Explore the words cloud of the metaC-Hfunct project. It provides you a very rough idea of what is the project "metaC-Hfunct" about.
The following table provides information about the project.
Coordinator |
THE UNIVERSITY OF MANCHESTER
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Total cost | 183˙454 € |
EC max contribution | 183˙454 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2014 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2015 |
Duration (year-month-day) | from 2015-04-01 to 2017-03-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | THE UNIVERSITY OF MANCHESTER | UK (MANCHESTER) | coordinator | 183˙454.00 |
The development of methods for the transition metal-catalysed functionalization of C-H bonds is revolutionizing synthetic organic chemistry by providing tools to simplify and accelerate the synthesis and modification of a myriad of known and still unknown organic molecules including aromatic compounds. However, in these processes, the ability to discriminate between C-H bonds for subsequent transformation into other functional groups still remains as a major challenge. To date, much progress has been made on developing strategies for the ortho-functionalization of arenes, mainly through the derivatization of the substrates with directing groups. meta-Functionalization approaches, on the other hand, are extremely scarce despite eta-substitution is a widespread motive amongst biologically active molecules. The research outlined in this proposal aims at developing a process that makes use of CO2 as an invisible directing group leading to an array of novel direct meta-functionalization methodologies. To do so, we envision a one-pot strategy involving a carboxylation ortho to an R group followed by a tandem CO2H directed ortho-functionalization/decarboxylation process that affords the desired meta-functionalized products and releases again the CO2 employed as the directing group. The realisation of the objectives of this project will push forward the state-of-the art in the area of C-H bond activation by providing step economical access to molecules that are difficult to prepare via conventional multistep routes.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Marc Font, Jacob Quibell, Greg Perry, Igor Larrosa The use of carboxylic acids as traceless directing groups for regioselective C–H bond functionalisation published pages: 5584-5597, ISSN: 1359-7345, DOI: 10.1039/C7CC01755C |
Chem. Commun. | 2019-07-23 |
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The information about "METAC-HFUNCT" are provided by the European Opendata Portal: CORDIS opendata.
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