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RhomBioID

Molecular mechanisms of rhomboid-like proteins in human immunity

Total Cost €

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EC-Contrib. €

0

Partnership

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 RhomBioID project word cloud

Explore the words cloud of the RhomBioID project. It provides you a very rough idea of what is the project "RhomBioID" about.

subsequent    permeabilised    ex    biochemical    regulate    modulator    relies    cell    threats    trafficking    screen    cells    signalling    protease    myeloid    quasi    secreted    proteases    pseudoenzyme    fundamental    contacts    surface    similarly    immunity    irhom2    preliminary    interactors    integrates    mechanistic    track    expressed    hypothesise    vivo    candidates    confirm    coordinates    conventional    health    er    macrophages    erad    physiological    stimuli    interaction    soluble    release    degradation    pseudoenzymes    found    little    direct    rhomboid    tace    cellular    validated    human    macrophage    networks    interferon    area    relevance    biology    gamma    eukaryotic    assay    context    intramembrane    rhbdl4    biological    plethora    significance    mechanism    bioid    interactions    detergent    secretory    inflammatory    immune    tnf    data    unclear    organisms    polytopic    vital    family    maturation    reported    fate    proteins    traffics    serine    regulation    rhomboids    regulates   

Project "RhomBioID" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://users.path.ox.ac.uk/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-07   to  2017-04-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

The immune system coordinates vital responses against a plethora of threats. It relies on well-described signalling networks via soluble proteins and cell-to-cell contacts. The secretory pathway traffics all secreted and surface proteins, but the mechanism of how immune cells control this process is unclear. Rhomboid-like proteins are a family of polytopic intramembrane proteins serine proteases and pseudoenzymes found in all organisms. Most eukaryotic rhomboid-like proteins regulate the fate of proteins in the secretory pathway. The rhomboid protease RHBDL4 is reported to regulate ER associated degradation (ERAD). The rhomboid pseudoenzyme, iRhom2, is essential for the trafficking and maturation of TACE, and subsequent TNF release in response to inflammatory stimuli in myeloid cells. Little is understood about the mechanism of how these rhomboid-like proteins regulate trafficking. I hypothesise that RHBDL4 regulates signalling networks in myeloid cells, similarly to iRhom2. Indeed, according to my preliminary data, RHBDL4 and iRhom2 are both expressed in human myeloid cells, and are induced by interferon gamma, a modulator of signalling networks in immunity. In this project, I aim to provide cell biological and mechanistic insight into RHBDL4 and iRhom2 regulation of signalling networks in human immunity. I will identify new interactors of RHBDL4 and iRhom2 via a novel biochemical screen called BioID. Candidates will be validated using conventional cell biological methodologies and a new interaction assay called M-Track. I will confirm these interactions in a quasi-physiological context, using a human ex vivo macrophage system. The biological significance of the interactions will be studied using detergent-permeabilised cellular systems of human macrophages. My focus on human rhomboids and immunity integrates a very timely area of fundamental cell biology with a topic of direct relevance to human health.

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The information about "RHOMBIOID" are provided by the European Opendata Portal: CORDIS opendata.

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