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ImmunoAgeing SIGNED

An integrated approach to dissect determinants, risk factors and pathways of ageing of the immune system.

Total Cost €

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EC-Contrib. €

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Partnership

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 ImmunoAgeing project word cloud

Explore the words cloud of the ImmunoAgeing project. It provides you a very rough idea of what is the project "ImmunoAgeing" about.

age    systematically    contractions    alcohol    quantify    infections    immune    inflammatory    cell    circulating    life    detrimental    facilitated    ageing    point    reveal    smoking    prevention    biomarkers    immunosenescence    unknown    subtypes    autoantibodies    environmental    notably    critical    analysed    resolution    greatest    genetic    elucidate    autoreactivity    bioresources    diagnosis    population    experiments    mechanisms    diet    shifts    intake    activated    transcriptional    epidemiological    volunteers    transmissible    supplemented    style    sorted    choices    populations    molecules    routes    viral    huge    targetted    underlying    followed    cohorts    dysfunction    largely    140    levels    unprecedented    exposure    alleviation    centres    participating    function    types    health    correlation    physical    complementary    responsiveness    25    eventual    cells    profiles    expertise    antibodies    repertoire    genetically    cytokines    capitalising    specificity   

Project "ImmunoAgeing" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Italy [IT]
 Project website http://www.immunoageing.eu/
 Total cost 5˙850˙000 €
 EC max contribution 5˙850˙000 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 2˙514˙062.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 2˙227˙855.00
3    UNIVERSITAET INNSBRUCK AT (INNSBRUCK) participant 700˙000.00
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 208˙082.00
5    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU IT (SIENA) participant 200˙000.00

Map

 Project objective

Age-related changes in the immune system, also known as ‘immunosenescence’, have a huge detrimental impact on the health of our ageing populations. However, the extent and mechanisms of the changes, and thus possible routes to prevention or alleviation, are largely unknown. We propose to analyse immunosenescence with unprecedented resolution by determining in large cohorts of volunteers the changes with age in circulating levels of ~140 subtypes of immune system cells and ~25 immune molecules, including cytokines and antibodies. We will also quantify age-related immune dysfunction, and notably autoreactivity, by determining the specificity and level of key circulating autoantibodies and their correlation with contractions in the B & T cell repertoire in our large general population ageing cohorts. Underlying genetic and major environmental factors -- including life style choices like smoking, diet, alcohol intake and, physical activity as well as transmissible viral infections -- will be systematically analysed. The analyses will build on our studies on levels of immune system cell subsets and inflammatory biomarkers in genetically well characterized population cohorts, and will be followed up by examining sorted circulating cells for ageing-related shifts in transcriptional profiles and function. For these targetted experiments, our focus,will be on cell types that show the greatest changes with age and/or are most critical for immune responsiveness; and from volunteers selected based on their genetic and epidemiological exposure profiles. Studies will be facilitated by complementary expertise of the participating centres, capitalising on unique bioresources. Overall, the advances in knowledge should better elucidate pathways of immunosenescence, reveal new biomarkers for early diagnosis of immune dysfunction, and point to target cells and molecules that can be supplemented or activated for eventual prevention or alleviation of ageing-related immune dysfunction.

 Deliverables

List of deliverables.
Website development and management Websites, patent fillings, videos etc. 2019-12-17 15:18:18

Take a look to the deliverables list in detail:  detailed list of ImmunoAgeing deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Andreas Meryk, Luca Pangrazzi, Magdalena Hagen, Florian Hatzmann, Brigitte Jenewein, Bojana Jakic, Natascha Hermann-Kleiter, Gottfried Baier, Juulia Jylhävä, Mikko Hurme, Klemens Trieb, Beatrix Grubeck-Loebenstein
Fcμ receptor as a Costimulatory Molecule for T Cells
published pages: 2681-2691.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.02.024
Cell Reports 26/10 2019-12-17
2018 Stella Lukas Yani, Michael Keller, Franz Leonard Melzer, Birgit Weinberger, Luca Pangrazzi, Sieghart Sopper, Klemens Trieb, Monia Lobina, Valeria Orrù, Edoardo Fiorillo, Francesco Cucca, Beatrix Grubeck-Loebenstein
CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01201
Frontiers in Immunology 9 2019-12-17
2017 Maristella Steri, Valeria Orrù, M. Laura Idda, Maristella Pitzalis, Mauro Pala, Ilenia Zara, Carlo Sidore, Valeria Faà, Matteo Floris, Manila Deiana, Isadora Asunis, Eleonora Porcu, Antonella Mulas, Maria G. Piras, Monia Lobina, Sandra Lai, Mara Marongiu, Valentina Serra, Michele Marongiu, Gabriella Sole, Fabio Busonero, Andrea Maschio, Roberto Cusano, Gianmauro Cuccuru, Francesca Deidda, Fausto Poddie, Gabriele Farina, Mariano Dei, Francesca Virdis, Stefania Olla, Maria A. Satta, Mario Pani, Alessandro Delitala, Eleonora Cocco, Jessica Frau, Giancarlo Coghe, Lorena Lorefice, Giuseppe Fenu, Paola Ferrigno, Maria Ban, Nadia Barizzone, Maurizio Leone, Franca R. Guerini, Matteo Piga, Davide Firinu, Ingrid Kockum, Izaura Lima Bomfim, Tomas Olsson, Lars Alfredsson, Ana Suarez, Patricia E. Carreira, Maria J. Castillo-Palma, Joseph H. Marcus, Mauro Congia, Andrea Angius, Maurizio Melis, Antonio Gonzalez, Marta E. Alarcón Riquelme, Berta M. da Silva, Maurizio Marchini, Maria G. Danieli, Stefano Del Giacco, Alessandro Mathieu, Antonello Pani, Stephen B. Montgomery, Giulio Rosati, Jan Hillert, Stephen Sawcer, Sandra D’Alfonso, John A. Todd, John Novembre, Gonçalo R. Abecasis, Michael B. Whalen, Maria G. Marrosu, Alessandra Meloni, Serena Sanna, Myriam Gorospe, David Schlessinger, Edoardo Fiorillo, Magdalena Zoledziewska, Francesco Cucca
Overexpression of the Cytokine BAFF and Autoimmunity Risk
published pages: 1615-1626, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1610528
New England Journal of Medicine 376/17 2019-12-17
2017 Luca Pangrazzi, Erin Naismith, Andreas Meryk, Michael Keller, Brigitte Jenewein, Klemens Trieb, Beatrix Grubeck-Loebenstein
Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus
published pages: 715, ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00715
Frontiers in Immunology 8 2019-12-17

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The information about "IMMUNOAGEING" are provided by the European Opendata Portal: CORDIS opendata.

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