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RhomBioID

Molecular mechanisms of rhomboid-like proteins in human immunity

Total Cost €

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EC-Contrib. €

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Partnership

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 RhomBioID project word cloud

Explore the words cloud of the RhomBioID project. It provides you a very rough idea of what is the project "RhomBioID" about.

data    regulate    modulator    area    contacts    rhomboid    coordinates    rhbdl4    eukaryotic    assay    candidates    surface    vital    detergent    relies    fundamental    biological    secreted    networks    regulates    track    gamma    proteins    pseudoenzyme    interactors    preliminary    intramembrane    tnf    family    interaction    threats    little    significance    ex    soluble    found    unclear    macrophage    erad    biology    traffics    interactions    rhomboids    integrates    mechanism    subsequent    stimuli    macrophages    quasi    context    conventional    proteases    interferon    signalling    immunity    inflammatory    validated    screen    human    tace    protease    cell    organisms    secretory    relevance    trafficking    polytopic    pseudoenzymes    serine    permeabilised    er    plethora    reported    similarly    fate    release    irhom2    maturation    hypothesise    mechanistic    myeloid    immune    degradation    expressed    health    biochemical    bioid    cells    physiological    vivo    cellular    regulation    confirm    direct   

Project "RhomBioID" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://users.path.ox.ac.uk/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-07   to  2017-04-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

The immune system coordinates vital responses against a plethora of threats. It relies on well-described signalling networks via soluble proteins and cell-to-cell contacts. The secretory pathway traffics all secreted and surface proteins, but the mechanism of how immune cells control this process is unclear. Rhomboid-like proteins are a family of polytopic intramembrane proteins serine proteases and pseudoenzymes found in all organisms. Most eukaryotic rhomboid-like proteins regulate the fate of proteins in the secretory pathway. The rhomboid protease RHBDL4 is reported to regulate ER associated degradation (ERAD). The rhomboid pseudoenzyme, iRhom2, is essential for the trafficking and maturation of TACE, and subsequent TNF release in response to inflammatory stimuli in myeloid cells. Little is understood about the mechanism of how these rhomboid-like proteins regulate trafficking. I hypothesise that RHBDL4 regulates signalling networks in myeloid cells, similarly to iRhom2. Indeed, according to my preliminary data, RHBDL4 and iRhom2 are both expressed in human myeloid cells, and are induced by interferon gamma, a modulator of signalling networks in immunity. In this project, I aim to provide cell biological and mechanistic insight into RHBDL4 and iRhom2 regulation of signalling networks in human immunity. I will identify new interactors of RHBDL4 and iRhom2 via a novel biochemical screen called BioID. Candidates will be validated using conventional cell biological methodologies and a new interaction assay called M-Track. I will confirm these interactions in a quasi-physiological context, using a human ex vivo macrophage system. The biological significance of the interactions will be studied using detergent-permeabilised cellular systems of human macrophages. My focus on human rhomboids and immunity integrates a very timely area of fundamental cell biology with a topic of direct relevance to human health.

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The information about "RHOMBIOID" are provided by the European Opendata Portal: CORDIS opendata.

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