ABETACOGNITION

The functional significance of soluble amyloid beta (Abeta) oligomers for learning and memory deficits in Alzheimer's disease

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Hartmut
Cognome: Lingner
Email: send email
Telefono: +49 89 30622330
Fax: +49 89 30622372

 Nazionalità Coordinatore Germany [DE]
 Totale costo 161˙661 €
 EC contributo 161˙661 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-01-01   -   2013-11-07

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Hartmut
Cognome: Lingner
Email: send email
Telefono: +49 89 30622330
Fax: +49 89 30622372

DE (MUENCHEN) coordinator 161˙661.00

Mappa

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cognitive    ad    brain    scientific    abeta    neuronal    learning    vitro    progression    effect    effort    gradual    alzheimer    decline    arc    disease    unknown    mice    affected    memory    soluble   

 Obiettivo del progetto (Objective)

'Alzheimer’s disease (AD) is characterised by a gradual cognitive decline, which initially affects learning and memory, and gradually impairs other cognitive functions. Despite considerable scientific effort, the cause and pathogenesis of AD is still unknown. Recent in vitro studies suggest that the destruction of synapses by soluble aggregates of amyloid beta (Abeta) might play a role in mediating the progression of the disease. However, what is lacking is an approach that establishes the links between cellular pathology, its causative effect on neuronal network activity in the affected brain areas, and the resulting behavioural impairments. This project aims to address this shortcoming by using a cross-disciplinary design. Core to this project are novel transgenic mice overexpressing soluble (Abeta), which will be tested on object and spatial recognition memory tasks. A novel imaging technique, manganese-enhanced MRI, will be used to establish the effect that soluble (Abeta) has on neuronal activity in the perirhinal cortex and hippocampus, brain areas that are affected early in AD and mediate these types of memory. Lastly, we aim to investigate whether memory deficits in arc(Abeta) mice can be abolished by inhibitors that target elements of (Abeta)-activated signalling cascades recently established in vitro. This will be achieved by direct infusion of drugs into the brain regions of interest in freely behaving arc(Abeta) mice, with the aim of identifying new targets for pharmacotherapeutic intervention. The fellowship at the Max-Planck-Institute for Psychiatry in Munich will enable the applicant, who has received excellent training in the basic field of learning and memory at Oxford and Cambridge, to acquire additional competencies focused on the neuroscience of neuropsychiatric disorders. By moving from the UK to Germany, the fellow will help to circulate scientific knowledge within the European Research Area, towards a common European effort to tackle one of today’s least understood diseases.'

Introduzione (Teaser)

The cause of Alzheimer's disease (causing gradual cognitive decline and eventual loss of cognitive function) is still unknown. Studying the mechanism of the onset and early stages of the disease can lead to reversing or slowing down its progression.

Altri progetti dello stesso programma (FP7-PEOPLE)

SUPRA-DYN (2010)

Dynamics of Soft Metallo-Supramolecular Materials from Entangled Macromolecular Precursors

Read More  

ATLASTTH (2014)

Observation of the Higgs production mode in the ttH channel at ATLAS

Read More  

INNOSTORAGE (2013)

USE OF INNOVATIVE THERMAL ENERGY STORAGE FOR MARKED ENERGY SAVINGS AND SIGNIFICANT LOWERING OF CO2 EMISSIONS

Read More