Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. b-lactams c-h activation

b-lactams C-H activation

Discovery of novel β-lactam analogs oriented to control multidrug-resistant bacteria enabled by Pd-catalyzed C–H activation of aliphatic amines

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 b-lactams C-H activation project word cloud

Explore the words cloud of the b-lactams C-H activation project. It provides you a very rough idea of what is the project "b-lactams C-H activation" about.

bonds    biotechnology    expand    starting    dept    either    lactams    conversion    uncovered    ley    activation    resistant    bioactivity    consideration    rest    catalysed    amines    spectrometry    mass    professor    flow    synthetic    university    synthesize    professors    steve    stagnating    mode    analogs    tools    lapkin    ing    screen    evaluation    microorganisms    first    readily    caused    complexity    antibiotics    chemical    employed    beta    euros    scaffolds    alexei    functional    synthesis    lactam    platform    groups    metal    david    pace    parallel    relying    variety    25    infections    relies    billions    reaction    plethora    convert    chemistry    engineering    hindered    throughput    spring    building    mostly    functionalize    dramatically    antibiotic    cambridge    sultam    shockingly    standard    substituted    cyclic    scope    transformation    deaths    bacteria    multidrug    tool    gaunt    expenses    world    secondary    acyclic    reactivity    versatile    discovered    directing   

Project "b-lactams C-H activation" data sheet

The following table provides information about the project.

Coordinator		 THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://www-gaunt.ch.cam.ac.uk/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

Map

 Project objective

In Europe, infections caused by multidrug-resistant bacteria lead to more than 25,000 deaths and expenses of billions of euros per year. These numbers dramatically increase when the rest of the world is taken into consideration. Shockingly, the pace of production of new antibiotics to control such microorganisms is stagnating. Therefore, developing new synthetic tools that enable the synthesis of scaffolds with potential antibiotic properties is crucial. Metal catalysed C–H activation represents a versatile tool for building chemical complexity. It mostly relies on directing functional groups to functionalize C–H bonds. Recently, Professor Gaunt at the University of Cambridge has uncovered a new C–H activation mode that enables the conversion of hindered amines into β-lactams. The first aim of this project is to develop this new reactivity mode into a versatile transformation that is able to convert a variety of cyclic and acyclic amines into substituted β-lactam scaffolds. To accomplish this goal, a multi parallel platform based on mass spectrometry, relying either on standard high-throughput procedures or flow chemistry, will be implemented and used to screen a large number of conditions to expand the scope of this new pathway for β-lactams. The flow chemistry system for reaction evaluation will be design in collaboration with Professors Alexei Lapkin (Dept. Chemical Engineering and Biotechnology) and Steve Ley (Chemistry Dept.) from the University of Cambridge. The readily discovered new conditions for C–H activation will then be employed to synthesize a plethora of β-lactams and β-sultam analogs starting from simple secondary amines. Finally, in collaboration with Professor David Spring (Chemistry Dept. University of Cambridge), the bioactivity of the resulting scaffolds will be evaluated against multidrug-resistant bacteria.

 Publications

year authors and title journal last update
List of publications.
2017 Matthew James Gaunt, Jaime Cabrera-Pardo, Aaron Trowbridge, Manuel Nappi, Kyohei Ozaki
Selective Pd(II)-Catalyzed Carbonylation of Methylene beta-C-H Bonds in Aliphatic Amines
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201706303 		Angewandte Chemie International Edition 2019-07-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "B-LACTAMS C-H ACTIVATION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "B-LACTAMS C-H ACTIVATION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

STRESS-Mums (2019)

Study on TRansition and Exclusion in Society of Single-Mums

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More