Stimulated Raman analysis and Raman microscopy with Fourier Domain Mode Locked (FDML) laser sources


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 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙168˙058 €
 EC contributo 1˙168˙058 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2010-StG_20091028
 Funding Scheme ERC-SG
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-01-01   -   2015-12-31


# participant  country  role  EC contrib. [€] 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
postcode: 80539

contact info
Titolo: Dr.
Nome: Robert Alexander
Cognome: Huber
Email: send email
Telefono: +49 89 2180 9235
Fax: +49 89 2180 9202

DE (MUENCHEN) hostInstitution 1˙168˙058.00

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
postcode: 80539

contact info
Titolo: Ms.
Nome: Monika
Cognome: Bernhardt
Email: send email
Telefono: +49 89 21803449
Fax: +49 89 21802985

DE (MUENCHEN) hostInstitution 1˙168˙058.00


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techniques    spectral    stimulated    strategies    contrast    signal    lasers    spectroscopy    fdml    detection    raman    physical    sensitive    microscopy   

 Obiettivo del progetto (Objective)

'Raman spectroscopy is one of the most specific non-destructive optical techniques to identify the chemical composition of a sample. Further, there is great hope that in the future it may be a powerful biomedical imaging technique for in vitro or in vivo microscopy, providing molecular contrast without exogenous contrast agents.

However, due to the small Raman cross-section, for many applications the acquisition is prohibitively slow. Techniques to solve this problem and to increase the Raman signal levels are coherent anti-Stokes Raman spectroscopy (CARS), surface enhanced Raman spectroscopy (SERS) and stimulated Raman spectroscopy (SRS). However, in many cases, they are currently not able to provide rapid, highly sensitive detection of an undistorted signal with a broad spectral coverage.

The aim of the project is to investigate Fourier domain mode locked (FDML) lasers for the application to stimulated Raman detection. A variety of physical effects, unique to FDML lasers, enables strategies to substantially increase the Raman signal level. This can provide access to highly sensitive Raman spectroscopy and high speed Raman microscopy. The techniques to increase the detection sensitivity include concepts like single- and double-resonant enhancement cavities, high power fibre amplification, dynamic spectral zooming, advanced modulation schemes and parallel designs.

The first part of the project addresses a comprehensive understanding of the underlying physical effects and how to increase the Raman signal by several orders of magnitude using these various strategies. The aim of the second part is to investigate, in how far these improved FDML based Raman systems can be applied to transient real time spectroscopy, analytical sensing, and Raman microscopy.'

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