct oscillatory patterns. A particular rhythm, hippocampal theta oscillations (6-10Hz), links two ways of coding by which pyramidal cells in the hippocampus represent space, namely rate and phase coding. Thus, the theta cycle provides a clock against which the increased firing rate of pyramidal cells in the hippocampus and entorhinal cortex is measured. Furthermore, hippocampal theta is believed to constitute a link to episodic memory. Recent evidence from our lab indicates that recruitment of GABAergic interneurones critically affects certain aspects of hippocampus-dependent spatial memory in mice. We have established genetic tools that allow us to manipulate GABAergic interneurones in a cell type and region-specific manner. In combination with in vivo electrophysiology in the hippocampus/entorhinal cortex and behavioural studies, we will investigate how GABAergic interneurones regulate the activity in neuronal networks and contribute to behaviour. Specifically, we will address the following questions: 1) How does reduced recruitment of GABAergic interneurones affect network activity (theta oscillations)? 2) How does altered activity of GABAergic interneurones affect spatial representation (activity of place cells in the hippocampus and grid cells in the entorhinal cortex)? 3) How does modified activity in the hippocampus affect activity in the entorhinal cortex (and vice versa)? 4) How does modified network activity and spatial representation translate into spatial memory? The interdisciplinary approach will enable us to provide better insight into how cellular activity of GABAergic interneurones relates to network activity and ultimately to behaviour.'

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