ANGIOTOX

"Histopathologic and Mechanistic Assessment of Angiogenesis Inhibitor Related Toxicities: A Cross-Sectoral, Multi-disciplinary Approach."

 Coordinatore ROYAL COLLEGE OF SURGEONS IN IRELAND 

 Organization address address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
Nome: Barry
Cognome: Mcgowan
Email: send email
Telefono: +353 1 4022478
Fax: +53 1 4022450

 Nazionalità Coordinatore Ireland [IE]
 Totale costo 1˙762˙399 €
 EC contributo 1˙762˙399 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IAPP
 Funding Scheme MC-IAPP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-07-01   -   2014-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND

 Organization address address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
Nome: Barry
Cognome: Mcgowan
Email: send email
Telefono: +353 1 4022478
Fax: +53 1 4022450

IE (DUBLIN) coordinator 435˙052.00
2    OncoMark Limited

 Organization address address: Weston Park 76
city: DUBLIN 14
postcode: -

contact info
Titolo: Dr.
Nome: Mairin
Cognome: Rafferty
Email: send email
Telefono: +353 1 7163666
Fax: +353 1 716 3709

IE (DUBLIN 14) participant 493˙891.00
3    PATHOLOGY EXPERTS GMBH

 Organization address address: HAUPTSTRASSE 90
city: BINNINGEN
postcode: 4102

contact info
Titolo: Dr.
Nome: Maurice
Cognome: Cary
Email: send email
Telefono: 41614220929
Fax: 41614220931

CH (BINNINGEN) participant 182˙098.00
4    STICHTING VU-VUMC

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Henk
Cognome: Verheul
Email: send email
Telefono: 31204444321
Fax: 31204444079

NL (AMSTERDAM) participant 161˙134.00
5    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: +353 1 7161656
Fax: +353 1 7161216

IE (DUBLIN) participant 156˙993.00
6    F. HOFFMANN-LA ROCHE AG

 Organization address address: GRENZACHERSTRASSE 124
city: BASEL
postcode: 4070

contact info
Titolo: Dr.
Nome: Stefan
Cognome: Scherer
Email: send email
Telefono: +1 650 467 4643
Fax: +41 61 6883030

CH (BASEL) participant 141˙847.00
7    Genentech Inc.

 Organization address address: DNA WAY 1
city: SOUTH SAN FRANCISCO CA
postcode: 94080

contact info
Titolo: Dr.
Nome: Priti
Cognome: Hegde
Email: send email
Telefono: +1 650 225 6145
Fax: +1 650 952 9881

US (SOUTH SAN FRANCISCO CA) participant 113˙866.00
8    BAYER TECHNOLOGY SERVICES GMBH

 Organization address address: Kaiser-Wilhelm-Allee
city: LEVERKUSEN
postcode: 51368

contact info
Nome: Peter
Cognome: Steudtner
Email: send email
Telefono: +49 214 3065634

DE (LEVERKUSEN) participant 77˙518.00
9    BAYER SCHWEIZ AG

 Organization address address: GRUBENSTRASSE 6
city: ZURICH
postcode: 8045

contact info
Titolo: Dr.
Nome: Gerhard.M.
Cognome: Kresbach
Email: send email
Telefono: +41 61 7268183
Fax: +41 61 726 8170

CH (ZURICH) participant 0.00
10    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Henk
Cognome: Verheul
Email: send email
Telefono: 31204444321
Fax: 31204444079

NL (AMSTERDAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

inhibitors    academic    industry    treatment    mechanistic    clinical    vivo    markers    inhibitor    toxicity    drug    toxicologic    toxicities    angiotox    pathways    angiogenesis   

 Obiettivo del progetto (Objective)

'Inhibition of angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a well established therapeutic strategy against cancer. Inhibitors of angiogenesis have been developed to block tumour growth and metastasis, and a number of these inhibitors are now clinically approved. However, contrary to initial expectations, angiogenesis inhibitors can cause a range of toxicities in patients. AngioTox is a cross-sectoral collaboration in the field of biomedicine, responding to a pressing need to understand mechanisms of toxicity associated with angiogenesis inhibitor treatment. AngioTox is comprised of academic groups, SMEs, a global pharmaceutical leader in angiogenesis inhibitor development, and a large company concerned with monitoring drug modulation of cellular pathways. The goal of this consortium is to facilitate comprehensive histopathologic and mechanistic assessment of angiogenesis inhibitor related toxicities following treatment with the two main class of angiogenesis inhibitor; monoclonal antibodies and tyrosine kinase inhibitors. A combined in vivo modelling and digital histopathology approach will be engaged to comprehensively describe a new AngioTox Safety Panel of toxicologic markers. We will develop automated image analysis algorithms to enable quantification of morphological markers of angiogenesis inhibitor toxicity, and will undertake molecular profiling and ex-vivo studies to gain insight into mechanistic pathways. Specialized secondments proposed within AngioTox will facilitate several opportunities for high-end training of researchers across both industry and academia. Findings from the AngioTox programme may be directly utilised by academic, clinical and industry-based investigators to facilitate improved screening of angiogenesis inhibitor toxicologic parameters, inform clinical drug dosing regimens, facilitate the development of more specific and potent angiogenesis inhibitors, and significantly improve patient care.'

Altri progetti dello stesso programma (FP7-PEOPLE)

SHEEPMILKGENES (2008)

High resolution mapping of a QTL region influencing fat percentage in Spanish Churra dairy sheep

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SEES (2009)

Super Energy Efficient Structures

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METASTASIS (2011)

Evaluation of metastatic and angiogenic potential of cancer stem-like cells in distinct mouse models for lung and liver metastasis

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