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I-MOVE-plus SIGNED

I-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly

Total Cost €

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EC-Contrib. €

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Partnership

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Project "I-MOVE-plus" data sheet

The following table provides information about the project.

Coordinator
EPICONCEPT 

Organization address
address: RUE DE CHARENTON 47
city: PARIS
postcode: 75012
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://sites.google.com/a/epiconcept.fr/imoveplus/
 Total cost 7˙520˙005 €
 EC max contribution 7˙482˙728 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EPICONCEPT FR (PARIS) coordinator 1˙647˙873.00
2    Department of Health UK (Leeds) participant 587˙308.00
3    RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU NL (BILTHOVEN) participant 519˙507.00
4    STATENS SERUM INSTITUT DK (KOBENHAVN S) participant 510˙490.00
5    TERVEYDEN JA HYVINVOINNIN LAITOS FI (HELSINKI) participant 448˙650.00
6    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 392˙500.00
7    INSTITUTO NACIONAL DE SAUDE DR. RICARDO JORGE PT (LISBOA) participant 350˙158.00
8    HEALTH SERVICE EXECUTIVE HSE IE (NAAS) participant 325˙015.00
9    INSTITUTO DE SALUD CARLOS III ES (MADRID) participant 324˙588.00
10    INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA CANTACUZINO RO (BUCURESTI) participant 248˙625.00
11    NARODOWY INSTYTUT ZDROWIA PUBLICZNEGO-PANSTWOWY ZAKLAD HIGIENY PL (WARSZAWA) participant 242˙500.00
12    ORGANISMO AUTONOMO INSTITUTO DE SALUD PUBLICA Y LABORAL DE NAVARRA ES (PAMPLONA) participant 236˙250.00
13    HRVATSKI ZAVOD ZA JAVNO ZDRAVSTVO HR (ZAGREB) participant 217˙500.00
14    ROBERT KOCH-INSTITUT DE (Berlin) participant 182˙515.00
15    NHS NATIONAL SERVICES SCOTLAND UK (EDINBURGH) participant 182˙335.00
16    STICHTING NEDERLANDS INSTITUUT VOOR ONDERZOEK VAN DE GEZONDHEIDSZORG NL (UTRECHT) participant 173˙007.00
17    THE ROYAL COLLEGE OF GENERAL PRACTITIONERS UK (LONDON) participant 162˙506.00
18    SORBONNE UNIVERSITE FR (PARIS) participant 142˙500.00
19    ORSZAGOS TISZTIFOORVOSI HIVATAL HU (BUDAPEST) participant 139˙841.00
20    FOLKEHELSEINSTITUTTET NO (OSLO) participant 120˙343.00
21    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 90˙000.00
22    HOSPICES CIVILS DE LYON FR (LYON) participant 80˙722.00
23    CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER FR (MONTPELLIER) participant 60˙000.00
24    LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS LT (KAUNAS) participant 50˙000.00
25    CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES FR (RENNES CEDEX 9) participant 25˙000.00
26    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 18˙931.00
27    EMBERI EROFORRASOK MINISZTERIUMA HU (BUDAPEST) participant 4˙058.00
28    AGENCE NATIONALE DE SANTE PUBLIQUE FR (SAINT MAURICE) participant 0.00
29    INSTITUT DE VEILLE SANITAIRE FR (SAINT MAURICE CEDEX) participant 0.00
30    UNIVERSITE DE CORSE PASCAL PAOLI FR (CORTE) participant 0.00
31    UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 FR (PARIS) participant 0.00

Map

 Project objective

The I-MOVE Consortium includes European Union (EU) Public Health Institutes, SME and Universities. It aims at measuring and comparing the effectiveness (VE) and impact (VI) of influenza and Pneumococcal vaccines and vaccination strategies a in the elderly population in Europe. The goal is to develop a sustainable platform of primary care practices, hospitals and laboratory networks that share validated methods to evaluate post marketing vaccine performances. The objectives are to identify, pilot test, and disseminate in EU the best study designs to measure, on a real time basis, VE (direct effect) and the VI of vaccination programmes (indirect and overall effect) against laboratory confirmed cases of influenza (types/subtypes) and pneumococcal disease (serotypes), and clinical outcomes. Cost effectiveness analysis will be conducted.

Results will allow to understand factors affecting specific VE, the duration of protection of influenza and pneumococcal vaccines, the interaction between vaccines, the role of repeated vaccinations, the occurrence of serotype replacement (pneumococcus); identify vaccine types and brands with low VE; guide the decision of the WHO committees on vaccine strain selection (influenza); provide robust benefit indicators (VE and VI) and cost benefit and effectiveness results; guide vaccination strategies (schedules, doses, boosters). This EU member state collaboration will respond to questions that require studies based on large sample sizes and sharing of expertise that cannot be achieved by one country alone. It will allow the best methods to be used and results to benefit to all EU countries whatever their current public health achievements. Results will be shared with international partners.

 Deliverables

List of deliverables.
Third End of season, pooled influenza vaccine effectiveness estimates report. Documents, reports 2020-02-20 17:22:44
Scientific communication Documents, reports 2020-02-20 17:22:44
Submission of article summarising the I-MOVE+ experience in evaluating the influenza vaccines, results and perspective for the future. Documents, reports 2020-02-20 17:22:44
Third Report I-MOVE+ ST/Scientific Meetings Documents, reports 2020-02-20 17:22:45
Scientific manuscript WP4 Documents, reports 2020-02-20 17:22:44
Scientific Manuscript WP5 Documents, reports 2020-02-20 17:22:45
Third Study sites protocols and clearance from Ethical Committee to measure influenza vaccine effectiveness. Documents, reports 2020-02-20 17:22:44
Training material available. Documents, reports 2020-02-20 17:22:44
Report on influenza vaccine effectiveness and role of influenza on IPD and/or CAP incidence Documents, reports 2020-02-20 17:22:44
Third Scientific communication: one article submitted or results from I-MOVE+ influenza vaccines presented in an International Scientific Conference. Documents, reports 2020-02-20 17:22:44
One manuscript submitted for publication and/or abstracts for at least one conference. Documents, reports 2020-02-20 17:22:44
First End of season, pooled influenza vaccine effectiveness estimates report. Documents, reports 2020-02-20 17:22:41
Report with description of influenza and pneumococcal outcomes in each database. Documents, reports 2020-02-20 17:22:42
First Scientific communication: one article submitted or results from I-MOVE+ influenza vaccines presented in an International Scientific Conference. Documents, reports 2020-02-20 17:22:41
Second Scientific communication: one article submitted or results from I-MOVE+ influenza vaccines presented in an International Scientific Conference. Documents, reports 2020-02-20 17:22:41
Generic protocols for effectiveness and impact studies of pneumococcal vaccines Documents, reports 2020-02-20 17:22:41
First Study sites protocols and clearance from Ethical Committee to measure influenza vaccine effectiveness. Documents, reports 2020-02-20 17:22:42
Second Study sites protocols and clearance from Ethical Committee to measure influenza vaccine effectiveness. Documents, reports 2020-02-20 17:22:42
First Report I-Move+ ST/Scientific Meetings Documents, reports 2020-02-20 17:22:41
Second. Study sites protocols and clearance from Ethical Committee to measure influenza vaccine effectiveness. Documents, reports 2020-02-20 17:22:41
Written report including a generic cost-effectiveness model Documents, reports 2020-02-20 17:22:44
Third. Study sites protocols and clearance from Ethical Committee to measure influenza vaccine effectiveness. Documents, reports 2020-02-20 17:22:42
Generic protocols to measure influenza vaccine effectiveness at primary care and hospital level, using a test-negative design and screening method. Documents, reports 2020-02-20 17:22:43
I-MOVE+ website with different access level and tools for internal collaboration, communication Websites, patent fillings, videos etc. 2020-02-20 17:22:41
Second Study sites protocols to measure influenza vaccine impact in season. Documents, reports 2020-02-20 17:22:41
Third Study sites protocols to measure influenza vaccine impact in season. Documents, reports 2020-02-20 17:22:41
Second Report I-MOVE+ ST/Scientific Meetings Documents, reports 2020-02-20 17:22:41
Second End of season, pooled influenza vaccine effectiveness estimates report. Documents, reports 2020-02-20 17:22:41
First season Study sites protocols and clearance from Ethical Committee to measure influenza vaccine effectiveness. Documents, reports 2020-02-20 17:22:40
First season Study sites protocols to measure influenza vaccine impact in season. Documents, reports 2020-02-20 17:22:40
Generic protocol to measure impact of the seasonal influenza vaccine Documents, reports 2020-02-20 17:22:40

Take a look to the deliverables list in detail:  detailed list of I-MOVE-plus deliverables.

 Publications

year authors and title journal last update
List of publications.
2016 Hanne Dorthe Emborg, Tyra Grove Krause, Lene Nielsen, Marianne Kragh Thomsen, Claus Bohn Christiansen, Marianne Nielsine Skov, Xiaohui Chen Nielsen, Lenette Sandborg Weinreich, Thea Kølsen Fischer, Jesper Rønn, Ramona Trebbien
Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 – a rapid epidemiological and virological assessment
published pages: , ISSN: 1025-496X, DOI: 10.2807/1560-7917.ES.2016.21.14.30189
Eurosurveillance 21/14 2020-02-20
2017 Dominic Thorrington, Edwin van Leeuwen, Mary Ramsay, Richard Pebody, Marc Baguelin
Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in England
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0932-3
BMC Medicine 15/1 2020-02-20
2017 Maria-Pia Hergens, Ulrike Baum, Mia Brytting, Niina Ikonen, Anu Haveri, Åsa Wiman, Hanna Nohynek, Åke Örtqvist
Mid-season real-time estimates of seasonal influenza vaccine effectiveness in persons 65 years and older in register-based surveillance, Stockholm County, Sweden, and Finland, January 2017
published pages: , ISSN: 1025-496X, DOI: 10.2807/1560-7917.ES.2017.22.8.30469
Eurosurveillance 22/8 2020-02-20
2017 Jim Mc Menamin
Success of vaccination programmes is based on citizen´s trus in safety of vaccines
published pages: , ISSN: , DOI:
The Parliament Magazine 2020-02-20
2017 Marc Rondy, Odile Launay, Jesus Castilla, Simona Costanzo, Joan Puig-Barberà, Giedre Gefenaite, Amparo Larrauri, Caterina Rizzo, Daniela Pitigoi, Ritva K. Syrjänen, Ausenda Machado, Sanja Kurečić Filipović, Judit Krisztina Horváth, Iwona Paradowska-Stankiewicz, Sierk Marbus, Alain Moren
Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza
published pages: 4298-4306, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2017.06.088
Vaccine 35/34 2020-02-20
2017 Iván Martínez-Baz, Itziar Casado, Ana Navascués, Jorge Díaz-González, Aitziber Aguinaga, Laura Barrado, Josu Delfrade, Carmen Ezpeleta, Jesús Castilla
Effect of Repeated Vaccination With the Same Vaccine Component Against 2009 Pandemic Influenza A(H1N1) Virus
published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jix055
The Journal of Infectious Diseases 2020-02-20
2017 A.M. Vilcu, C. Souty, V. Enouf, L. Capai, C. Turbelin, S. Masse, S. Behillil, M. Valette, C. Guerrisi, L. Rossignol, T. Blanchon, B. Lina, T. Hanslik, A. Falchi
Estimation of seasonal influenza vaccine effectiveness using data collected in primary care in France: comparison of the test-negative design and the screening method
published pages: , ISSN: 1198-743X, DOI: 10.1016/j.cmi.2017.09.003
Clinical Microbiology and Infection 2020-02-20
2017 Alin Gherasim, Iván Martínez-Baz, Jesús Castilla, Francisco Pozo, Amparo Larrauri
Effect of previous and current vaccination against influenza A(H1N1)pdm09, A(H3N2), and B during the post-pandemic period 2010-2016 in Spain
published pages: e0179160, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0179160
PLOS ONE 12/6 2020-02-20
2017 Marc Rondy, Amparo Larrauri, Itziar Casado, Valeria Alfonsi, Daniela Pitigoi, Odile Launay, Ritva K Syrjänen, Giedre Gefenaite, Ausenda Machado, Vesna Višekruna Vučina, Judith Krisztina Horváth, Iwona Paradowska-Stankiewicz, Sierk D Marbus, Alin Gherasim, Jorge Alberto Díaz-González, Caterina Rizzo, Alina E Ivanciuc, Florence Galtier, Niina Ikonen, Aukse Mickiene, Veronica Gomez, Sanja Kurečić Filipović, Annamária Ferenczi, Monika R Korcinska, Rianne van Gageldonk-Lafeber, Marta Valenciano
2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
published pages: , ISSN: 1025-496X, DOI: 10.2807/1560-7917.ES.2017.22.30.30580
Eurosurveillance 22/30 2020-02-20
2017 Cécile Souty, Ana-Maria Vilcu, Lisandru Capai, Sylvie van der Werf, Martine Valette, Thierry Blanchon, Bruno Lina, Sylvie Behillil, Thomas Hanslik, Alessandra Falchi
Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France
published pages: 1-4, ISSN: 1386-6532, DOI: 10.1016/j.jcv.2017.08.002
Journal of Clinical Virology 95 2020-02-20
2016 Gómez, Verónica; Guiomar, Raquel; Rodrigues, Ana Paula; Pechirra, Pedro; Conde, Patrícia; Cristóvão, Paula; Costa, Inês; Nunes, Baltazar; Machado, Ausenda
Influenza vaccine effectiveness in Portugal: season 2015/2016 report
published pages: , ISSN: , DOI:
2 2020-02-20
2016 Richard Pebody, Fiona Warburton, Joanna Ellis, Nick Andrews, Alison Potts, Simon Cottrell, Jillian Johnston, Arlene Reynolds, Rory Gunson, Catherine Thompson, Monica Galiano, Chris Robertson, David Mullett, Naomh Gallagher, Mary Sinnathamby, Ivelina Yonova, Catherine Moore, Jim McMenamin, Simon de Lusignan, Maria Zambon
Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results
published pages: , ISSN: 1025-496X, DOI: 10.2807/1560-7917.ES.2016.21.13.30179
Eurosurveillance 21/13 2020-02-20
2016 Rodrigues, Ana Paula; Pechirra, Pedro; Guiomar, Raquel; Conde, Patrícia; Gomez, Verónica; Nunes, Baltazar; Machado, Ausenda
Virological data integration on influenza vaccine effectiveness, Portugal 2015/16
published pages: , ISSN: , DOI:
1 2020-02-20
2017 Esther Kissling, Marc Rondy
Early 2016/17 vaccine effectiveness estimates against influenza A(H3N2): I-MOVE multicentre case control studies at primary care and hospital levels in Europe
published pages: , ISSN: 1025-496X, DOI: 10.2807/1560-7917.ES.2017.22.7.30464
Eurosurveillance 22/7 2020-02-20
2016 Jim McMenamin
Vaccine performance needs careful and independent evaluation
published pages: , ISSN: , DOI:
The Parliament Magazine Issue 432/18 April 2016 2020-02-20
2017 Jesús Castilla, Ana Navascués, Itziar Casado, Jorge Díaz-González, Alejandra Pérez-García, Leticia Fernandino, Iván Martínez-Baz, Aitziber Aguinaga, Francisco Pozo, Carmen Ezpeleta
Combined effectiveness of prior and current season influenza vaccination in northern Spain: 2016/17 mid-season analysis
published pages: , ISSN: 1025-496X, DOI: 10.2807/1560-7917.ES.2017.22.7.30465
Eurosurveillance 22/7 2020-02-20
2018 Dominic Thorrington, Leo van Rossum, Mirjam Knol, Hester de Melker, Hans Rümke, Eelko Hak, Albert Jan van Hoek
Impact and cost-effectiveness of different vaccination strategies to reduce the burden of pneumococcal disease among elderly in the Netherlands
published pages: e0192640, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0192640
PLOS ONE 13/2 2020-02-20
2019 Irina Kislaya, Ana Paula Rodrigues, Mafalda Sousa-Uva, Verónica Gómez, Paulo Gonçalves, Filipe Froes, Baltazar Nunes
Indirect effect of 7-valent and 13-valent pneumococcal conjugated vaccines on pneumococcal pneumonia hospitalizations in elderly
published pages: e0209428, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0209428
PLOS ONE 14/1 2020-02-20
2017 Marc Rondy, Alin Gherasim, Itziar Casado, Odile Launay, Caterina Rizzo, Daniela Pitigoi, Aukse Mickiene, Sierk D Marbus, Ausenda Machado, Ritva K Syrjänen, Iva Pem-Novose, Judith Krisztina Horváth, Amparo Larrauri, Jesús Castilla, Philippe Vanhems, Valeria Alfonsi, Alina E Ivanciuc, Monika Kuliese, Rianne van Gageldonk-Lafeber, Veronica Gomez, Niina Ikonen, Zvjezdana Lovric, Annamária Ferenczi, Alain Moren
Low 2016/17 season vaccine effectiveness against hospitalised influenza A(H3N2) among elderly: awareness warranted for 2017/18 season
published pages: , ISSN: 1560-7917, DOI: 10.2807/1560-7917.ES.2017.22.41.17-00645
Eurosurveillance 22/41 2020-02-20
2018 Marc Rondy, Esther Kissling, Hanne-Dorthe Emborg, Alin Gherasim, Richard Pebody, Ramona Trebbien, Francisco Pozo, Amparo Larrauri, Jim McMenamin, Marta Valenciano
Interim 2017/18 influenza seasonal vaccine effectiveness: combined results from five European studies
published pages: , ISSN: 1560-7917, DOI: 10.2807/1560-7917.ES.2018.23.9.18-00086
Eurosurveillance 23/9 2020-02-20
2018 Jesús Castilla, Ana Navascués, Itziar Casado, Alejandra Pérez-García, Aitziber Aguinaga, Guillermo Ezpeleta, Francisco Pozo, Carmen Ezpeleta, Iván Martínez-Baz
Interim effectiveness of trivalent influenza vaccine in a season dominated by lineage mismatched influenza B, northern Spain, 2017/18
published pages: , ISSN: 1560-7917, DOI: 10.2807/1560-7917.es.2018.23.7.18-00057
Eurosurveillance 23/7 2020-02-20
2018 Itziar Casado, Ángela Domínguez, Diana Toledo, Judith Chamorro, Jenaro Astray, Mikel Egurrola, María Amelia Fernández-Sierra, Vicente Martín, María Morales-Suárez-Varela, Pere Godoy, Jesús Castilla
Repeated influenza vaccination for preventing severe and fatal influenza infection in older adults: a multicentre case–control study
published pages: E3-E12, ISSN: 0820-3946, DOI: 10.1503/cmaj.170910
Canadian Medical Association Journal 190/1 2020-02-20
2018 Germaine Hanquet, Pavla Krizova, Palle Valentiner-Branth, Shamez N Ladhani, J Pekka Nuorti, Agnes Lepoutre, Jolita Mereckiene, Mirjam Knol, Brita A Winje, Pilar Ciruela, Maria Ordobas, Marcela Guevara, Eisin McDonald, Eva Morfeldt, Jana Kozakova, Hans-Christian Slotved, Norman K Fry, Hanna Rinta-Kokko, Emmanuelle Varon, Mary Corcoran, Arie van der Ende, Didrik F Vestrheim, Carmen Munoz-Almagro, Pello Latasa, Jesus Castilla, Andrew Smith, Birgitta Henriques-Normark, Robert Whittaker, Lucia Pastore Celentano, Camelia Savulescu
Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination
published pages: thoraxjnl-2018-2, ISSN: 0040-6376, DOI: 10.1136/thoraxjnl-2018-211767
Thorax 2020-02-20
2018 Richard G Pebody, Mary A Sinnathamby, Fiona Warburton, Nick Andrews, Nicola L Boddington, Hongxin Zhao, Ivelina Yonova, Joanna Ellis, Elise Tessier, Matthew Donati, Alex J Elliot, Helen E Hughes, Sameera Pathirannehelage, Rachel Byford, Gillian E Smith, Simon de Lusignan, Maria Zambon
Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16
published pages: , ISSN: 1560-7917, DOI: 10.2807/1560-7917.es.2018.23.25.1700496
Eurosurveillance 23/25 2020-02-20
2018 Adam Meijer, Corien M Swaan, Martin Voerknecht, Edin Jusic, Sharon van den Brink, Lisa A Wijsman, Bettie CG Voordouw, Gé A Donker, Jacqueline Sleven, Wendelien W Dorigo-Zetsma, Sanela Svraka, Michiel van Boven, Manon R Haverkate, Aura Timen, Jaap T van Dissel, Marion PG Koopmans, Theo M Bestebroer, Ron AM Fouchier
Case of seasonal reassortant A(H1N2) influenza virus infection, the Netherlands, March 2018
published pages: , ISSN: 1560-7917, DOI: 10.2807/1560-7917.es.2018.23.15.18-00160
Eurosurveillance 23/15 2020-02-20

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