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TAXINOMISIS SIGNED

A multidisciplinary approach for the stratification of patients with carotid artery disease

Total Cost €

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EC-Contrib. €

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Partnership

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 TAXINOMISIS project word cloud

Explore the words cloud of the TAXINOMISIS project. It provides you a very rough idea of what is the project "TAXINOMISIS" about.

operations    chip    prospective    morbidity    surgical    reducing    risk    device    medication    trigger    biomarkers    disease    software    outcomes    nor    avenues    observational    assist    generation    imaging    criteria    model    artery    definition    90s    interventions    phenotypes    stratified    commercialization    era    solutions    therapeutic    erosion    versus    susceptibility    rationally    cohorts    patient    healthcare    symptomatic    longitudinal    regulatory    mortality    multilevel    prediction    dissection    medicine    evolution    endotypes    effectiveness    taxinomisis    omics    stroke    medical    mechanisms    rupture    stratification    mediating    clinical    refining    evaluation    pharmacogenomics    intervention    incorporating    molecular    missing    biotechnology    events    unnecessary    remarkably    worldwide    causes    identification    primary    treatment    protection    ethical    plaque    introduction    personalised    mechanism    decision    opening    carotid    personalized    patients    fingerprints    cerebrovascular    ischaemic    lab   

Project "TAXINOMISIS" data sheet

The following table provides information about the project.

Coordinator
PANEPISTIMIO IOANNINON 

Organization address
address: PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON
city: IOANNINA
postcode: 45110
website: www.uoi.gr / www.rc.uoi.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website https://taxinomisis-project.eu/
 Total cost 5˙999˙402 €
 EC max contribution 5˙999˙402 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2017-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PANEPISTIMIO IOANNINON EL (IOANNINA) coordinator 751˙375.00
2    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 816˙656.00
3    INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM BE (LEUVEN) participant 799˙558.00
4    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) participant 550˙312.00
5    ZORA BIOSCIENCES OY FI (ESPOO) participant 400˙000.00
6    PIRKANMAA HOSPITAL DISTRICT FI (TAMPERE) participant 396˙250.00
7    FACULTY OF MEDICINE, UNIVERSITY OF BELGRADE RS (BELGRADE) participant 350˙000.00
8    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 304˙000.00
9    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) participant 302˙500.00
10    ENGINEERING - INGEGNERIA INFORMATICA SPA IT (ROMA) participant 291˙250.00
11    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) participant 225˙000.00
12    IRCCS OSPEDALE POLICLINICO SAN MARTINO IT (GENOVA) participant 218˙750.00
13    STICHTING NEDERLANDS INSTITUUT VOOR ONDERZOEK VAN DE GEZONDHEIDSZORG NL (UTRECHT) participant 183˙750.00
14    ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO RS (KRAGUJEVAC) participant 181˙250.00
15    FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA ES (BARCELONA) participant 169˙375.00
16    EUROPEAN SOCIETY FOR CARDIOVASCULAR AND ENDOVASCULAR SURGERY CH (ZURICH) participant 59˙375.00
17    Fair Dynamics Consulting s.r.l. IT (Milano) participant 0.00

Map

 Project objective

Carotid artery disease, the primary trigger of ischaemic cerebrovascular events including stroke, causes major morbidity, mortality and healthcare costs worldwide. Still, treatment is based on criteria established in the 90s that do not take into account the molecular evolution we have witnessed since, nor the introduction of new medication, leading to remarkably high unnecessary surgical treatment while missing most patients at risk. TAXINOMISIS will provide novel disease mechanism-based stratification for carotid artery disease patients to address the needs for stratified and personalised therapeutic interventions in the current era. This will be achieved through (1) the dissection of mechanisms mediating carotid artery disease, and identification of susceptibility and protection factors of plaque erosion and/or rupture using longitudinal cohorts and multi-omics, (2) the definition of distinct disease phenotypes and endotypes, and generation of molecular fingerprints of high versus low-risk states through systems medicine, (3) the development of a multilevel risk prediction model of the symptomatic plaque incorporating new biomarkers and advanced imaging, implemented in a software, to assist patient stratification and clinical decision making, (4) the development of novel pharmacogenomics solutions based on lab-on-a-chip technology to support personalized treatment, (5) the evaluation of the new risk prediction model and lab-on-a-chip device in a prospective observational clinical study, and (6) the assessment of regulatory, cost-effectiveness and ethical issues towards the implementation and commercialization of the programme’s outcomes. TAXINOMISIS has therefore the potential to rationally change the current state-of-the-art in the stratification of patients with carotid artery disease by reducing unnecessary operations, refining medical treatment and opening up new avenues for therapeutic intervention, while strengthening the European biotechnology sector.

 Deliverables

List of deliverables.
Communication and dissemination activities v1 Documents, reports 2019-07-23 16:14:48
Project handbook, risk management and quality assurance plan Documents, reports 2019-07-22 16:48:55
First study subject approvals package Documents, reports 2019-06-19 12:08:48
Project presentation material Other 2019-06-19 12:08:48
Midterm recruitment report Documents, reports 2019-06-19 12:08:48

Take a look to the deliverables list in detail:  detailed list of TAXINOMISIS deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Djorovic Smiljana; Saveljic Igor; Filipovic Nenad
Computational modelling of carotid artery and simulation of plaque progression
published pages: , ISSN: , DOI: 10.5281/zenodo.3253189
2 2019-08-29
2019 Djorovic Smiljana; Saveljic Igor; Filipovic Nenad
Analysis of the carotid artery and atherosclerotic plaque growth using the patient-specific parameters
published pages: , ISSN: , DOI: 10.5281/zenodo.3253178
2 2019-08-29
2019 Djorovic Smiljana; Saveljic Igor; Filipovic Nenad
Carotid atherosclerosis disease: modelling and analysis of plaque development
published pages: , ISSN: , DOI: 10.5281/zenodo.3253204
2 2019-08-29
2019 Djorovic Smiljana; Saveljic Igor; Filipovic Nenad
Three-dimensional numerical analysis of atherosclerosis development within carotid artery
published pages: , ISSN: , DOI: 10.5281/zenodo.3253176
2 2019-08-29
2018 Tuukka Taipale, Ilkka Seppälä, Emma Raitoharju, Nina Mononen, Leo-Pekka Lyytikäinen, Thomas Illig, Melanie Waldenberger, Markus Juonala, Nina Hutri-Kähönen, Niku Oksala, Mika Kähönen, Olli Raitakari, Terho Lehtimäki
Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28563-y
Scientific Reports 8/1 2019-08-29
2019 Vassiliki T. Potsika, Michalis D. Mantzaris, Panagiotis K. Siogkas, Ioannis G. Pappas, Themis P. Exarchos, Dimitrios I. Fotiadis
A Multilevel Approach to Evaluate Numerically Plaque Progression in Carotid Artery Disease
published pages: , ISSN: , DOI: 10.5281/zenodo.3250568
8th Panhellenic Congress of Biomedical Technology 1 2019-08-29
2019 Michalis D. Mantzaris, Vassiliki T. Potsika, Panagiotis K. Siogkas, Ioannis G. Pappas, Themis P. Exarchos, Member, IEEE, Igor B. Koncar, Jaroslav Pelisek, Evangelos Andreakos and Dimitrios I. Fotiadis
Computational modeling and big data approaches for the stratification of carotid artery disease
published pages: , ISSN: , DOI: 10.5281/zenodo.3250574
Computational modeling and big data approaches for the stratification of carotid artery disease 1 2019-08-29
2018 Pashupati P. Mishra Leo-Pekka Lyytikäinen Mika Kähönen Olli T. Raitakari Reijo Laaksonen Terho Lehtimäki
Ceramides improve prediction accuracy of subclinical atherosclerosis
published pages: , ISSN: , DOI: 10.5281/zenodo.3250838
European Conference on Computational Biology 2018 2019-08-29
2019 Pashupati P. Mishra Leo-Pekka Lyytikäinen Binisha H. Mishra Mika Kähönen Olli T. Raitakari Reijo Laaksonen Terho Lehtimäki
Lipidome improves predictive ability of subclinical atherosclerosis over traditional risk factors: The Cardiovascular Risk in Young Finns Study
published pages: , ISSN: , DOI: 10.5281/zenodo.3250843
15th Annual conference of the Metabolomics Society 2019-08-29

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