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Mechanistic and functional studies of Bacillus biofilms assembly on plants, and their impact in sustainable agriculture and food safety

Total Cost €


EC-Contrib. €






 BacBio project word cloud

Explore the words cloud of the BacBio project. It provides you a very rough idea of what is the project "BacBio" about.

vegetables    differential    proteins    biofilms    convey    interacts    combine    integral    genetics    sustainability    health    exploited    differentiation    subtilis    functional    developmental    extracellular    bacillus    purpose    amyloid    matrix    cereus    assembly    central    vast    conventional    impulse    criteria    minimizing    committed    components    am    biochemistry    safety    planning    bca    external    interaction    circuitries    multidisciplinary    axis    biocontrol    scenarios    govern    combat    biotechnological    parallel    productivity    questions    commercialized    exist    variable    plant    food    structural    agriculture    start    proteomics    sustainable    inhibit    ending    microorganisms    molecular    communicates    interconnected    applicability    trigger    biofilm    investigation    pathogen    antibiotic    exopolysaccharides    physiology    isolates    fitness    therapies    ecology    biology    plants    knowing    borne    visualize    diseases    cell    bacterial    agent    expression    bacterium    microbial    insights    population    conceived    bcas    pathogenic    beneficial    efficiency    combined   

Project "BacBio" data sheet

The following table provides information about the project.


Organization address
city: MALAGA
postcode: 29016

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙453˙562 €
 EC max contribution 1˙453˙562 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2021-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE MALAGA ES (MALAGA) coordinator 1˙453˙562.00


 Project objective

Sustainable agriculture is an ambitious concept conceived to improve productivity but minimizing side effects. Why the efficiency of a biocontrol agent is so variable? How can different therapies be efficiently exploited in a combined way to combat microbial diseases? These are questions that need investigation to convey with criteria of sustainability. What I present is an integral proposal aim to study the microbial ecology and specifically bacterial biofilms as a central axis of two differential but likely interconnected scenarios in plant health: i) the beneficial interaction of the biocontrol agent (BCA) Bacillus subtilis, and ii) the non-conventional interaction of the food-borne pathogen Bacillus cereus. I will start working with B. subtilis, and reasons are: 1) Different isolates are promising BCAs and are commercialized for such purpose, 2) There exist vast information of the genetics circuitries that govern important aspects of B. subtilis physiology as antibiotic production, cell differentiation, and biofilm formation. In parallel I propose to study the way B. cereus, a food-borne pathogenic bacterium interacts with vegetables. I am planning to set up a multidisciplinary approach that will combine genetics, biochemistry, proteomics, cell biology and molecular biology to visualize how these bacterial population interacts, communicates with plants and other microorganisms, or how all these factors trigger or inhibit the developmental program ending in biofilm formation. I am also interested on knowing if structural components of the bacterial extracellular matrix (exopolysaccharides or amyloid proteins) are important for bacterial fitness. If this were the case, I will also investigate which external factors affect their expression and assembly in functional biofilms. The insights get on these studies are committed to impulse our knowledge on microbial ecology and their biotechnological applicability to sustainable agriculture and food safety.


year authors and title journal last update
List of publications.
2018 Antoine Loquet, Sven J. Saupe, Diego Romero
Functional Amyloids in Health and Disease
published pages: 3629-3630, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.07.024
Journal of Molecular Biology 430/20 2019-11-07
2018 Jesús Cámara-Almirón, Joaquin Caro-Astorga, Antonio de Vicente, Diego Romero
Beyond the expected: the structural and functional diversity of bacterial amyloids
published pages: 653-666, ISSN: 1040-841X, DOI: 10.1080/1040841x.2018.1491527
Critical Reviews in Microbiology 44/6 2019-11-07
2019 Carlos Molina-Santiago, John R. Pearson, Yurena Navarro, María Victoria Berlanga-Clavero, Andrés Mauricio Caraballo-Rodriguez, Daniel Petras, María Luisa García-Martín, Gaelle Lamon, Birgit Haberstein, Francisco M. Cazorla, Antonio de Vicente, Antoine Loquet, Pieter C. Dorrestein, Diego Romero
The extracellular matrix protects Bacillus subtilis colonies from Pseudomonas invasion and modulates plant co-colonization
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09944-x
Nature Communications 10/1 2019-11-07
2019 Nadia El Mammeri, Jesus Hierrezuelo, James Tolchard, Jesús Cámara-Almirón, Joaquín Caro-Astorga, Ana Álvarez-Mena, Antoine Dutour, Mélanie Berbon, Jayakrishna Shenoy, Estelle Morvan, Axelle Grélard, Brice Kauffmann, Sophie Lecomte, Antonio de Vicente, Birgit Habenstein, Diego Romero, Antoine Loquet
Molecular architecture of bacterial amyloids in Bacillus biofilms
published pages: fj.201900831R, ISSN: 0892-6638, DOI: 10.1096/fj.201900831r
The FASEB Journal 2019-11-07

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