Explore the words cloud of the MIROCALS project. It provides you a very rough idea of what is the project "MIROCALS" about.
The following table provides information about the project.
CENTRE HOSPITALIER UNIVERSITAIRE
|Coordinator Country||France [FR]|
|Total cost||6˙510˙741 €|
|EC max contribution||5˙980˙435 € (92%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2015-09-01 to 2021-09-30|
Take a look of project's partnership.
|1||CENTRE HOSPITALIER UNIVERSITAIRE||FR (NIMES)||coordinator||1˙448˙890.00|
|2||THE UNIVERSITY OF SUSSEX||UK (BRIGHTON)||participant||856˙330.00|
|3||ICON CLINICAL RESEARCH LIMITED||IE (DUBLIN)||participant||659˙105.00|
|4||THE UNIVERSITY OF SHEFFIELD||UK (SHEFFIELD)||participant||504˙408.00|
|5||KING'S COLLEGE LONDON||UK (LONDON)||participant||490˙790.00|
|6||WGK CONSULTANCY LTD||UK (STEVENAGE)||participant||476˙650.00|
|7||HUMANITAS MIRASOLE SPA||IT (ROZZANO (MI))||participant||450˙000.00|
|8||INSERM - TRANSFERT SA||FR (PARIS)||participant||421˙000.00|
|9||ASSOCIATION GENETHON||FR (EVRY)||participant||373˙622.00|
|10||QUEEN MARY UNIVERSITY OF LONDON||UK (LONDON)||participant||159˙138.00|
|11||GOETEBORGS UNIVERSITET||SE (GOETEBORG)||participant||140˙500.00|
|12||MOTOR NEURONE DISEASE ASSOCIATION||UK (NORTHAMPTON)||participant||0.00|
Amyotrophic Lateral Sclerosis (ALS) is a fatal degenerative disorder of the brain and spinal cord affecting some 40,000 individuals in Europe, causing 11,000 deaths each year. Our pioneering work on riluzole showed that it is possible to modify ALS progression but all subsequent trials of potential neuroprotective agents have failed. Thus, drug development in ALS, including trial design, patient selection, and outcome measures must be re-engineered to break the current impasse. Nerve cell death in ALS is associated with inflammation, which contributes to cell damage, and is a logical target for therapy. Although therapeutic attempts to modify this have failed so far, the discovery of regulatory T cells (Tregs) as key players in controlling inflammatory processes opens new possibilities since defective Treg function is important in ALS. In fact, Treg numbers and function predict rates of disease progression and survival. Low-dose interleukin-2 (ld IL-2) safely and specifically increases and activates Tregs in conditions such as type 1 diabetes, HBc-vasculitis and chronic graft-versus-host disease, so ld IL-2 has the potential to significantly improve survival and deliver a therapeutic breakthrough in ALS. We also integrate biomarkers for nerve cell damage into the trial design to provide proof of concept/mechanism. “Modifying Immune Response and OutComes in ALS” (MIROCALS) will test the hypothesis that ld IL-2-induced increases in Tregs result in decreased rates of nerve cell damage and that this effect can be detected early in the course of the disease using a range of blood and cerebrospinal fluid biomarkers. Our ambition is to develop a new therapy for ALS and through this novel trial design break the impasse in drug development of other disease-modifying agents in ALS. The impact will be to enhance quality of life and care for people with ALS, and provide a robust model for Industry to encourage investment in ALS and other neurodegenerative diseases.
|Approval from IRBs and Regulatory Agencies||Documents, reports||2020-02-17 17:47:48|
|Corporate communication tools provided||Demonstrators, pilots, prototypes||2020-02-17 17:47:48|
Take a look to the deliverables list in detail: detailed list of MIROCALS deliverables.
|year||authors and title||journal||last update|
Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick
Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis
published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-019-0698-2
|Acta Neuropathologica Communications 7/1||2020-04-15|
Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Cop
Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases
published pages: , ISSN: 1750-1326, DOI: 10.1186/s13024-018-0270-8
|Molecular Neurodegeneration 13/1||2020-02-17|
Sarah Morgan, Aleksey Shatunov, William Sproviero, Ashley R. Jones, Maryam Shoai, Deborah Hughes, Ahmad Al Khleifat, Andrea Malaspina, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Katie Sidle, Richard W. Orrell, Pietro Fratta, John Hardy, Alan Pittman, Ammar Al-Chalabi
A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK
published pages: 1611-1618, ISSN: 0006-8950, DOI: 10.1093/brain/awx082
Janine Kirby, Afnan Al Sultan, Rachel Waller, Paul Heath
The genetics of amyotrophic lateral sclerosis: current insights
published pages: 49, ISSN: 1179-9900, DOI: 10.2147/dnnd.s84956
|Degenerative Neurological and Neuromuscular Disease||2020-02-17|
Martina de Majo, Simon D. Topp, Bradley N. Smith, Agnes L. Nishimura, Han-Jou Chen, Athina Soragia Gkazi, Jack Miller, Chun Hao Wong, Caroline Vance, Frank Baas, Anneloor L.M.A. ten Asbroek, Kevin P. Kenna, Nicola Ticozzi, Alberto Garcia Redondo, JesÃºs Esteban-PÃ©rez, Cinzia Tiloca, Federico Verde, Stefano Duga, Karen E. Morrison, Pamela J. Shaw, Janine Kirby, Martin R. Turner, Kevin Talbot, Orla
ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
published pages: 266.e1-266.e10, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.06.015
|Neurobiology of Aging 71||2020-02-17|
Sarah Martin, Emma Trevor-Jones, Sabyha Khan, Keelan Shaw, Deepti Marchment, Anna Kulka, Catherine E Ellis, Rachel Burman, Martin R. Turner, Liam Carroll, Leah Mursaleen, P. Nigel Leigh, Christopher E. Shaw, Neil Pearce, Daniel Stahl, Ammar Al-Chalabi
The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison
published pages: 569-575, ISSN: 2167-8421, DOI: 10.1080/21678421.2017.1349151
|Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18/7-8||2020-02-17|
Alice Vajda, Russell L. McLaughlin, Mark Heverin, Owen Thorpe, Sharon Abrahams, Ammar Al-Chalabi, Orla Hardiman
Genetic testing in ALS
published pages: 991-999, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003686
Egor Dolzhenko, Joke J.F.A. van Vugt, Richard J. Shaw, Mitchell A. Bekritsky, Marka van Blitterswijk, Giuseppe Narzisi, Subramanian S. Ajay, Vani Rajan, Bryan R. Lajoie, Nathan H. Johnson, Zoya Kingsbury, Sean J. Humphray, Raymond D. Schellevis, William J. Brands, Matt Baker, Rosa Rademakers, Maarten Kooyman, Gijs H.P. Tazelaar, Michael A. van Es, Russell McLaughlin, William Sproviero, Aleksey Sha
Detection of long repeat expansions from PCR-free whole-genome sequence data
published pages: 1895-1903, ISSN: 1088-9051, DOI: 10.1101/gr.225672.117
|Genome Research 27/11||2020-02-17|
Zhongbo Chen, Kuang Lin, Jeffrey D. Macklis, Ammar Al-Chalabi
Proposed association between the hexanucleotide repeat of C9orf72 and opposability index of the thumb
published pages: 175-181, ISSN: 2167-8421, DOI: 10.1080/21678421.2016.1257024
|Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18/3-4||2020-02-17|
Ton Fang, Ahmad Al Khleifat, Jacques-Henri Meurgey, Ashley Jones, P Nigel Leigh, Gilbert Bensimon, Ammar Al-Chalabi
Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
published pages: 416-422, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(18)30054-1
|The Lancet Neurology 17/5||2020-02-17|
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The information about "MIROCALS" are provided by the European Opendata Portal: CORDIS opendata.
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