Explore the words cloud of the FORCASTER project. It provides you a very rough idea of what is the project "FORCASTER" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||2˙199˙310 €|
|EC max contribution||2˙199˙310 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-12-31|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||2˙199˙310.00|
Cells must move and position internal components to perform their function. We here focus on the physical designs which allow microtubule (MT) asters to exert forces in order to move and position themselves in vivo. These are arrays of MTs radiating from the centrosome, which fill up large portions of cells. They orchestrate nuclear positioning and spindle orientation for polarity, division and development. Forces that move asters are generated at nanometer and second scales by MT-associated motors from sites in the cytoplasm or at the cell surface. How MTs and force-generators self-organize to control aster motion and position at millimeter and hour scales is not known. We will use a suit of biophysical experiments and models to address how aster micro-mechanics contribute to aster migration, centration, de-centration and orientation in a single in vivo system, using the early stages of Sea urchin development as a quantitative model. We aim to: 1) Elucidate mechanisms that drive aster large-scale motion, using sperm aster migration after fertilization during which asters grow and move rapidly and persistently to the large-egg center. We will investigate how speeds and trajectories depend on boundary conditions and on the dynamic spatial organization of force-generators. 2) Implement magnetic-based subcellular force measurements of MT asters. We will use this to understand how single force-events are integrated at the scale of asters, how global forces may evolve will aster size, shape, in centration and de-centration processes, using various stages of development, and cell manipulation; and to compute aster friction. 3) Couple computational models and 3D imaging to understand and predict stereotyped division patterns driven by subsequent aster positioning and aster-pairs orientation in the early divisions of Sea urchin embryos and in other tissues. This framework bridging multiple scales will bring unprecedented insights on the physics of living active matter.
|year||authors and title||journal||last update|
Jing Xie, Nicolas Minc
Cytoskeleton Force Exertion in Bulk Cytoplasm
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2020.00069
|Frontiers in Cell and Developmental Biology 8||2020-02-19|
Valeria DavÃ¬, Louis Chevalier, Haotian Guo, Hirokazu Tanimoto, Katia Barrett, Etienne Couturier, Arezki Boudaoud, Nicolas Minc
Systematic mapping of cell wall mechanics in the regulation of cell morphogenesis
published pages: 13833-13838, ISSN: 0027-8424, DOI: 10.1073/pnas.1820455116
|Proceedings of the National Academy of Sciences 116/28||2019-12-16|
Armin Haupt, Dmitry Ershov, Nicolas Minc
A Positive Feedback between Growth and Polarity Provides Directional Persistency and Flexibility to the Process of Tip Growth
published pages: 3342-3351.e3, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.09.022
|Current Biology 28/20||2019-08-06|
JÃ©rÃ©my SallÃ©, Jing Xie, Dmitry Ershov, Milan Lacassin, Serge Dmitrieff, Nicolas Minc
Asymmetric division through a reduction of microtubule centering forces
published pages: 771-782, ISSN: 0021-9525, DOI: 10.1083/jcb.201807102
|The Journal of Cell Biology 218/3||2019-08-06|
Hirokazu Tanimoto, Akatsuki Kimura, Nicolas Minc
Shapeâ€“motion relationships of centering microtubule asters
published pages: 777-787, ISSN: 0021-9525, DOI: 10.1083/jcb.201510064
|The Journal of Cell Biology 212/7||2019-08-06|
AnaÃ«lle Pierre, JÃ©rÃ©my SallÃ©, Martin WÃ¼hr, Nicolas Minc
Generic Theoretical Models to Predict Division Patterns of Cleaving Embryos
published pages: 667-682, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2016.11.018
|Developmental Cell 39/6||2019-08-06|
Valeria DavÃ¬, Hirokazu Tanimoto, Dmitry Ershov, Armin Haupt, Henry De Belly, RÃ©mi Le Borgne, Etienne Couturier, Arezki Boudaoud, Nicolas Minc
Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival
published pages: 170-182.e7, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.03.022
|Developmental Cell 45/2||2019-08-06|
Armin Haupt, Nicolas Minc
How cells sense their own shape â€“ mechanisms to probe cell geometry and their implications in cellular organization and function
published pages: jcs214015, ISSN: 0021-9533, DOI: 10.1242/jcs.214015
|Journal of Cell Science 131/6||2019-08-06|
Hirokazu Tanimoto, Jeremy SallÃ©, Louise Dodin, Nicolas Minc
Physical forces determining the persistency and centring precision of microtubule asters
published pages: , ISSN: 1745-2473, DOI: 10.1038/s41567-018-0154-4
Benjamin Lacroix, GaÃ«lle Letort, Laras Pitayu, JÃ©rÃ©my SallÃ©, Marine Stefanutti, Gilliane Maton, Anne-Marie Ladouceur, Julie C. Canman, Paul S. Maddox, Amy S. Maddox, Nicolas Minc, FranÃ§ois NÃ©dÃ©lec, Julien Dumont
Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing
published pages: 496-511.e6, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.04.022
|Developmental Cell 45/4||2019-08-06|
H. Tanimoto, N. Minc
Quantitative approaches for the study of microtubule aster motion in large eggs
published pages: 69-80, ISSN: , DOI: 10.1016/bs.mcb.2016.12.003
|Methods in Cell Biology 139||2019-08-06|
Daria Bonazzi, Armin Haupt, Hirokazu Tanimoto, Delphine Delacour, Delphine Salort, Nicolas Minc
Actin-Based Transport Adapts Polarity Domain Size to Local Cellular Curvature
published pages: 2677-2683, ISSN: 0960-9822, DOI: 10.1016/j.cub.2015.08.046
|Current Biology 25/20||2019-08-06|
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