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RhomBioID

Molecular mechanisms of rhomboid-like proteins in human immunity

Total Cost €

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EC-Contrib. €

0

Partnership

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 RhomBioID project word cloud

Explore the words cloud of the RhomBioID project. It provides you a very rough idea of what is the project "RhomBioID" about.

traffics    mechanistic    conventional    fate    interactions    biochemical    ex    unclear    quasi    release    direct    degradation    intramembrane    candidates    validated    cellular    serine    contacts    secreted    confirm    regulates    area    mechanism    modulator    similarly    found    signalling    permeabilised    pseudoenzymes    interaction    protease    detergent    immune    track    trafficking    screen    assay    integrates    gamma    subsequent    regulation    eukaryotic    erad    rhbdl4    expressed    polytopic    relevance    biological    human    myeloid    cell    cells    soluble    secretory    significance    interferon    surface    relies    immunity    preliminary    macrophage    rhomboid    coordinates    tnf    vivo    irhom2    proteases    reported    rhomboids    tace    hypothesise    vital    threats    biology    family    networks    data    pseudoenzyme    little    interactors    macrophages    fundamental    organisms    context    maturation    bioid    inflammatory    physiological    regulate    plethora    health    er    proteins    stimuli   

Project "RhomBioID" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://users.path.ox.ac.uk/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-07   to  2017-04-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

The immune system coordinates vital responses against a plethora of threats. It relies on well-described signalling networks via soluble proteins and cell-to-cell contacts. The secretory pathway traffics all secreted and surface proteins, but the mechanism of how immune cells control this process is unclear. Rhomboid-like proteins are a family of polytopic intramembrane proteins serine proteases and pseudoenzymes found in all organisms. Most eukaryotic rhomboid-like proteins regulate the fate of proteins in the secretory pathway. The rhomboid protease RHBDL4 is reported to regulate ER associated degradation (ERAD). The rhomboid pseudoenzyme, iRhom2, is essential for the trafficking and maturation of TACE, and subsequent TNF release in response to inflammatory stimuli in myeloid cells. Little is understood about the mechanism of how these rhomboid-like proteins regulate trafficking. I hypothesise that RHBDL4 regulates signalling networks in myeloid cells, similarly to iRhom2. Indeed, according to my preliminary data, RHBDL4 and iRhom2 are both expressed in human myeloid cells, and are induced by interferon gamma, a modulator of signalling networks in immunity. In this project, I aim to provide cell biological and mechanistic insight into RHBDL4 and iRhom2 regulation of signalling networks in human immunity. I will identify new interactors of RHBDL4 and iRhom2 via a novel biochemical screen called BioID. Candidates will be validated using conventional cell biological methodologies and a new interaction assay called M-Track. I will confirm these interactions in a quasi-physiological context, using a human ex vivo macrophage system. The biological significance of the interactions will be studied using detergent-permeabilised cellular systems of human macrophages. My focus on human rhomboids and immunity integrates a very timely area of fundamental cell biology with a topic of direct relevance to human health.

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The information about "RHOMBIOID" are provided by the European Opendata Portal: CORDIS opendata.

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