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STEMCELLTRACK

Assessment of Global and Regional Cardiac Functional Improvements in a Murine Model of Myocardial Infarction following Stem Cell Treatments

Total Cost €

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EC-Contrib. €

0

Partnership

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 Outcomes and results

 STEMCELLTRACK project word cloud

Explore the words cloud of the STEMCELLTRACK project. It provides you a very rough idea of what is the project "STEMCELLTRACK" about.

cutting    scaffold    moderate    tracking    fluorine    magnetic    trans    cell    efforts    stimulated    training    therapy    scaffolds    qualities    synthesis    managerial    invasive    cdc    broadening    retention    vivo    shown    horizons    parallel    functional    injection    enriched    independent    technologies    manufacturing    cdcs    myocardial    investigator    leadership    chair    microinjection    engraftment    bio    career    cardiosphere    stem    scientific    anticipated    cardiomyopathies    validation    elicit    fiber    global    science    reinforcing    engineering    cellular    evaluation    cardiac    infarction    tools    advancing    personalized    homing    disease    plan    biomedical    fellowship    administration    edge    regenerative    applicability    quantification    techniques    mi    synergistically    mri    function    mobility    scs    19    prominent    beneficial    researcher    viability    post    resonance    sc    labeled    efficacy    heart    regional    multifaceted    labeling    characterization    imaging   

Project "STEMCELLTRACK" data sheet

The following table provides information about the project.

Coordinator		 THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://lbi-cy.com/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

Cardiosphere-derived stem cell (CDC) therapy for myocardial infarction (MI) has been shown to elicit moderate beneficial effects. Research currently focuses on improving CDC administration, retention and efficacy. This proposal aims to develop Magnetic Resonance Imaging (MRI) and engineering tools to facilitate this research. Specifically, microinjection of fluorine-19 labeled CDCs will allow for MRI tracking and quantification in vivo. Non-invasive global and regional cardiac function measurements will assess efficacy of stem cell (SC) therapy. Parallel to these studies will be an independent design, synthesis, use and evaluation of fiber-enriched scaffold. The anticipated impact will be multifaceted, including the study of cardiac function in disease, and the potential applicability of generated results with cutting edge SC regenerative technologies in heart failure and prominent cardiomyopathies. Research efforts will be stimulated in manufacturing processes for scaffolds, cardiac functional assessment post-injection of SCs, and validation of their homing, engraftment and viability using cellular tracking methods. Through a personalized career developments plan, the fellowship will allow training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing his scientific, managerial and leadership qualities. Overall, the short-term objective is the advancement of the researcher’s career in science and the broadening of his scientific horizons. The long-term objective is to establish the researcher as an independent investigator, advancing the field as a chair of a Biomedical Engineering Department.

 Publications

year authors and title journal last update
List of publications.
2016 Christakis Constantinides, Mahon L. Maguire, Sophia Malandraki-Miller, Edyta Swider, Mangala Srinivas, Carolyn A. Carr, Jurgen E. Schneider.
Fast, Quantitative 19F MRI: Optimized Imaging Strategies.
published pages: , ISSN: , DOI: 		ESMRMB 2016 2019-06-07
2016 Christakis Constantinides, Eileen McNeill, Matt Benson, Raquel Sainz Urruela, Sergi Padilla, Sophia Malandraki-Miller, Mahon L. Maguire, Edyta Swider, Sahar Ghaffari, Carolyn A. Carr, Mangala Srinivas, Jurgen E. Schneider.
Improvements in the Cellular Uptake of Perfluorocarbon Nanoparticles and 19F MRS/MRI Detectability using the Transfection Agent FuGENE.
published pages: , ISSN: , DOI: 		ISMRM Workshop on Molecular and Cellular MRI: Focus on Integration: Amsterdam, Netherlands, June 2016. 2019-06-07
2018 Christakis Constantinides, Mahon Maguire, Eileen McNeill, Ricardo Carnicer, Edyta Swider, Mangala Srinivas, Carolyn A. Carr, Jurgen E. Schneider
Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
published pages: e0190558, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190558 		PLOS ONE 13/1 2019-06-07
2016 C. Constantinides
Cardiac Image-Based Phenotyping: A Scientific Fairytale or an Emerging Reality?
published pages: 18-19, ISSN: , DOI: 		Phenotype Issue 24 2019-06-07
2017 Christakis Constantinides, Mahon L. Maguire, Leeanne Stork, Edyta Swider, Mangala Srinivas, Carolyn A. Carr, Jurgen E. Schneider
Temporal accumulation and localization of isoflurane in the C57BL/6 mouse and assessment of its potential contamination in 19 F MRI with perfluoro-crown-ether-labeled cardiac progenitor cells at 9.4 Tesla
published pages: 1659-1667, ISSN: 1053-1807, DOI: 10.1002/jmri.25564 		Journal of Magnetic Resonance Imaging 45/6 2019-06-07
2016 Christakis Constantinides, Mahon L. Maguire, Leeanne Stork, Mangala Srinivas, Edyta Swider, Carolyn A. Carr, Jurgen E. Schneider.
Effects of Inhalational Isoflurane Anaesthesia on 19F MRS/MRI of the In Vivo Mouse at 9.4T.
published pages: , ISSN: , DOI: 		ISMRM Workshop on Molecular and Cellular MRI: Focus on Integration: Amsterdam, Netherlands, June 2016. 2019-06-07
2016 Christakis Constantinides, Kathy Murphy
Molecular and Integrative Physiological Effects of Isoflurane Anesthesia: The Paradigm of Cardiovascular Studies in Rodents using Magnetic Resonance Imaging
published pages: 1-15, ISSN: 2297-055X, DOI: 10.3389/fcvm.2016.00023 		Frontiers in Cardiovascular Medicine 3 2019-06-07

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The information about "STEMCELLTRACK" are provided by the European Opendata Portal: CORDIS opendata.

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