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Assessment of Global and Regional Cardiac Functional Improvements in a Murine Model of Myocardial Infarction following Stem Cell Treatments

Total Cost €


EC-Contrib. €






 STEMCELLTRACK project word cloud

Explore the words cloud of the STEMCELLTRACK project. It provides you a very rough idea of what is the project "STEMCELLTRACK" about.

career    manufacturing    prominent    mobility    regional    efforts    cutting    retention    cellular    investigator    cardiac    edge    qualities    horizons    stimulated    resonance    science    injection    anticipated    heart    microinjection    researcher    techniques    synergistically    synthesis    fluorine    independent    tools    personalized    managerial    vivo    functional    post    myocardial    magnetic    labeling    scaffold    trans    efficacy    global    administration    bio    invasive    cdc    broadening    regenerative    evaluation    quantification    cdcs    engraftment    fellowship    engineering    beneficial    function    advancing    therapy    cardiomyopathies    moderate    homing    plan    tracking    biomedical    leadership    characterization    19    mri    viability    multifaceted    scs    fiber    parallel    sc    scientific    infarction    reinforcing    validation    mi    technologies    stem    enriched    imaging    scaffolds    cell    applicability    disease    labeled    shown    training    cardiosphere    chair    elicit   

Project "STEMCELLTRACK" data sheet

The following table provides information about the project.


Organization address
city: OXFORD
postcode: OX1 2JD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cardiosphere-derived stem cell (CDC) therapy for myocardial infarction (MI) has been shown to elicit moderate beneficial effects. Research currently focuses on improving CDC administration, retention and efficacy. This proposal aims to develop Magnetic Resonance Imaging (MRI) and engineering tools to facilitate this research. Specifically, microinjection of fluorine-19 labeled CDCs will allow for MRI tracking and quantification in vivo. Non-invasive global and regional cardiac function measurements will assess efficacy of stem cell (SC) therapy. Parallel to these studies will be an independent design, synthesis, use and evaluation of fiber-enriched scaffold. The anticipated impact will be multifaceted, including the study of cardiac function in disease, and the potential applicability of generated results with cutting edge SC regenerative technologies in heart failure and prominent cardiomyopathies. Research efforts will be stimulated in manufacturing processes for scaffolds, cardiac functional assessment post-injection of SCs, and validation of their homing, engraftment and viability using cellular tracking methods. Through a personalized career developments plan, the fellowship will allow training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing his scientific, managerial and leadership qualities. Overall, the short-term objective is the advancement of the researcher’s career in science and the broadening of his scientific horizons. The long-term objective is to establish the researcher as an independent investigator, advancing the field as a chair of a Biomedical Engineering Department.


year authors and title journal last update
List of publications.
2016 Christakis Constantinides, Mahon L. Maguire, Sophia Malandraki-Miller, Edyta Swider, Mangala Srinivas, Carolyn A. Carr, Jurgen E. Schneider.
Fast, Quantitative 19F MRI: Optimized Imaging Strategies.
published pages: , ISSN: , DOI:
ESMRMB 2016 2019-06-07
2016 Christakis Constantinides, Eileen McNeill, Matt Benson, Raquel Sainz Urruela, Sergi Padilla, Sophia Malandraki-Miller, Mahon L. Maguire, Edyta Swider, Sahar Ghaffari, Carolyn A. Carr, Mangala Srinivas, Jurgen E. Schneider.
Improvements in the Cellular Uptake of Perfluorocarbon Nanoparticles and 19F MRS/MRI Detectability using the Transfection Agent FuGENE.
published pages: , ISSN: , DOI:
ISMRM Workshop on Molecular and Cellular MRI: Focus on Integration: Amsterdam, Netherlands, June 2016. 2019-06-07
2018 Christakis Constantinides, Mahon Maguire, Eileen McNeill, Ricardo Carnicer, Edyta Swider, Mangala Srinivas, Carolyn A. Carr, Jurgen E. Schneider
Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
published pages: e0190558, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190558
PLOS ONE 13/1 2019-06-07
2016 C. Constantinides
Cardiac Image-Based Phenotyping: A Scientific Fairytale or an Emerging Reality?
published pages: 18-19, ISSN: , DOI:
Phenotype Issue 24 2019-06-07
2017 Christakis Constantinides, Mahon L. Maguire, Leeanne Stork, Edyta Swider, Mangala Srinivas, Carolyn A. Carr, Jurgen E. Schneider
Temporal accumulation and localization of isoflurane in the C57BL/6 mouse and assessment of its potential contamination in 19 F MRI with perfluoro-crown-ether-labeled cardiac progenitor cells at 9.4 Tesla
published pages: 1659-1667, ISSN: 1053-1807, DOI: 10.1002/jmri.25564
Journal of Magnetic Resonance Imaging 45/6 2019-06-07
2016 Christakis Constantinides, Mahon L. Maguire, Leeanne Stork, Mangala Srinivas, Edyta Swider, Carolyn A. Carr, Jurgen E. Schneider.
Effects of Inhalational Isoflurane Anaesthesia on 19F MRS/MRI of the In Vivo Mouse at 9.4T.
published pages: , ISSN: , DOI:
ISMRM Workshop on Molecular and Cellular MRI: Focus on Integration: Amsterdam, Netherlands, June 2016. 2019-06-07
2016 Christakis Constantinides, Kathy Murphy
Molecular and Integrative Physiological Effects of Isoflurane Anesthesia: The Paradigm of Cardiovascular Studies in Rodents using Magnetic Resonance Imaging
published pages: 1-15, ISSN: 2297-055X, DOI: 10.3389/fcvm.2016.00023
Frontiers in Cardiovascular Medicine 3 2019-06-07

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The information about "STEMCELLTRACK" are provided by the European Opendata Portal: CORDIS opendata.

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