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CoordinatedDopamine SIGNED

Coordination of regional dopamine release in the striatum during habit formation and compulsive behaviour

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CoordinatedDopamine project word cloud

Explore the words cloud of the CoordinatedDopamine project. It provides you a very rough idea of what is the project "CoordinatedDopamine" about.

signalling    opportunity    release    assays    gene    psychiatric    functional    structures    question    striatal    governed    mediate    limbic    hypothesize    neuroanatomical    effectiveness    motivational    behavioural    electrodes    dopaminergic    habit    resolution    input    units    leads    neurons    give    representation    dysregulation    fundamental    virus    sensorimotor    time    thought    connections    neurotransmission    compulsive    nucleus    consist    automatic    verified    dynamics    communicate    reciprocal    projection    basal    behaving    suitable    species    vivo    animals    optogenetics    mechanism    transmission    causally    midbrain    action    bridging    directedness    monitoring    influential    habitual    domains    sequences    mediated    multiple    chronically    regulation    conduct    hierarchy    simultaneously    implantable    electrochemical    striatum    rats    participate    suggested    theory    ganglia    transgenic    govern    disorders    rabies    regional    loop    automation    learning    hypothesis    actions    dopamine   

Project "CoordinatedDopamine" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Netherlands [NL]
 Project website https://herseninstituut.nl/en/research/researchgroups/denyswilluhn-group/
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 812˙500.00
2    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) participant 687˙500.00

Map

 Project objective

The basal ganglia consist of a set of neuroanatomical structures that participate in the representation and execution of action sequences. Dopamine neurotransmission in the striatum, the main input nucleus of the basal ganglia, is a fundamental mechanism involved in learning and regulation of such actions. The striatum has multiple functional units, where the limbic striatum is thought to mediate motivational aspects of actions (e.g., goal-directedness) and the sensorimotor striatum their automation (e.g., habit formation). A long-standing question in the field is how limbic and sensorimotor domains communicate with each other, and specifically if they do so during the automation of action sequences. It has been suggested that such coordination is implemented by reciprocal loop connections between striatal projection neurons and the dopaminergic midbrain. Although very influential in theory the effectiveness of this limbic-sensorimotor “bridging” principle has yet to be verified. I hypothesize that during the automation of behaviour regional dopamine signalling is governed by a striatal hierarchy and that dysregulation of this coordination leads to compulsive execution of automatic actions characteristic of several psychiatric disorders. To test this hypothesis, we will conduct electrochemical measurements with real-time resolution simultaneously in limbic and sensorimotor striatum to assess the regional coordination of dopamine release in behaving animals. We developed novel chronically implantable electrodes to enable monitoring of dopamine dynamics throughout the development of habitual behaviour and its compulsive execution in transgenic rats - a species suitable for our complex behavioural assays. Novel rabies virus-mediated gene delivery for in vivo optogenetics in these rats will give us the unique opportunity to test whether specific loop pathways govern striatal dopamine transmission and are causally involved in habit formation and compulsive behaviour.

 Publications

year authors and title journal last update
List of publications.
2017 Bastijn J.G. van den Boom, Pavlina Pavlidi, Casper J.H. Wolf, Adriana H. Mooij, Ingo Willuhn
Automated classification of self-grooming in mice using open-source software
published pages: 48-56, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2017.05.026
Journal of Neuroscience Methods 289 2019-09-02

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