CESICOP

Elucidating the control of cell size in plants

 Coordinatore UNIVERSITAET POTSDAM 

 Organization address address: AM NEUEN PALAIS 10
city: POTSDAM
postcode: 14469

contact info
Titolo: Dr.
Nome: Regina
Cognome: Gerber
Email: send email
Telefono: +49 331 9771080
Fax: +49 331 9771298

 Nazionalità Coordinatore Germany [DE]
 Totale costo 169˙969 €
 EC contributo 169˙969 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-10-01   -   2012-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET POTSDAM

 Organization address address: AM NEUEN PALAIS 10
city: POTSDAM
postcode: 14469

contact info
Titolo: Dr.
Nome: Regina
Cognome: Gerber
Email: send email
Telefono: +49 331 9771080
Fax: +49 331 9771298

DE (POTSDAM) coordinator 169˙969.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

kinesin    enlargement    cell    excess    expansion    plants    uneven    ploidy    analyzing    protein    size    synthesis    golgi    hypothesis    material    wall    stacks   

 Obiettivo del progetto (Objective)

'Cell size is a crucial determinant of overall organ size. The size of a cell can be influenced by various hormones; it depends on the identity of the cell; and it is positively correlated with the cell’s ploidy level. However, the molecular mechanisms that determine when cell expansion stops to ensure an appropriate cell size are poorly understood. In plants, the presence of a cell wall means that the extent of cell expansion, and thus the amount of cell wall synthesized, is also of paramount economic importance, given our dependence on plant cell-wall material for classical uses (paper, textiles, etc.) and for bioenergy production. The Lenhard group have recently isolated mutations in an Arabidopsis kinesin, a microtubule-based motor protein, that lead to larger cells despite normal ploidy levels. The kinesin associates with Golgi-stacks and appears necessary to ensure their even distribution within the cell. Given the importance of the Golgi-apparatus for secretion of cell-wall material, the current working hypothesis is that more uneven cell-wall biosynthesis in the mutants resulting from the uneven distribution of the Golgi-stacks triggers cell-wall integrity-sensing pathways, which in turn lead to the synthesis of more cell wall and excess cell expansion. This proposal will address the basic function of the identified kinesin by analyzing plants lacking also a highly similar, probably functionally redundant kinesin; study the mechanism of action of the kinesin in question by analyzing an identified interacting protein; assess the cellular basis for the observed cell enlargement by testing several of the assumptions and predictions of the working hypothesis outlined above; and investigate the relation between the excess cell enlargement in the kinesin mutant and that seen in the phenomenon of ‘compensation’. Together, these studies will provide important new insight into the regulation of cell-wall synthesis and cell expansion in plants.'

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