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CoordinatedDopamine SIGNED

Coordination of regional dopamine release in the striatum during habit formation and compulsive behaviour

Total Cost €

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EC-Contrib. €

0

Partnership

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 CoordinatedDopamine project word cloud

Explore the words cloud of the CoordinatedDopamine project. It provides you a very rough idea of what is the project "CoordinatedDopamine" about.

conduct    simultaneously    fundamental    behaving    automatic    representation    electrodes    input    learning    optogenetics    transgenic    mediated    consist    leads    monitoring    animals    bridging    rabies    multiple    actions    hypothesis    midbrain    striatal    transmission    electrochemical    give    behavioural    dysregulation    chronically    regulation    assays    automation    causally    species    psychiatric    dopaminergic    hierarchy    signalling    thought    hypothesize    virus    structures    connections    habit    loop    action    limbic    neurotransmission    units    participate    resolution    nucleus    verified    striatum    habitual    opportunity    dopamine    sensorimotor    projection    ganglia    release    theory    sequences    disorders    domains    implantable    neurons    neuroanatomical    effectiveness    mechanism    compulsive    directedness    dynamics    gene    reciprocal    mediate    regional    suitable    question    suggested    govern    communicate    motivational    governed    functional    vivo    influential    time    basal    rats   

Project "CoordinatedDopamine" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: MEIBERGDREEF 15
city: AMSTERDAM
postcode: 1105AZ
website: www.amc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Netherlands [NL]
 Project website https://herseninstituut.nl/en/research/researchgroups/denyswilluhn-group/
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 812˙500.00
2    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) participant 687˙500.00

Map

 Project objective

The basal ganglia consist of a set of neuroanatomical structures that participate in the representation and execution of action sequences. Dopamine neurotransmission in the striatum, the main input nucleus of the basal ganglia, is a fundamental mechanism involved in learning and regulation of such actions. The striatum has multiple functional units, where the limbic striatum is thought to mediate motivational aspects of actions (e.g., goal-directedness) and the sensorimotor striatum their automation (e.g., habit formation). A long-standing question in the field is how limbic and sensorimotor domains communicate with each other, and specifically if they do so during the automation of action sequences. It has been suggested that such coordination is implemented by reciprocal loop connections between striatal projection neurons and the dopaminergic midbrain. Although very influential in theory the effectiveness of this limbic-sensorimotor “bridging” principle has yet to be verified. I hypothesize that during the automation of behaviour regional dopamine signalling is governed by a striatal hierarchy and that dysregulation of this coordination leads to compulsive execution of automatic actions characteristic of several psychiatric disorders. To test this hypothesis, we will conduct electrochemical measurements with real-time resolution simultaneously in limbic and sensorimotor striatum to assess the regional coordination of dopamine release in behaving animals. We developed novel chronically implantable electrodes to enable monitoring of dopamine dynamics throughout the development of habitual behaviour and its compulsive execution in transgenic rats - a species suitable for our complex behavioural assays. Novel rabies virus-mediated gene delivery for in vivo optogenetics in these rats will give us the unique opportunity to test whether specific loop pathways govern striatal dopamine transmission and are causally involved in habit formation and compulsive behaviour.

 Publications

year authors and title journal last update
List of publications.
2017 Bastijn J.G. van den Boom, Pavlina Pavlidi, Casper J.H. Wolf, Adriana H. Mooij, Ingo Willuhn
Automated classification of self-grooming in mice using open-source software
published pages: 48-56, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2017.05.026
Journal of Neuroscience Methods 289 2019-09-02

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