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Weakinteract SIGNED

Weak interactions in self-organizations studied by NMR spectroscopy in the supramolecular solid-state

Total Cost €

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EC-Contrib. €

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Partnership

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 Weakinteract project word cloud

Explore the words cloud of the Weakinteract project. It provides you a very rough idea of what is the project "Weakinteract" about.

delivering    resolution    potentiality    labeling    biophysicists    structures    spectroscopy    living    chemists    structural    heterogeneous    tackle    time    solution    assemblies    subunits    protein    tremendous    usually    templating    fail    form    filaments    insoluble    drug    isotope    self    partial    solubility    initiation    preventing    longstanding    understand    consequence    investigation    individual    ultimately    architectures    context    inspired    proof    elucidate    nanotubes    basis    material    biologists    scaffolding    atomic    revealing    exhibiting    hybrid    found    entities    physical    mechanisms    interfaces    synthetic    materials    phenomenon    hydrogel    chemistry    ray    fold    organize    solid    assembly    nmr    assembled    soft    weak    complexity    fundamental    lacking    cells    amyloid    crystalline    standard    supramolecular    integration    electronic    engineer    ordered    interactions    strategic    bacterial    elaboration    weakinteract    poor    techniques    crystallography    structure   

Project "Weakinteract" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.loquetlab.org/erc-project/
 Total cost 1˙472˙425 €
 EC max contribution 1˙472˙425 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙472˙425.00

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 Project objective

Self-assembly is a fundamental process by which individual subunits organize into ordered supramolecular entities, usually through weak interactions. A longstanding goal is to engineer synthetic self-organized structures, often inspired by protein assemblies found in the context of living cells, to design materials of high potentiality, e.g. drug delivery, scaffolding or electronic applications. There is a tremendous interest in physical chemistry to understand the role of weak interactions at the supramolecular interfaces. However, self-organizations usually form soft material, lacking crystalline order and at the same time exhibiting poor solubility. As a consequence, standard techniques for structural investigation such as X-ray crystallography or solution NMR usually fail or deliver only partial information, preventing an atomic-level understanding and therefore the design of new architectures. The Weakinteract project aims at developing NMR spectroscopy in the relevant supramolecular solid-state for those non-crystalline and insoluble self-organizations. Weakinteract will exploit strategic isotope labeling, state-of-the-art solid-state NMR methods and integration of hybrid approaches to elucidate the assembly mechanisms, revealing the weak interactions at the supramolecular interfaces. The project comprises three different aspects of growing complexity: (1) Elaboration of a proof-of-concept for atomic resolution structure determination of self-assembled nanotubes in hydrogel form. (2) Determination of the structural basis for bacterial filaments (3) Investigation of the phenomenon of heterogeneous supramolecular templating, in the context of amyloid fold initiation. One major aim of Weakinteract is to provide a robust approach dedicated to chemists, biophysicists and structural biologists in order to tackle weak interactions in the relevant assembled state, ultimately delivering atomic level structures and an understanding of the assembly process.

 Publications

year authors and title journal last update
List of publications.
2017 Denis Martinez, Marion Decossas, Julia Kowal, Lukas Frey, Henning Stahlberg, Erick J. Dufourc, Roland Riek, Birgit Habenstein, Stefan Bibow, Antoine Loquet
Lipid Internal Dynamics Probed in Nanodiscs
published pages: 2651-2657, ISSN: 1439-4235, DOI: 10.1002/cphc.201700450
ChemPhysChem 18/19 2019-05-29
2017 Antoine Loquet, Sven Saupe
Diversity of Amyloid Motifs in NLR Signaling in Fungi
published pages: 38, ISSN: 2218-273X, DOI: 10.3390/biom7020038
Biomolecules 7/4 2019-05-29
2017 Antoine Loquet, James Tolchard, Melanie Berbon, Denis Martinez, Birgit Habenstein
Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
published pages: , ISSN: 1940-087X, DOI: 10.3791/55779
Journal of Visualized Experiments 127 2019-05-29
2018 Antoine Loquet, Nadia El Mammeri, Jan Stanek, Mélanie Berbon, Benjamin Bardiaux, Guido Pintacuda, Birgit Habenstein
3D structure determination of amyloid fibrils using solid-state NMR spectroscopy
published pages: , ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2018.03.014
Methods 2019-05-29
2017 Julien Gronnier, Jean-Marc Crowet, Birgit Habenstein, Mehmet Nail Nasir, Vincent Bayle, Eric Hosy, Matthieu Pierre Platre, Paul Gouguet, Sylvain Raffaele, Denis Martinez, Axelle Grelard, Antoine Loquet, Françoise Simon-Plas, Patricia Gerbeau-Pissot, Christophe Der, Emmanuelle M Bayer, Yvon Jaillais, Magali Deleu, Véronique Germain, Laurence Lins, Sébastien Mongrand
Structural basis for plant plasma membrane protein dynamics and organization into functional nanodomains
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.26404
eLife 6 2019-05-29
2017 Birgit Habenstein, Antoine Loquet
Bacterial Filamentous Appendages Investigated by Solid-State NMR Spectroscopy.
published pages: 415-448, ISSN: , DOI: 10.1007/978-1-4939-7033-9_29
Bacterial Protein Secretion Systems: Methods and Protocols 2019-05-29
2018 Denis Martinez, Anthony Legrand, Julien Gronnier, Marion Decossas, Paul Gouguet, Olivier Lambert, Mélanie Berbon, Loris Verron, Axelle Grélard, Veronique Germain, Antoine Loquet, Sébastien Mongrand, Birgit Habenstein
Coiled-coil oligomerization controls localization of the plasma membrane REMORINs
published pages: , ISSN: 1047-8477, DOI: 10.1016/j.jsb.2018.02.003
Journal of Structural Biology 2019-05-29
2018 James Tolchard, Manoj Kumar Pandey, Mélanie Berbon, Abdelmajid Noubhani, Sven J Saupe, Yusuke Nishiyama, Birgit Habenstein, Antoine Loquet
Detection of side-chain proton resonances of fully protonated biosolids in nano-litre volumes by magic angle spinning solid-state NMR
published pages: 177-185, ISSN: 0925-2738, DOI: 10.1007/s10858-018-0168-3
Journal of Biomolecular NMR 70/3 2019-05-29
2016 Jan Stanek, Loren B. Andreas, Kristaps Jaudzems, Diane Cala, Daniela Lalli, Andrea Bertarello, Tobias Schubeis, Inara Akopjana, Svetlana Kotelovica, Kaspars Tars, Andrea Pica, Serena Leone, Delia Picone, Zhi-Qiang Xu, Nicholas E. Dixon, Denis Martinez, Mélanie Berbon, Nadia El Mammeri, Abdelmajid Noubhani, Sven Saupe, Birgit Habenstein, Antoine Loquet, Guido Pintacuda
NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils
published pages: 15504-15509, ISSN: 1433-7851, DOI: 10.1002/anie.201607084
Angewandte Chemie International Edition 55/50 2019-05-29
2016 Asen Daskalov, Birgit Habenstein, Raimon Sabaté, Mélanie Berbon, Denis Martinez, Stéphane Chaignepain, Bénédicte Coulary-Salin, Kay Hofmann, Antoine Loquet, Sven J. Saupe
Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis
published pages: 2720-2725, ISSN: 0027-8424, DOI: 10.1073/pnas.1522361113
Proceedings of the National Academy of Sciences 113/10 2019-05-29
2018 Antoine Loquet, Sven J. Saupe, Diego Romero
Functional Amyloids in Health and Disease
published pages: 3629-3630, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.07.024
Journal of Molecular Biology 430/20 2019-03-12
2019 Madhihalli Basavaraju Divakara, Denis Martinez, Ashwini Ravi, Veer Bhavana, Venkata Ramana, Birgit Habenstein, Antoine Loquet, Mysore Sridhar Santosh
Molecular mechanisms for the destabilization of model membranes by islet amyloid polypeptide
published pages: 34-40, ISSN: 0301-4622, DOI: 10.1016/j.bpc.2018.12.002
Biophysical Chemistry 245 2019-03-12
2018 Julien Meca, Aurélie Massoni‐Laporte, Denis Martinez, Elodie Sartorel, Antoine Loquet, Birgit Habenstein, Derek McCusker
Avidity‐driven polarity establishment via multivalent lipid–GTPase module interactions
published pages: e99652, ISSN: 0261-4189, DOI: 10.15252/embj.201899652
The EMBO Journal 2019-03-12
2018 Antoine Baudin, Anne Guichard, Gavin W. Collie, Sabrina Rousseau, Stéphane Chaignepain, Agnès Hocquellet, Mélanie Berbon, Antoine Loquet, Cameron Mackereth, Gilles Guichard, Benoît Odaert
1H, 13C, 15N NMR resonance assignments and secondary structure determination of the extra-cellular domain from the human proapoptotic TRAIL-R2 death receptor 5 (DR5-ECD)
published pages: 309-314, ISSN: 1874-2718, DOI: 10.1007/s12104-018-9828-1
Biomolecular NMR Assignments 12/2 2019-03-06

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