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MecaMorphEME SIGNED

Four-dimensional physical modeling and numerical simulation of the early mouse embryo morphogenesis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MecaMorphEME project word cloud

Explore the words cloud of the MecaMorphEME project. It provides you a very rough idea of what is the project "MecaMorphEME" about.

divisions    experimental    governing    morphogenesis    integrating    mechanisms    inside    cortex    embryo    quantitative    cell    designed    rearrangements    lacks    actomyosin    measured    lineages    theories    framework    physical    molecular    forces    largely    predictions    16    theoretical    validations    unknown    principles    imaging    deformations    cortical    primarily    transition    interdisciplinary    incorporate    characterization    ultimately    biophysical    dimensional    proteins    accurate    internalization    cells    reproductive    mouse    cycles    specification    expert    dynamic    biochemical    description    biology    intense    mechanism    regulated    crosstalk    adhesion    model    close    progress    outside    interface    active    shell    4d    dynamics    medicine    succession    modeling    contractile    mechanical    shape    mammalian    self    regulation    developmental    layers    embryos    refined    organize    group    surface    segregated    uncover    accurately    reveals    shapes    precise   

Project "MecaMorphEME" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.virtual-embryo.com/
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 171˙460.00

Map

 Project objective

The quantitative understanding of the early development of mammalian embryos is essential to the progress of reproductive medicine. Yet, the physical and mechanical principles governing their morphogenesis remain largely unknown. Early mouse embryos self-organize by a succession of cell divisions, deformations and rearrangements, leading ultimately to the specification of two distinct cell lineages, segregated in inside and outside layers. Mechanical forces are therefore as important as biochemical activity in this process and precise 4-dimensional imaging of cells within the embryo reveals intense surface dynamics, regulated by contractile and adhesion proteins. However, our understanding of early embryos development still lacks a precise physical model integrating a dynamic description of the mechanical forces controlling cell shape and cell-cell adhesion.

I will design a 4D physical model of the early mouse embryo providing accurate cell dynamics predictions. Cell shapes are primarily controlled by the actomyosin cortex and they will be described using recently developed cortical active shell theories. To represent accurately cell-cell adhesion dynamics, I will consider the crosstalk between cortical and adhesion proteins activities. Importantly, this model will be designed in close collaboration with an experimental group expert in the biophysical characterization of the mouse embryo, to incorporate measured mechanical parameters and molecular regulation mechanisms. Our model will be refined through cycles of theoretical predictions and experimental validations to uncover the principles of early mammalian embryos development and, more specifically, the mechanism of cell internalization at the 8 to 16 cells transition. This interdisciplinary project, at the interface between physical modeling and developmental biology will provide a unique and accurate biophysical framework for understanding the morphogenesis of early mammalian embryos.

 Publications

year authors and title journal last update
List of publications.
2016 Jean-Léon Maître, Hervé Turlier, Rukshala Illukkumbura, Björn Eismann, Ritsuya Niwayama, François Nédélec, Takashi Hiiragi
Asymmetric division of contractile domains couples cell positioning and fate specification
published pages: 344-348, ISSN: 0028-0836, DOI: 10.1038/nature18958
Nature 536/7616 2019-06-13

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