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PANDORA SIGNED

Probing safety of nano-objects by defining immune responses of environmental organisms

Total Cost €

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EC-Contrib. €

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Partnership

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 PANDORA project word cloud

Explore the words cloud of the PANDORA project. It provides you a very rough idea of what is the project "PANDORA" about.

nanoparticles    representative    11    encompasses    determinant    conserved    expertise    organisms    invertebrates    cerium    industrially    nano    vertebrates    phd    bivalves    levels    networking    defence    infrastructures    joint    global    environment    scientific    cross    assays    mechanisms    nanosafety    iron    evolution    tackle    stages    public    skills    immune    markers    objects    marine    smes    education    students    species    np    echinoderms    triggered    vs    immunosafety    survival    exchange    terrestrial    evolutionary    fitness    pandora    titanium    inflammation    overarching    centres    hierarchical    events    immuno    environmental    academic    plants    train    immunological    transferrable    human    shared    predictive    innate    industrial    capacity    oxide    intense    probing    living    earthworms    arabidopsis    participation    engineered    courses    vitro    issue    invertebrate    immunity    stress    training    collaborative    health    vertebrate    intersectoral    proven    safety    risk    plan   

Project "PANDORA" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.pandora-h2020.eu/
 Total cost 2˙814˙491 €
 EC max contribution 2˙814˙491 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 516˙122.00
2    AvantiCell Science Ltd UK (AYR) participant 273˙287.00
3    CARDIFF UNIVERSITY UK (CARDIFF) participant 273˙287.00
4    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) participant 258˙061.00
5    PARIS-LODRON-UNIVERSITAT SALZBURG AT (SALZBURG) participant 255˙934.00
6    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 249˙216.00
7    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) participant 247˙872.00
8    UNIVERZA V LJUBLJANI SI (LJUBLJANA) participant 234˙997.00
9    MIKROBIOLOGICKY USTAV AV CR V.V.I CZ (PRAHA 4) participant 232˙422.00
10    UK CENTRE FOR ECOLOGY & HYDROLOGY UK (Oxford) participant 159˙417.00
11    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) participant 113˙869.00
12    NATURAL ENVIRONMENT RESEARCH COUNCIL UK (SWINDON WILTSHIRE) participant 0.00
13    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU IT (SIENA) partner 0.00

Map

 Project objective

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g., iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species. PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing. PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.

 Deliverables

List of deliverables.
Website Websites, patent fillings, videos etc. 2020-03-17 11:54:36
Individual CDP Documents, reports 2020-03-17 11:54:36
Dissemination Documents, reports 2020-03-17 11:54:36
Recruitment Documents, reports 2020-03-17 11:54:36
Scientific meetings Other 2020-03-17 11:54:36
Secondments Documents, reports 2020-03-17 11:54:36
SCT activities Documents, reports 2020-03-17 11:54:36
SSC activities Documents, reports 2020-03-17 11:54:36
Local training Documents, reports 2020-03-17 11:54:36
Industrial outreach Documents, reports 2020-03-17 11:54:36

Take a look to the deliverables list in detail:  detailed list of PANDORA deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Andi Alijagic, Daniela Gaglio, Elisabetta Napodano, Roberta Russo, Caterina Costa, Oldřich Benada, Olga Kofroňová, Annalisa Pinsino
Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity
published pages: 121389, ISSN: 0304-3894, DOI: 10.1016/j.jhazmat.2019.121389
Journal of Hazardous Materials 384 2020-03-17
2020 P. Prochazkova, R. Roubalova, J. Dvorak, N.I. Navarro Pacheco, M. Bilej
Pattern recognition receptors in annelids
published pages: 103493, ISSN: 0145-305X, DOI: 10.1016/j.dci.2019.103493
Developmental & Comparative Immunology 102 2020-03-17
2018 Sara Michelini, Muamera Sarajlic, Albert Duschl, Jutta Horejs-Hoeck
IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells
published pages: 610-615, ISSN: 0198-8859, DOI: 10.1016/j.humimm.2018.06.002
Human Immunology 79/8 2020-03-17
2019 A. Pinsino, and A. Alijagic
First person – Annalisa Pinsino and Andi Alijagic
published pages: bio042242, ISSN: 2046-6390, DOI: 10.1242/bio.042242
Biology Open 8/3 2020-03-17
2019 Silvia Franzellitti, Laura Canesi, Manon Auguste, Rajapaksha H.G.R. Wathsala, Elena Fabbri
Microplastic exposure and effects in aquatic organisms: A physiological perspective
published pages: 37-51, ISSN: 1382-6689, DOI: 10.1016/j.etap.2019.03.009
Environmental Toxicology and Pharmacology 68 2020-03-17
2019 Manon Auguste, Aide Lasa, Alberto Pallavicini, Stefano Gualdi, Luigi Vezzulli, Laura Canesi
Exposure to TiO2 nanoparticles induces shifts in the microbiota composition of Mytilus galloprovincialis hemolymph
published pages: 129-137, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2019.03.133
Science of The Total Environment 670 2020-03-17
2018 M. Auguste, C. Ciacci, T. Balbi, A. Brunelli, V. Caratto, A. Marcomini, R. Cuppini, L. Canesi
Effects of nanosilver on Mytilus galloprovincialis hemocytes and early embryo development
published pages: 107-116, ISSN: 0166-445X, DOI: 10.1016/j.aquatox.2018.08.005
Aquatic Toxicology 203 2020-03-17
2019 Andi Alijagic, Oldřich Benada, Olga Kofroňová, Diego Cigna, Annalisa Pinsino
Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02261
Frontiers in Immunology 10 2020-03-17
2019 Petra Prochazkova, Radka Roubalova, Frantisek Skanta, Jiri Dvorak, Natividad Isabel Navarro Pacheco, Miroslav Kolarik, Martin Bilej
Developmental and Immune Role of a Novel Multiple Cysteine Cluster TLR From Eisenia andrei Earthworms
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01277
Frontiers in Immunology 10 2020-03-17
2019 M. Auguste, T. Balbi, M. Montagna, R. Fabbri, M. Sendra, J. Blasco, L. Canesi
In vivo immunomodulatory and antioxidant properties of nanoceria (nCeO2) in the marine mussel Mytilus galloprovincialis
published pages: 95-102, ISSN: 1532-0456, DOI: 10.1016/j.cbpc.2019.02.006
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 219 2020-03-17
2019 Annalisa Pinsino, Andi Alijagic
Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions
published pages: bio039289, ISSN: 2046-6390, DOI: 10.1242/bio.039289
Biology Open 8/3 2020-03-17
2018 Diana Boraschi, Benjamin J. Swartzwelter, Paola Italiani
Interaction of engineered nanomaterials with the immune system: Health-related safety and possible benefits
published pages: 74-83, ISSN: 2468-2020, DOI: 10.1016/j.cotox.2018.02.002
Current Opinion in Toxicology 10 2020-03-17

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