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BonePain

European Training Network on Bone Pain

Total Cost €

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EC-Contrib. €

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Partnership

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 BonePain project word cloud

Explore the words cloud of the BonePain project. It provides you a very rough idea of what is the project "BonePain" about.

validate    interdisciplinary    therapeutic    biology    stages    encompasses    fracture    skills    multidisciplinary    secondments    ranging    society    academic    neuronal    treatment    modulation    millions    extensive    infiltrated    arthritis    phd    metastasis    first    pharmacology    quality    form    transgenic    negative    innovative    effort    education    patients    europe    cancer    transferable    industrial    innovation    beneficiaries    huge    physiology    medicines    committed    frontline    tease    arthritic    mouse    transmission    vivo    tests    biobank    societal    subject    mechanisms    obtain    suffer    create    benefit    complication    subtypes    outstanding    spanning    elucidate    platform    students    debilitating    pain    disorders    training    despite    bone    electrophysiology    sophisticated    foremost    treatments    demands    truly    strategies    musculoskeletal    human    models    pathophysiology    patterns    humans    networks    life    neuroscience    network    international    expression    receptor   

Project "BonePain" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.bonepain.eu
 Total cost 3˙558˙676 €
 EC max contribution 3˙558˙676 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 580˙163.00
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 819˙863.00
3    NORDIC BIOSCIENCE A/S DK (HERLEV) participant 580˙163.00
4    THE ROYAL VETERINARY COLLEGE UK (LONDON) participant 546˙575.00
5    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 527˙318.00
6    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 255˙374.00
7    GRUNENTHAL GMBH DE (AACHEN) participant 249˙216.00
8    NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S DK (Helev) participant 0.00
9    TRANSPHARMATION LTD UK (LONDON) partner 0.00

Map

 Project objective

The aim is to create an innovative European PhD training network in bone pain. Millions in Europe and beyond suffer from bone pain, a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. However, being a truly multidisciplinary subject spanning neuroscience, bone biology, and even cancer research, it demands a multidisciplinary approach. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is available. To address this societal challenge and the strong innovation potential, we want to form the first European platform to promote frontline research, innovation and education within bone pain. The network encompasses 5 academic and 2 industrial beneficiaries and 1 industrial partner all committed to creating an outstanding wide-ranging yet integrated training program for early stages researchers to elucidate the mechanisms of bone pain and develop new medicines. We will use in vivo models of arthritic pain, cancer-induced bone pain and fracture pain to investigate the pathophysiology and novel treatment strategies. In vivo electrophysiology will be used for studying the physiology and pharmacology of pain transmission and its modulation. Transgenic mouse models will be used to tease out the specific neuronal receptor subtypes involved. Sophisticated behaviour tests will evaluate response to novel treatments. We will create a biobank of human cancer-infiltrated bone to identify specific patterns of neuronal receptor expression and to validate therapeutic targets in humans. In an extensive training effort covering both specific research skills and transferable skills, the students will obtain an interdisciplinary, state-of-the-art and innovative training from the participants, several of which have experience from international networks. The students will benefit from secondments with industrial partners and with some of the foremost pain researchers in Europe

 Deliverables

List of deliverables.
Degree Award Documents, reports 2020-01-20 16:54:37
Public outreach Other 2020-01-20 16:54:37
Papers Other 2020-01-20 16:54:37
Website (2) Websites, patent fillings, videos etc. 2020-01-20 16:54:37
Dissemination training Other 2020-01-20 16:54:37
International aspect Other 2020-01-20 16:54:37
Midterm review Meeting Documents, reports 2020-01-20 16:54:36
Recruitment Other 2020-01-20 16:54:36
Website (1) Websites, patent fillings, videos etc. 2020-01-20 16:54:36
Ethics Documents, reports 2020-01-20 16:54:36

Take a look to the deliverables list in detail:  detailed list of BonePain deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Ramin Raoof, Hanneke L D M Willemen, Niels Eijkelkamp
Divergent roles of immune cells and their mediators in pain
published pages: 429-440, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kex308
Rheumatology 57/3 2020-01-20
2019 Teresa Fernandez-Zafra, Tianle Gao, Alexandra Jurczak, Katalin Sandor, Zoe Hore, Nilesh M. Agalave, Jie Su, Johanna Estelius, Jon Lampa, Tomas Hokfelt, Zsuzsanna Wiesenfeld-Hallin, Xiaojun Xu, Franziska Denk, Camilla I. Svensson
Exploring the transcriptome of resident spinal microglia after collagen antibody–induced arthritis
published pages: 224-236, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001394
PAIN 160/1 2020-01-20
2018 M.A. Bangash, Sascha R.A. Alles, Sonia Santana-Varela, Queensta Millet, Shafaq Sikandar, Larissa de Clauser, Freija ter Heegde, Abdella M. Habib, Vanessa Pereira, Jane E. Sexton, Edward C. Emery, Shengnan Li, Ana P. Luiz, Janka Erdos, Samuel J. Gossage, Jing Zhao, James J. Cox, John N. Wood
Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions
published pages: 78, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14641.1
Wellcome Open Research 3 2020-01-20
2018 Ryan Patel, Carlota Montagut-Bordas, Anthony H Dickenson
Calcium channel modulation as a target in chronic pain control
published pages: 2173-2184, ISSN: 0007-1188, DOI: 10.1111/bph.13789
British Journal of Pharmacology 175/12 2020-01-20
2018 Marta Diaz-delCastillo, David P.D. Woldbye, Anne Marie Heegaard
Neuropeptide Y and its Involvement in Chronic Pain
published pages: 162-169, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.08.050
Neuroscience 387 2020-01-20
2019 Freija ter Heegde, Ana P. Luiz, Sonia Santana-Varela, Iain P. Chessell, Fraser Welsh, John N. Wood, Chantal Chenu
Non-invasive mechanical joint loading as an alternative model for osteoarthritic pain
published pages: , ISSN: 2326-5191, DOI: 10.1002/art.40835
Arthritis & Rheumatology 2020-01-20
2017 Maja R. Radojčić, Christian S. Thudium, Kim Henriksen, Keith Tan, Rolf Karlsten, Amanda Dudley, Iain Chessell, Morten A. Karsdal, Anne-Christine Bay-Jensen, Michel D. Crema, Ali Guermazi
Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients
published pages: 1254-1263, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000908
PAIN 158/7 2020-01-20
2017 Camilla Kristine Appel, Simone Gallego-Pedersen, Line Andersen, Sophie Blancheflor Kristensen, Ming Ding, Sarah Falk, Manasi Sayilekshmy, Charlotte Gabel-Jensen, Anne-Marie Heegaard
The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05029-1
Scientific Reports 7/1 2020-01-20
2017 Kirsty Bannister, Mateusz Kucharczyk, Anthony H. Dickenson
Hopes for the Future of Pain Control
published pages: 117-128, ISSN: 2193-8237, DOI: 10.1007/s40122-017-0073-6
Pain and Therapy 6/2 2020-01-20
2019 Anna Katri, Aneta Dąbrowska, Henrik Löfvall, Ming Ding, Morten A. Karsdal, Kim V. Andreassen, Christian S. Thudium, Kim Henriksen
Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model
published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-019-1819-9
Arthritis Research & Therapy 21/1 2020-01-20
2019 Ryan Patel, Mateusz Kucharczyk, Carlota Montagut-Bordas, Stevie Lockwood, Anthony H. Dickenson
Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back-translational study of oxcarbazepine
published pages: 183-197, ISSN: 1090-3801, DOI: 10.1002/ejp.1300
European Journal of Pain 23/1 2020-01-20
2018 Emerson Krock, Alexandra Jurczak, Camilla I. Svensson
Pain pathogenesis in rheumatoid arthritis—what have we learned from animal models?
published pages: S98-S109, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001333
PAIN 159 2020-01-20
2016 Bas DB, Rudjito R, Wigerblad G, Su Jie and Svensson CI
Involvement of inflammatory mediators in arthritis-induced pain:what do experimental models tell us?
published pages: , ISSN: , DOI:
Ch. 21. Pain 2016: Refresher course, 16th World Congress on Pain 2020-01-20
2018 Marta Diaz-delCastillo, Søren H. Christiansen, Camilla K. Appel, Sarah Falk, David P.D. Woldbye, Anne-Marie Heegaard
Neuropeptide Y is Up-regulated and Induces Antinociception in Cancer-induced Bone Pain
published pages: 111-119, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2018.05.025
Neuroscience 384 2020-01-20

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The information about "BONEPAIN" are provided by the European Opendata Portal: CORDIS opendata.

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