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TentaclesOfVenom

Unravelling the enigmatic origin of venom secreting cells in sea anemone

Total Cost €

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EC-Contrib. €

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Partnership

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 TentaclesOfVenom project word cloud

Explore the words cloud of the TentaclesOfVenom project. It provides you a very rough idea of what is the project "TentaclesOfVenom" about.

toxins    assisted    pharmacological    nematocytes    developmental    genes    former    histories    starlet    gender    sites    predatory    date    limited    facs    technologies    evolutionary    understand    composition    instrumental    omics    molecular    sheds    tools    secretions    evolve    hybridization    efficient    synthesize    evolution    stages    mainly    lines    regimes    examine    contribution    vscs    cnidarians    immunostaining    biochemical    intriguing    nature    sea    first    venomous    secreting    envenoming    cocktail    arsenal    feed    hence    anemones    probably    vsc    fascinating    stinging    assays    venom    sexes    transgenic    function    encoding    vectensis    drug    reporter    till    origin    nematocyte    constructing    anemone    cells    underpinned    profiles    variation    simplest    expression    fluorescence    situ    sorting    recruitment    light    nematostella    phylogenetic    animals    cell    gland    understudied    larval    regarding    secretomes    ancient    trace   

Project "TentaclesOfVenom" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.toxickartik.com
 Total cost 182˙509 €
 EC max contribution 182˙509 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 182˙509.00

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 Project objective

Evolution of venom, nature’s most complex cocktail, has underpinned the predatory success of venomous animals. Till date, research on venom has mainly focused on how genes encoding them evolve, and our knowledge regarding the evolutionary origin of venom-secreting cells (VSCs) and their secretions, has been limited. Understanding how venom and VSCs evolve in cnidarians - one of the simplest and probably the first venomous animals, such as sea anemones is not only fascinating as it sheds light on the evolution of their ancient venom-system, but may also be instrumental in the development of efficient nematocyte (stinging-cells) based drug-delivery tools. Identifying variation in venom-composition and sites of expression across various developmental stages and between the sexes (gender-specific expression) is also an understudied topic. The former is particularly intriguing in sea anemones, as their larval stages do not feed and yet synthesize toxins. Hence, in this project I propose to: trace the evolutionary origin of known VSCs (nematocytes and gland cells) in the starlet anemone, Nematostella vectensis, by constructing transgenic reporter lines; characterize venom-secretomes of VSCs using Fluorescence Assisted Cell Sorting (FACS) to determine the contribution of each VSC towards the venom arsenal; examine variation in venom-profiles and expression sites across the developmental stages and between the sexes using ‘omics’ technologies, in situ hybridization and immunostaining; test the biochemical activities (pharmacological assays) of the major and novel toxins identified; and examine the phylogenetic histories and the molecular evolutionary regimes of the major sea anemone toxins to understand the recruitment of genes into the envenoming function in one of the first venomous animals.

 Publications

year authors and title journal last update
List of publications.
2015 Kartik Sunagar, Yehu Moran
The Rise and Fall of an Evolutionary Innovation: Contrasting Strategies of Venom Evolution in Ancient and Young Animals
published pages: e1005596, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1005596
PLOS Genetics 11/10 2019-07-23
2015 Beata Ujvari, Nicholas R. Casewell, Kartik Sunagar, Kevin Arbuckle, Wolfgang Wüster, Nathan Lo, Denis O’Meally, Christa Beckmann, Glenn F. King, Evelyne Deplazes, Thomas Madsen
Widespread convergence in toxin resistance by predictable molecular evolution
published pages: 11911-11916, ISSN: 0027-8424, DOI: 10.1073/pnas.1511706112
Proceedings of the National Academy of Sciences 112/38 2019-07-23
2018 Yaara Y Columbus-Shenkar, Maria Y Sachkova, Jason Macrander, Arie Fridrich, Vengamanaidu Modepalli, Adam M Reitzel, Kartik Sunagar, Yehu Moran
Dynamics of venom composition across a complex life cycle
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.35014
eLife 7 2019-07-23
2018 Kartik Sunagar, Yaara Y Columbus-Shenkar, Arie Fridrich, Nadya Gutkovich, Reuven Aharoni, Yehu Moran
Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone
published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-018-0578-4
BMC Biology 16/1 2019-07-23

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