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MecaMorphEME SIGNED

Four-dimensional physical modeling and numerical simulation of the early mouse embryo morphogenesis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MecaMorphEME project word cloud

Explore the words cloud of the MecaMorphEME project. It provides you a very rough idea of what is the project "MecaMorphEME" about.

forces    ultimately    outside    principles    dynamics    regulation    quantitative    proteins    experimental    physical    theoretical    dimensional    expert    designed    precise    reveals    imaging    shell    model    largely    accurately    molecular    unknown    segregated    divisions    cell    internalization    interface    group    cortical    integrating    cycles    active    refined    biophysical    incorporate    governing    mouse    actomyosin    4d    surface    adhesion    contractile    reproductive    rearrangements    16    morphogenesis    mechanism    primarily    lineages    regulated    medicine    accurate    embryos    organize    intense    interdisciplinary    characterization    progress    inside    cells    mechanisms    modeling    validations    mammalian    description    self    embryo    lacks    theories    shapes    biology    dynamic    deformations    crosstalk    layers    developmental    measured    close    biochemical    cortex    transition    specification    framework    shape    mechanical    uncover    succession    predictions   

Project "MecaMorphEME" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.virtual-embryo.com/
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 171˙460.00

Map

 Project objective

The quantitative understanding of the early development of mammalian embryos is essential to the progress of reproductive medicine. Yet, the physical and mechanical principles governing their morphogenesis remain largely unknown. Early mouse embryos self-organize by a succession of cell divisions, deformations and rearrangements, leading ultimately to the specification of two distinct cell lineages, segregated in inside and outside layers. Mechanical forces are therefore as important as biochemical activity in this process and precise 4-dimensional imaging of cells within the embryo reveals intense surface dynamics, regulated by contractile and adhesion proteins. However, our understanding of early embryos development still lacks a precise physical model integrating a dynamic description of the mechanical forces controlling cell shape and cell-cell adhesion.

I will design a 4D physical model of the early mouse embryo providing accurate cell dynamics predictions. Cell shapes are primarily controlled by the actomyosin cortex and they will be described using recently developed cortical active shell theories. To represent accurately cell-cell adhesion dynamics, I will consider the crosstalk between cortical and adhesion proteins activities. Importantly, this model will be designed in close collaboration with an experimental group expert in the biophysical characterization of the mouse embryo, to incorporate measured mechanical parameters and molecular regulation mechanisms. Our model will be refined through cycles of theoretical predictions and experimental validations to uncover the principles of early mammalian embryos development and, more specifically, the mechanism of cell internalization at the 8 to 16 cells transition. This interdisciplinary project, at the interface between physical modeling and developmental biology will provide a unique and accurate biophysical framework for understanding the morphogenesis of early mammalian embryos.

 Publications

year authors and title journal last update
List of publications.
2016 Jean-Léon Maître, Hervé Turlier, Rukshala Illukkumbura, Björn Eismann, Ritsuya Niwayama, François Nédélec, Takashi Hiiragi
Asymmetric division of contractile domains couples cell positioning and fate specification
published pages: 344-348, ISSN: 0028-0836, DOI: 10.1038/nature18958
Nature 536/7616 2019-06-13

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