Explore the words cloud of the PRECIOUS project. It provides you a very rough idea of what is the project "PRECIOUS" about.
The following table provides information about the project.
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
|Coordinator Country||Netherlands [NL]|
|Total cost||5˙994˙000 €|
|EC max contribution||5˙994˙000 € (100%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2015-06-01 to 2020-05-31|
Take a look of project's partnership.
|1||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||coordinator||1˙592˙763.00|
|2||ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK||FR (PARIS)||participant||539˙595.00|
|3||OSLO UNIVERSITETSSYKEHUS HF||NO (OSLO)||participant||476˙625.00|
|4||CTC NORTH GMBH & CO KG||DE (HAMBURG)||participant||384˙400.00|
|5||UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF||DE (HAMBURG)||participant||372˙250.00|
|6||THE UNIVERSITY OF EDINBURGH||UK (EDINBURGH)||participant||362˙653.00|
|7||ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||participant||323˙165.00|
|9||UNIVERSITY OF GLASGOW||UK (GLASGOW)||participant||263˙726.00|
|10||DEBRECENI EGYETEM||HU (DEBRECEN)||participant||257˙600.00|
|11||AZIENDA SOCIO SANITARIA TERRITORIALE DI MANTOVA(ASST DI MANTOVA)||IT (MANTOVA)||participant||250˙360.00|
|12||PANEPISTIMIO THESSALIAS||EL (VOLOS)||participant||236˙350.00|
|13||INSTYTUT PSYCHIATRII I NEUROLOGII||PL (WARSZAWA)||participant||230˙100.00|
|14||SIHTASUTUS TARTU ULIKOOLI KLIINIKUM||EE (TARTU)||participant||121˙725.00|
|15||THE UNIVERSITY OF NOTTINGHAM||UK (NOTTINGHAM)||participant||114˙597.00|
|16||GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG||DE (MUENCHEN)||participant||82˙016.00|
|17||STROKE ALLIANCE FOR EUROPE||BE (BRUSSELS)||participant||45˙025.00|
|18||ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM||NL (ROTTERDAM)||participant||23˙065.00|
|19||AZIENDA OSPEDALIERA CARLO POMA||IT (MANTUA)||participant||0.00|
Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occurrence in the elderly. The elderly have been strongly underrepresented in previous stroke trials and treatment guidelines have no recommendations specific to this important group. Elderly patients are at the highest risk of complications after stroke, such as infections, fever, and dysphagia. These complications are strongly and independently associated with a higher risk of death or dependency. We will perform a pragmatic, randomised, open clinical trial with blinded outcome assessment in 3800 patients with acute stroke aged 66 years or older, to assess whether pharmacological prevention of infections and fever, and early management of dysphagia, will reduce the risk of death, poor functional outcome, and poor quality of life, and lead to reductions in the costs of stroke care throughout Europe. Patients will be randomised using a factorial design to preventive treatment for 4 days with ceftriaxone, paracetamol, and/or metoclopramide, or to ‘standard care’ alone. The primary outcome is functional outcome at 3 months, assessed with the modified Rankin Scale (mRS), and analysed with ordinal logistic regression. The study will have 90% power to detect a statistically significant shift towards a favourable outcome, assuming a 5% absolute increase in the proportion of patients with a good outcome (mRS 0 to 2) in the intervention group, compared with controls. This simple, safe, and generally available treatment strategy has the potential to lead to an annual reduction of over 25 000 elderly Europeans being dead or dependent as a result of stroke, at very low costs.
|Initial dissemination report||Documents, reports||2020-01-24 09:03:58|
|Dissemination plan||Documents, reports||2020-01-24 09:03:58|
|Launch of website and social media accounts||Websites, patent fillings, videos etc.||2020-01-24 09:03:58|
Take a look to the deliverables list in detail: detailed list of PRECIOUS deliverables.
|year||authors and title||journal||last update|
Bart van der Worp, Bart van der Worp
Prevention of complications to Improve outcome in elderly patients with acute stroke - A randomised clinical trial
published pages: , ISSN: 2396-9881, DOI: 10.1186/ISRCTN82217627
|European Stroke Journal||2020-01-24|
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The information about "PRECIOUS" are provided by the European Opendata Portal: CORDIS opendata.
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