Explore the words cloud of the CoordinatedDopamine project. It provides you a very rough idea of what is the project "CoordinatedDopamine" about.
The following table provides information about the project.
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
|Coordinator Country||Netherlands [NL]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-05-01 to 2020-04-30|
Take a look of project's partnership.
|1||ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||coordinator||812˙500.00|
|2||KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW||NL (AMSTERDAM)||participant||687˙500.00|
The basal ganglia consist of a set of neuroanatomical structures that participate in the representation and execution of action sequences. Dopamine neurotransmission in the striatum, the main input nucleus of the basal ganglia, is a fundamental mechanism involved in learning and regulation of such actions. The striatum has multiple functional units, where the limbic striatum is thought to mediate motivational aspects of actions (e.g., goal-directedness) and the sensorimotor striatum their automation (e.g., habit formation). A long-standing question in the field is how limbic and sensorimotor domains communicate with each other, and specifically if they do so during the automation of action sequences. It has been suggested that such coordination is implemented by reciprocal loop connections between striatal projection neurons and the dopaminergic midbrain. Although very influential in theory the effectiveness of this limbic-sensorimotor “bridging” principle has yet to be verified. I hypothesize that during the automation of behaviour regional dopamine signalling is governed by a striatal hierarchy and that dysregulation of this coordination leads to compulsive execution of automatic actions characteristic of several psychiatric disorders. To test this hypothesis, we will conduct electrochemical measurements with real-time resolution simultaneously in limbic and sensorimotor striatum to assess the regional coordination of dopamine release in behaving animals. We developed novel chronically implantable electrodes to enable monitoring of dopamine dynamics throughout the development of habitual behaviour and its compulsive execution in transgenic rats - a species suitable for our complex behavioural assays. Novel rabies virus-mediated gene delivery for in vivo optogenetics in these rats will give us the unique opportunity to test whether specific loop pathways govern striatal dopamine transmission and are causally involved in habit formation and compulsive behaviour.
|year||authors and title||journal||last update|
Bastijn J.G. van den Boom, Pavlina Pavlidi, Casper J.H. Wolf, Adriana H. Mooij, Ingo Willuhn
Automated classification of self-grooming in mice using open-source software
published pages: 48-56, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2017.05.026
|Journal of Neuroscience Methods 289||2019-09-02|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COORDINATEDDOPAMINE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "COORDINATEDDOPAMINE" are provided by the European Opendata Portal: CORDIS opendata.
Mapping out the poetic landscape(s) of the Roman empire: Ethnic and regional variations, socio-cultural diversity, and cross-cultural transformationsRead More
Mediating the Future: The Social Dynamics of Public ProjectionsRead More
A DNA NANOtechology toolkit for artificial CELL designRead More