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RESCUE THE HEART SIGNED

Understanding nervous mechanisms of cardioprotection to save the ischaemic and failing hearts

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RESCUE THE HEART" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.researchgate.net/project/Neural-mechanisms-of-cardioprotection
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

This project is designed to use the latest advances in molecular biology and neuroscience to determine the role played by the nervous mechanisms in the development of cardiovascular pathology. The project spans across distinct research fields of myocardial ischaemia/reperfusion injury, innate cardioprotective mechanisms and fundamental neuroscience and includes newly developed transgenic mice models and latest advances in viral gene transfer technology, pharmaco- and optogenetics for selective manipulation of parasympathetic or sympathetic efferent outflows to the heart. These novel genetic models offer unprecedented resolution and specificity and will be used to determine the role played by the autonomic nervous system in modulation of the myocardial ischaemia/reperfusion injury and progression of chronic heart failure. Another important part of this study will determine the involvement of neural pathways in powerful innate mechanisms of cardioprotection underlying the (pre)conditioning phenomena. The results of the proposed experiments are expected to have an instant translational potential and may lead to the development of novel therapeutic strategies which recruit innate neural mechanisms of cardioprotection to limit myocardial injury and improve quality of life of individuals suffering from heart disease. RESCUE THE HEART project includes an intense program of research and training to be undertaken by the experienced researcher and will ultimately promote effective transfer of research expertise, new technologies and research philosophy across wider European research base.

 Publications

year authors and title journal last update
List of publications.
2017 Fergus M O\'Farrell, Svetlana Mastitskaya, Matthew Hammond-Haley, Felipe Freitas, Wen Rui Wah, David Attwell
Capillary pericytes mediate coronary no-reflow after myocardial ischaemia
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.29280
eLife 6 2019-06-13
2016 Svetlana Mastitskaya, Marina Basalay, Patrick S. Hosford, Andrew G. Ramage, Andrey Gourine, Alexander V. Gourine
Identifying the Source of a Humoral Factor of Remote (Pre)Conditioning Cardioprotection
published pages: e0150108, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0150108
PLOS ONE 11/2 2019-06-13
2016 Marina V. Basalay, Svetlana Mastitskaya, Aleksander Mrochek, Gareth L. Ackland, Ana Gutierrez del Arroyo, Jenifer Sanchez, Per-Ove Sjoquist, John Pernow, Alexander V. Gourine, Andrey Gourine
Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning
published pages: 669-676, ISSN: 0008-6363, DOI: 10.1093/cvr/cvw216
Cardiovascular Research 112/3 2019-06-13
2017 Marina Basalay, Svetlana Mastitskaya, Aleksander Mrochek, Gareth L. Ackland, Ana Gutierrez del Arroyo, Jenifer Sanchez, Per-Ove Sjoquist, John Pernow, Alexander V. Gourine, Andrey Gourine
Reply: Glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning
published pages: 13.2-14, ISSN: 0008-6363, DOI: 10.1093/cvr/cvw238
Cardiovascular Research 113/1 2019-06-13

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The information about "RESCUE THE HEART" are provided by the European Opendata Portal: CORDIS opendata.

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