Opendata, web and dolomites

PROVEC SIGNED

Promoting Osteogenesis through Vascular Endothelial Cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PROVEC project word cloud

Explore the words cloud of the PROVEC project. It provides you a very rough idea of what is the project "PROVEC" about.

diseases    therapeutic    aging    single    cells    found    vasculature    completion    form    cultured    heterogeneity    models    mineral    computational    seq    capillaries    monitored    osteoporosis    cell    genetic    cultures    thereby    alone    regenerating    vascular    induce    osteoblast    generate    euros    signaling    manipulation    million    healthy    organoid    trigger    specialization    generates    regulation    microscopy    skeletal    hypoxia    ct    pharmacological    mapping    mouse    27    annual    organization    expansion    endothelial    sufficient    modulation    notch    patients    crosstalk    animal    imaging    beneficial    bone    endowed    disease    diseased    osteoblasts    billion    animals    appropriate    expression    gene    photon    37    combination    provec    confocal    ambitions    insights    human    functional    inducible    osteoprogenitors    osteoclasts    regeneration    biology    transplantation    powerful    ecs    living    health    rna    lineage    lack    fate    3d    preclinical    relevance    genetics    systemically    successful    sequencing    density    subpopulations    treatments    fundamental    mice    micro   

Project "PROVEC" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙205˙875 €
 EC max contribution 2˙205˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙205˙875.00

Map

 Project objective

The skeletal system and its vasculature form a functional unit with great relevance in health, regeneration, and disease. Our recent work has provided fundamental insights into the organization of the bone vasculature in mouse, its changes during aging, the heterogeneity and functional specialization of bone capillaries and endothelial cells, the regulation of these properties by Notch and hypoxia-inducible factor signaling, and the crosstalk with osteoblast lineage cells. Most importantly, we found that the manipulation of ECs in the aging animal can trigger the expansion of osteoprogenitors and thereby induce bone formation. PROVEC will now systemically identify and characterize endothelial cell subpopulations, their gene expression and functional properties in the healthy, aging, diseased and regenerating skeletal system. Preclinical models will establish whether endothelial cells are involved in the response to therapeutic treatments aiming at osteoblasts or osteoclasts, or if the modulation of ECs alone is sufficient to generate beneficial effects. Finally, PROVEC will investigate whether cultured mouse and human ECs can be endowed with beneficial properties to enhance bone formation in 3D organoid cultures and after transplantation into mice, which will be monitored by imaging in living animals. To achieve its ambitions aims, PROVEC will use a powerful combination of mouse genetics, disease models, genetic fate mapping, RNA-seq and single cell sequencing, computational biology, confocal and 2-photon microscopy, micro-CT imaging, pharmacological treatments, and cell biology methods to establish if and how vascular endothelial cells can be used to increase bone mineral density in preclinical models. The successful completion of PROVEC would be highly relevant for diseases such as osteoporosis, which affects around 27.5 million patients in the EU, generates annual costs of about 37 billion Euros, and for which we currently lack appropriate treatments.

 Publications

year authors and title journal last update
List of publications.
2020 Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams
YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.50770
eLife 9 2020-02-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PROVEC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PROVEC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More