Explore the words cloud of the CatHet project. It provides you a very rough idea of what is the project "CatHet" about.
The following table provides information about the project.
Coordinator |
UNIVERSITY OF BRISTOL
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | https://bowerresearchgroup.wordpress.com/ |
Total cost | 1˙548˙738 € |
EC max contribution | 1˙548˙738 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-STG |
Funding Scheme | ERC-STG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-04-01 to 2020-03-31 |
Take a look of project's partnership.
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1 | UNIVERSITY OF BRISTOL | UK (BRISTOL) | coordinator | 1˙548˙738.00 |
Medicinal chemistry requires more efficient and diverse methods for the asymmetric synthesis of chiral scaffolds. Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers. There is a compelling correlation between drug candidate “chiral complexity” and the likelihood of progression to the marketplace. Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time, for the reasons mentioned above, the “chiral complexity” of marketed drugs has increased. Since the mid-1990s, there has been a notable acceleration of this “complexity divergence”. Consequently, there is now an urgent need to provide efficient processes that directly access privileged chiral scaffolds. It is our philosophy that catalysis holds the key here and new processes should be based upon platforms that can exert control over both absolute and relative stereochemistry. In this proposal we outline the development of a range of N-heteroannulation processes based upon the catalytic generation and trapping of unique or unusual classes of organometallic intermediate derived from transition metal insertion into C-C and C-N sigma-bonds. We will provide a variety of enabling methodologies and demonstrate applicability in flexible total syntheses of important natural product scaffolds. The processes proposed are synthetically flexible, operationally simple and amenable to asymmetric catalysis. Likely starting points, based upon preliminary results, will set the stage for the realisation of aspirational and transformative goals. Through the study of the organometallic intermediates involved here, there is potential to generalise these new catalytic manifolds, such that this research will transcend N heterocyclic chemistry to provide enabling methods for organic chemistry as a whole.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Ian R. Hazelden, Rafaela C. Carmona, Thomas Langer, Paul G. Pringle, and John F. Bower Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201801109 |
Angewandte Chemie International Edition | 2019-10-17 |
2018 |
Joshua J. Farndon, Tom A. Young, John F. Bower Stereospecific Alkene Aziridination Using a Bifunctional Amino-Reagent: An Aza-Prilezhaev Reaction published pages: 17846-17850, ISSN: 0002-7863, DOI: 10.1021/jacs.8b10485 |
Journal of the American Chemical Society 140/51 | 2019-10-17 |
2018 |
Andrew G. Dalling, John F. Bower Synthesis of Nitrogen Heterocycles via Directed Carbonylative C–C Bond Activation of Cyclopropanes published pages: 595-600, ISSN: 0009-4293, DOI: 10.2533/chimia.2018.595 |
CHIMIA International Journal for Chemistry 72/9 | 2019-10-17 |
2019 |
Xiaofeng Ma, Ian R. Hazelden, Thomas Langer, Rachel H. Munday, John F. Bower Enantioselective Aza-Heck Cyclizations of N -(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines published pages: 3356-3360, ISSN: 0002-7863, DOI: 10.1021/jacs.8b12689 |
Journal of the American Chemical Society 141/8 | 2019-10-17 |
2019 |
Olivia Boyd, Gangwei Wang, Olga Sokolova, Adam Calow, Sophie Bertrand, John Bower Modular Access to Eight-Membered N-Heterocycles by Directed Carbonylative C-C Bond Activation of Aminocyclopropanes published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201910276 |
Angewandte Chemie International Edition | 2019-10-17 |
2018 |
Simon Grélaud, Phillippa Cooper, Lyman J. Feron, John F. Bower Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition published pages: 9351-9356, ISSN: 0002-7863, DOI: 10.1021/jacs.8b04627 |
Journal of the American Chemical Society 140/30 | 2019-10-17 |
2018 |
Gang-Wei Wang, John F. Bower Modular Access to Azepines by Directed Carbonylative C–C Bond Activation of Aminocyclopropanes published pages: 2743-2747, ISSN: 0002-7863, DOI: 10.1021/jacs.7b13087 |
Journal of the American Chemical Society 140/8 | 2019-10-17 |
2019 |
Andrew G. Dalling, Takayuki Yamauchi, Niall G. McCreanor, Lydia Cox, John F. Bower Carbonylative C−C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides published pages: 221-225, ISSN: 1433-7851, DOI: 10.1002/anie.201811460 |
Angewandte Chemie International Edition 58/1 | 2019-10-17 |
2017 |
Gabriele Fumagalli, Steven Stanton, and John F. Bower Recent Methodologies That Exploit C−C Single-Bond Cleavage of Strained Ring Systems by Transition Metal Complexes published pages: , ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.6b00599 |
Chemical Reviews | 2019-10-17 |
2017 |
Nicholas J. Race, Adele Faulkner, Gabriele Fumagalli, Takayuki Yamauchi, James S. Scott, Marie Rydén-Landergren, Hazel A. Sparkes, John F. Bower Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters published pages: 1981-1985, ISSN: 2041-6520, DOI: 10.1039/c6sc04466b |
Chem. Sci. 8/3 | 2019-05-29 |
2017 |
Xiaofeng Ma, Joshua J. Farndon, Tom A. Young, Natalie Fey, John F. Bower A Simple and Broadly Applicable C−N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents published pages: 14531-14535, ISSN: 1433-7851, DOI: 10.1002/anie.201708176 |
Angewandte Chemie International Edition 56/46 | 2019-05-29 |
2017 |
Craig S. Buxton, David C. Blakemore, John F. Bower Reductive Coupling of Acrylates with Ketones and Ketimines by a Nickel-Catalyzed Transfer-Hydrogenative Strategy published pages: 13824-13828, ISSN: 1433-7851, DOI: 10.1002/anie.201707531 |
Angewandte Chemie International Edition 56/44 | 2019-05-29 |
2016 |
Megan H. Shaw, John F. Bower Synthesis and applications of rhodacyclopentanones derived from C–C bond activation published pages: 10817-10829, ISSN: 1359-7345, DOI: 10.1039/C6CC04359C |
Chem. Commun. 52/72 | 2019-05-29 |
2016 |
Gang-Wei Wang, Niall G. McCreanor, Megan H. Shaw, William G. Whittingham, John F. Bower New Initiation Modes for Directed Carbonylative C–C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.6b08608 |
Journal of the American Chemical Society | 2019-05-29 |
2016 |
Ian R. Hazelden, Xiaofeng Ma, Thomas Langer, John F. Bower Diverse N -Heterocyclic Ring Systems via Aza-Heck Cyclizations of N -(Pentafluorobenzoyloxy)sulfonamides published pages: 11198-11202, ISSN: 1433-7851, DOI: 10.1002/anie.201605152 |
Angewandte Chemie International Edition 55/37 | 2019-05-29 |
2015 |
Megan H. Shaw, Rosemary A. Croft, William G. Whittingham, John F. Bower Modular Access to Substituted Azocanes via a Rhodium-Catalyzed Cycloaddition–Fragmentation Strategy published pages: 8054-8057, ISSN: 0002-7863, DOI: 10.1021/jacs.5b05215 |
Journal of the American Chemical Society 137/25 | 2019-05-29 |
2016 |
Niall G. McCreanor, Steven Stanton, John F. Bower Capture–Collapse Heterocyclization: 1,3-Diazepanes by C–N Reductive Elimination from Rhodacyclopentanones published pages: 11465-11468, ISSN: 0002-7863, DOI: 10.1021/jacs.6b07046 |
Journal of the American Chemical Society 138/36 | 2019-05-29 |
2017 |
Joshua J. Farndon, Xiaofeng Ma, John F. Bower Transition Metal Free C–N Bond Forming Dearomatizations and Aryl C–H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent published pages: 14005-14008, ISSN: 0002-7863, DOI: 10.1021/jacs.7b07830 |
Journal of the American Chemical Society 139/40 | 2019-05-29 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CATHET" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
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The information about "CATHET" are provided by the European Opendata Portal: CORDIS opendata.
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