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The cardiovascular consequences of endurance exercise

Total Cost €


EC-Contrib. €






Project "CARDI-ACHE" data sheet

The following table provides information about the project.


Organization address
postcode: L3 5UX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Problem: Exercise training represents an attractive and low-cost strategy to improve cardiovascular health. Recent studies, however, report novel evidence that endurance exercise can lead to potentially detrimental cardiac maladaptations. First, acute exercise-induced elevations in cardiac troponin (cTn) levels have been found, which typically reflect myocardial (micro-)damage and are predictive of future cardiovascular events and mortality. Secondly, myocardial fibrosis has been reported in 12–50% of individuals engaged in lifelong exercise training, reflecting scarring of cardiac tissue that is typically found in patients with cardiovascular diseases (CVD). These cardiac maladaptations are highly unexpected and largely unexplained in apparently healthy individuals.

CARDI-ACHE: Based on the latest scientific insights, the overall aim of this proposal is to elucidate the clinical importance of exercise-induced cTn elevations and myocardial fibrosis in endurance athletes. Better understanding of the clinical relevance of these adaptations is important to differentiate between the beneficial and the potentially harmful effects of exercise. Accordingly, I will study the following scientifically and clinically relevant questions: I. What is the prognostic value of exercise-induced cTn elevations? II. What are the functional consequences of myocardial fibrosis and are these mediated by lifelong physical activity? III. Do exercise-induced cTn elevations contribute to the development of myocardial fibrosis?

Relevance for science & candidate. With this project, I will use the most technologically advanced approaches and tools to understand the clinical relevance of potential cardiac maladaptations to exercise training. The studies are performed in a world-renowned research group which allows me to expand my expertise in exercise cardiology using state-of-the-art facilities.


year authors and title journal last update
List of publications.
2017 Thijs M.H. Eijsvogels, Martijn F.H. Maessen
Exercise for Coronary Heart Disease Patients
published pages: 1701-1703, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2017.08.016
Journal of the American College of Cardiology 70/14 2019-06-17
2017 Martijn F.H. Maessen, Casper G. Schalkwijk, Rebecca J.H.M. Verheggen, Vincent L. Aengevaeren, Maria T.E. Hopman, Thijs M.H. Eijsvogels
A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls
published pages: 921-926, ISSN: 1440-2440, DOI: 10.1016/j.jsams.2017.03.011
Journal of Science and Medicine in Sport 20/10 2019-06-17
2016 Nathalie MM Benda, Maria TE Hopman, Arie PJ van Dijk, David Oxborough, Keith P George, Dick HJ Thijssen, Thijs MH Eijsvogels
Impact of prolonged walking exercise on cardiac structure and function in cardiac patients versus healthy controls
published pages: 1252-1260, ISSN: 2047-4873, DOI: 10.1177/2047487316631389
European Journal of Preventive Cardiology 23/12 2019-06-17
2017 Vincent L. Aengevaeren, Arend Mosterd, Thijs L. Braber, Niek H.J. Prakken, Pieter A. Doevendans, Diederick E. Grobbee, Paul D. Thompson, Thijs M.H. Eijsvogels, Birgitta K. Velthuis
Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in AthletesClinical Perspective
published pages: 138-148, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.117.027834
Circulation 136/2 2019-06-17
2016 Vincent L. Aengevaeren, Maria T. E. Hopman, Thijs M. H. Eijsvogels
Fitness and Coronary Artery Calcification
published pages: 716, ISSN: 2168-6106, DOI: 10.1001/jamainternmed.2016.0898
JAMA Internal Medicine 176/5 2019-06-17
2017 Vincent L. Aengevaeren, Maria T.E. Hopman, Dick H.J. Thijssen, Roland R. van Kimmenade, Menko-Jan de Boer, Thijs M.H. Eijsvogels
Endurance exercise-induced changes in BNP concentrations in cardiovascular patients versus healthy controls
published pages: 430-435, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2016.11.016
International Journal of Cardiology 227 2019-06-17
2017 Martijn F.H. Maessen, Thijs M.H. Eijsvogels, Ayla Grotens, Maria T.E. Hopman, Dick H.J. Thijssen, Hendrik H.G. Hansen
Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls
published pages: , ISSN: 1476-7120, DOI: 10.1186/s12947-017-0104-9
Cardiovascular Ultrasound 15/1 2019-06-17
2016 Thijs M. H. Eijsvogels, Paul D. Thompson
Exercise Intensity, Dose, and Cardiovascular Disease—Reply
published pages: 1659, ISSN: 0098-7484, DOI: 10.1001/jama.2016.0312
JAMA 315/15 2019-06-17
2016 Freek R. van de Schoor, Vincent L. Aengevaeren, Maria T.E. Hopman, David L. Oxborough, Keith P. George, Paul D. Thompson, Thijs M.H. Eijsvogels
Myocardial Fibrosis in Athletes
published pages: 1617-1631, ISSN: 0025-6196, DOI: 10.1016/j.mayocp.2016.07.012
Mayo Clinic Proceedings 91/11 2019-06-17
2015 Martijn F.H. Maessen, Maria T.E. Hopman, André L.M. Verbeek, Thijs M.H. Eijsvogels
Dose of Jogging
published pages: 2672-2673, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2015.02.080
Journal of the American College of Cardiology 65/24 2019-06-17
2017 Esmée A. Bakker, Silvie Timmers, Maria T. E. Hopman, Paul D. Thompson, André L. M. Verbeek, Thijs M. H. Eijsvogels
Association Between Statin Use and Prevalence of Exercise-Related Injuries: A Cross-Sectional Survey of Amateur Runners in the Netherlands
published pages: 1885-1892, ISSN: 0112-1642, DOI: 10.1007/s40279-017-0681-7
Sports Medicine 47/9 2019-06-17
2017 Thijs M. Eijsvogels, Paul D. Thompson
Are There Clinical Cardiac Complications From Too Much Exercise?
published pages: 9-11, ISSN: 1537-890X, DOI: 10.1249/JSR.0000000000000322
Current Sports Medicine Reports 16/1 2019-06-17
2016 Martijn F.H. Maessen, André L.M. Verbeek, Esmée A. Bakker, Paul D. Thompson, Maria T.E. Hopman, Thijs M.H. Eijsvogels
Lifelong Exercise Patterns and Cardiovascular Health
published pages: 745-754, ISSN: 0025-6196, DOI: 10.1016/j.mayocp.2016.02.028
Mayo Clinic Proceedings 91/6 2019-06-17
2016 Paul D. Thompson, Silvana Molossi, Duck-chul Lee, Michael S. Emery, Thijs M.H. Eijsvogels
published pages: 2911, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.03.574
Journal of the American College of Cardiology 67/24 2019-06-17
Vascular Function and Structure in Veteran Athletes after Myocardial Infarction
published pages: 21-28, ISSN: 0195-9131, DOI: 10.1249/MSS.0000000000001075
Medicine & Science in Sports & Exercise 49/1 2019-06-17
2017 Esmée A. Bakker, Duck-chul Lee, Xuemei Sui, Enrique G. Artero, Jonatan R. Ruiz, Thijs M.H. Eijsvogels, Carl J. Lavie, Steven N. Blair
Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome
published pages: 1214-1222, ISSN: 0025-6196, DOI: 10.1016/j.mayocp.2017.02.018
Mayo Clinic Proceedings 92/8 2019-06-17
2017 Martijn F. H. Maessen, Anke C. C. M. van Mil, Yaïra Straathof, Niels P. Riksen, Gerard A. P. J. M. Rongen, Maria T. E. Hopman, Thijs M. H. Eijsvogels, Dick H. J. Thijssen
Impact of lifelong exercise training on endothelial ischemia-reperfusion and ischemic preconditioning in humans
published pages: R828-R834, ISSN: 0363-6119, DOI: 10.1152/ajpregu.00466.2016
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 312/5 2019-06-17
2018 Esmée A. Bakker, Johan A. Snoek, Esther P. Meindersma, Maria T.E. Hopman, Louise Bellersen, André L.M. Verbeek, Dick H.J. Thijssen, Thijs M.H. Eijsvogels
Absence of Fitness Improvement Is Associated with Outcomes in Heart Failure Patients
published pages: 1, ISSN: 0195-9131, DOI: 10.1249/MSS.0000000000001429
Medicine & Science in Sports & Exercise 2019-06-17
2016 Thijs M.H. Eijsvogels, Silvana Molossi, Duck-chul Lee, Michael S. Emery, Paul D. Thompson
Exercise at the Extremes
published pages: 316-329, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2015.11.034
Journal of the American College of Cardiology 67/3 2019-06-17
2017 Thijs M. H. Eijsvogels, David L. Oxborough, Rory O’Hanlon, Sanjay Sharma, Sanjay Prasad, Greg Whyte, Keith P. George, Mathew G. Wilson
Global and regional cardiac function in lifelong endurance athletes with and without myocardial fibrosis
published pages: 1297-1303, ISSN: 1746-1391, DOI: 10.1080/17461391.2017.1373864
European Journal of Sport Science 17/10 2019-06-17
2016 Thijs M.H. Eijsvogels, Keith P. George, Paul D. Thompson
Cardiovascular benefits and risks across the physical activity continuum
published pages: 566-571, ISSN: 0268-4705, DOI: 10.1097/HCO.0000000000000321
Current Opinion in Cardiology 31/5 2019-06-17
2017 Martijn FH Maessen, Thijs MH Eijsvogels, Guus Stevens, Arie PJ van Dijk, Maria TE Hopman
Benefits of lifelong exercise training on left ventricular function after myocardial infarction
published pages: 1856-1866, ISSN: 2047-4873, DOI: 10.1177/2047487317728765
European Journal of Preventive Cardiology 24/17 2019-06-17

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