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MEL-PLEX SIGNED

Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MEL-PLEX project word cloud

Explore the words cloud of the MEL-PLEX project. It provides you a very rough idea of what is the project "MEL-PLEX" about.

academia significantly superior treatment countries network personalised signatures co 15 centre validate personalising prognosis melanoma plex medicine responsiveness intersectoral options etn patient leaders understand combination navigate international biology chemotherapy foundation molecular mindset novel progression academic rcsi therapies 11 environments disciplines optimising unmatched trained creative disease signalling industry spans tools newly models heterogeneous mel computational explored private therapy confidently training clinically quantitative biomedical biomarker regulation beneficiaries resistant clinical cancer innovative train stage interdisciplinary collaborations mechanistic cancers environment translational coordinated predictive mathematics malignant progress

Project "MEL-PLEX" data sheet

The following table provides information about the project.

Coordinator	ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.melplex.eu
Total cost	3˙583˙870 €
EC max contribution	3˙583˙870 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2014
Duration (year-month-day)	from 2014-12-01 to 2018-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ROYAL COLLEGE OF SURGEONS IN IRELAND ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	184˙496.00
2	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	501˙120.00
3	UNIVERSITE DU LUXEMBOURG UNIVERSITE DU LUXEMBOURG Organization address address: 2 AVENUE DE L'UNIVERSITE city: ESCH-SUR-ALZETTE postcode: 4365 website: http://wwwen.uni.lu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (ESCH-SUR-ALZETTE)	participant	501˙120.00
4	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	498˙432.00
5	UNIVERSITAET STUTTGART UNIVERSITAET STUTTGART Organization address address: KEPLERSTRASSE 7 city: STUTTGART postcode: 70174 website: www.uni-stuttgart.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	participant	477˙664.00
6	KRAEFTENS BEKAEMPELSE KRAEFTENS BEKAEMPELSE Organization address address: STRANDBOULEVARDEN 49 city: KOEBENHAVN postcode: 2100 website: http://www.cancer.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOEBENHAVN)	participant	290˙081.00
7	ONCOMARK LIMITED ONCOMARK LIMITED Organization address address: 172 RATHGAR ROAD RATHGAR city: DUBLIN postcode: Dublin 6 website: www.oncomark.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	265˙674.00
8	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	265˙674.00
9	OPTIMATA LTD OPTIMATA LTD Organization address address: 20 ZICHRON YAA'KOV ST. city: TEL AVIV postcode: 6299920 website: www.optimata.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	participant	260˙300.00
10	PROTATOUANS - ETAIREIA EREYNAS VIOTECHNOLOGIAS MONOPROSOPI ETAIREIA PERIORISMENIS EYTHINIS PROTATOUANS - ETAIREIA EREYNAS VIOTECHNOLOGIAS MONOPROSOPI ETAIREIA PERIORISMENIS EYTHINIS Organization address address: ODOS NAVARCHOU VOTSI 3 city: GLYFADA postcode: 16675 website: www.protATonce.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (GLYFADA)	participant	242˙386.00
11	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	55˙381.00
12	UNIVERSITAETSKLINIKUM AACHEN UNIVERSITAETSKLINIKUM AACHEN Organization address address: Pauwelsstrasse 30 city: AACHEN postcode: 52074 website: www.ukaachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	41˙536.00
13	A. Plaisant Srl. A. Plaisant Srl. Organization address address: n.a. city: Roma postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Roma)	partner	0.00
14	Apogenix Apogenix Organization address address: IM NEUENHEIMER FELD 584 city: HEIDELBERG postcode: 69120 website: www.apogenix.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	partner	0.00
15	Galderma Galderma Organization address address: n.a. city: Chede postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Chede)	partner	0.00
16	Mass. General Hospital Mass. General Hospital Organization address address: n.a. city: Boston postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Boston)	partner	0.00
17	Merrimack Merrimack Organization address address: n.a. city: North Andover postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (North Andover)	partner	0.00
18	Novartis Novartis Organization address address: ROONSTRASSE 25 city: NURNBERG postcode: 90429 website: www.novartis.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NURNBERG)	partner	0.00
19	THE HEBREW UNIVERSITY OF JERUSALEM THE HEBREW UNIVERSITY OF JERUSALEM Organization address address: EDMOND J SAFRA CAMPUS GIVAT RAM city: JERUSALEM postcode: 91904 website: www.huji.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	partner	0.00
20	University Berne University Berne Organization address address: n.a. city: Berne postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Berne)	partner	0.00

Map

Project objective

Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines and the associated European training needs provide the foundation for the MEL-PLEX ETN. MEL-PLEX aims to understand the network-level and multi-scale regulation of disease-relevant signalling in melanoma through a combination of quantitative biomedical and computational research approaches that go significantly beyond the current state-of-the-art. Coordinated by the RCSI Centre for Systems Medicine, MEL-PLEX will train 15 early stage researchers through a highly interdisciplinary and intersectoral research training programme. MEL-PLEX comprises 11 beneficiaries and 7 partner organisations from 11 countries, including European and international leaders in personalised melanoma therapy, melanoma systems biology and cancer systems medicine. MEL-PLEX aims to (i) achieve an unmatched depth of molecular and mechanistic disease understanding, (ii) will exploit this knowledge to develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iii) will provide superior and clinically relevant tools and biomarker signatures for personalising and optimising melanoma treatment. The MEL-PLEX ETN addresses current needs in academia and the private sector for researchers that have been trained in an environment that spans across biology, medicine and mathematics, that can navigate confidently between clinical, academic and private sector research environments, and that have developed an innovative and creative mindset to progress research findings towards applications.

Deliverables

List of deliverables.
Dissemination report 3	Documents, reports	2019-10-08 17:03:05
MEL-PLEX conference	Other	2019-10-08 17:03:06
Final dissemination report	Documents, reports	2019-10-08 17:03:07
Website	Websites, patent fillings, videos etc.	2019-10-08 16:55:03
Dissemination report 2	Documents, reports	2019-10-08 16:55:02
Dissemination report 1	Documents, reports	2019-10-08 16:54:55

Take a look to the deliverables list in detail: detailed list of MEL-PLEX deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Bruce Moran, Romina Silva, Antoinette S. Perry, William M. Gallagher Epigenetics of malignant melanoma published pages: 80-88, ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2017.10.006	Seminars in Cancer Biology 51	2019-10-08
2018	SÃ©bastien De Landtsheer, Philippe Lucarelli, Thomas Sauter Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00550	Frontiers in Physiology 9	2019-10-08
2018	Erminia Romano, Nicole Rufo, Hannelie Korf, Chantal Mathieu, Abhishek D. Garg, Patrizia Agostinis BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.24815	Oncotarget 9/25	2019-10-08
2018	Jan RoÅ¾anc, Theodore Sakellaropoulos, Asier Antoranz, Cristiano GuttÃ , Biswajit Podder, Vesna Vetma, Nicole Rufo, Patrizia Agostinis, Vaia Pliaka, Thomas Sauter, Dagmar Kulms, Markus Rehm, Leonidas G. Alexopoulos Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma published pages: , ISSN: 1350-9047, DOI: 10.1038/s41418-018-0210-8	Cell Death & Differentiation	2019-10-08
2018	Kotryna Seip, Kjetil JÃ¸rgensen, Marco Vincent Haselager, Marco Albrecht, Mads Haugland Haugen, Eivind Valen Egeland, Philippe Lucarelli, Olav Engebraaten, Thomas Sauter, Gunhild Mari MÃ¦landsmo, Lina Prasmickaite Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment published pages: 1-13, ISSN: 0304-3835, DOI: 10.1016/j.canlet.2018.09.023	Cancer Letters 439	2019-10-08
2017	Maddalena Maria Bolognesi, Marco Manzoni, Carla Rossana Scalia, Stefano Zannella, Francesca Maria Bosisio, Mario Faretta, Giorgio Cattoretti Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections published pages: 431-444, ISSN: 0022-1554, DOI: 10.1369/0022155417719419	Journal of Histochemistry & Cytochemistry 65/8	2019-10-08
2018	Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia GÃ³mez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling published pages: 161-179.e14, ISSN: 2405-4712, DOI: 10.1016/j.cels.2018.06.002	Cell Systems 7/2	2019-10-08
2018	Greta Del Mistro, Philippe Lucarelli, Ines MÃ¼ller, SÃ©bastien De Landtsheer, Anna Zinoveva, Meike Hutt, Martin Siegemund, Roland E. Kontermann, Stefan Beissert, Thomas Sauter, Dagmar Kulms Systemic network analysis identifies XIAP and IÎºBÎ± as potential drug targets in TRAIL resistant BRAF mutated melanoma published pages: , ISSN: 2056-7189, DOI: 10.1038/s41540-018-0075-y	npj Systems Biology and Applications 4/1	2019-10-08
2017	Nicole Rufo, Abhishek D. Garg, Patrizia Agostinis The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy published pages: , ISSN: 2405-8033, DOI: 10.1016/j.trecan.2017.07.002	Trends in Cancer	2019-10-08
2016	Francesca M Bosisio, James S Wilmott, Nathalie Volders, Marjorie Mercier, Jasper Wouters, Marguerite Stas, Willeke AM Blokx, Daniela Massi, John F Thompson, Richard A Scolyer, Nicolas van Baren, Joost J van den Oord Plasma cells in primary melanoma. Prognostic significance and possible role of IgA published pages: 347-358, ISSN: 0893-3952, DOI: 10.1038/modpathol.2016.28	Modern Pathology 29/4	2019-10-08
2017	Vesna Vetma, Jan RoÅ¾anc, Emilie M Charles, Christian T Hellwig, Leonidas G Alexopoulos, Markus Rehm Examining the In-Vitro Efficacy of the IAP Antagonist Birinapant as a Single-Agent or in Combination with Dacarbazine to Induce Melanoma Cell Death published pages: , ISSN: 0965-0407, DOI: 10.3727/096504017X14897145996933	Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics	2019-10-08
2016	A D Garg, E Romano, N Rufo, P Agostinis Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation published pages: 938-951, ISSN: 1350-9047, DOI: 10.1038/cdd.2016.5	Cell Death and Differentiation 23/6	2019-10-08
2017	Marco Albrecht, Damian Stichel, Benedikt MÃ¼ller, Ruth Merkle, Carsten Sticht, Norbert Gretz, Ursula KlingmÃ¼ller, Kai Breuhahn and Franziska MatthÃ¤us TTCA: an R package for the identification of differentially expressed genes in time course microarray data published pages: , ISSN: 1471-2105, DOI: 10.1186/s12859-016-1440-8	BMC Bioinformatics	2019-10-08
2016	Joost J van den Oord; Bosisio, Francesca Maria Immunoplasticity in cutaneous melanoma: beyond pure morphology published pages: , ISSN: 0945-6317, DOI: 10.1007/s00428-016-2058-y	Virchows Archiv 1	2019-10-08
2017	Bruce Moran, Arman Rahman, Katja Palonen, Fiona T. Lanigan, William M. Gallagher Master Transcriptional Regulators in Cancer: Discovery via Reverse Engineering Approaches and Subsequent Validation published pages: 2186-2190, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-1813	Cancer Research 77/9	2019-10-08
2017	SÃ©bastien De Landtsheer, Panuwat Trairatphisan, Philippe Lucarelli, Thomas Sauter FALCON: a toolbox for the fast contextualization of logical networks published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btx380	Bioinformatics	2019-10-08
2015	Abhishek D. Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B. Birge, JosÃ© Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G. Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M. Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S. Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R. Hamblin, Akseli Hemminki, M Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2015.00588	Frontiers in Immunology 6	2019-10-08
2016	Marco Albrecht, Giuseppe Sciume, Philippe Lucarelli, Thomas Sauter Thermodynamically constrained averaging theory for cancer growth modelling published pages: , ISSN: , DOI: 10.1016/j.ifacol.2016.12.141	IFAC Papers Online 49/26	2019-10-08

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