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BIOeSPUN scaffolds

Bioactive glass in electrospun matrices: functionalised smart scaffolds for interface tissue engineering applications

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BIOeSPUN scaffolds" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG 

Organization address
address: SCHLOSSPLATZ 4
city: ERLANGEN
postcode: 91054
website: www.uni-erlangen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.biomat.techfak.uni-erlangen.de/mitarbeiter/bio-materialien/liliana-liverani.shtml
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG DE (ERLANGEN) coordinator 159˙460.00

Map

 Project objective

The project aims to fabricate and characterise novel type of multilayered scaffolds suitable for interface tissue engineering applications, in particular for osteochondral segment regeneration. Osteochondral defects imply injury in cartilage, bone and bone-cartilage interface tissues, characteristic of all the joints of human body, its causes could be both traumatic and due to aging-related pathologies. The project will be focused on the integration of several scaffold fabrication techniques for the development of novel electrospun multilayered scaffolds. In particular, considering the well-known effects of bioactive glass on osteogenesis, angiogenesis and its antibacterial activity, electrospun bioactive glass mats will be fabricated. Moreover, bioactive glass particles will be dispersed in a polymeric solution before the electrospinning for the fabrication of bioactive glass-doped mats. These two kind of scaffold will be used for the fabrication of the multilayered structures. Innovative solutions will be adopted for the obtainment of the stratified samples, integrating different technologies as the electrospinning, freeze-drying and foam replica method. The training of the researcher in the host Institution will be focus on the development of skills related to cell culture management and in particular on cell culture for tissue engineering. The training will start with cell viability tests and cell seeding on several kind of scaffolds. Several cell lines will be used and it will be also investigated stem cells differentiation. The use of co-culture systems and dynamic cell culture will also be evaluated and eventually applied to the multilayered scaffolds. An innovative approach will be used in the investigation of scaffold mechanical properties, in fact mechanical tests will be performed on the multilayered samples and on each single layer to evaluate the deposition of ECM on the seeded scaffolds and how it affects scaffold mechanical properties.

 Publications

year authors and title journal last update
List of publications.
2016 Liverani Liliana, Boccaccini Aldo
Electrospinning with benign solvents: feasibility study and versatile use of poly(epsilon-caprolactone) fibers
published pages: , ISSN: 2296-4185, DOI: 10.3389/conf.FBIOE.2016.01.01826
Frontiers in Bioengineering and Biotechnology 4 2019-07-23
2017 L. Liverani, J.A. Roether, A.R. Boccaccini
Nanofiber composites in bone tissue engineering. In: Nanofiber Composite Materials for Biomedical Applications edited by Murugan Ramalingam and Seeram Ramakrishna.
published pages: 301-323, ISSN: , DOI: 10.1016/B978-0-08-100173-8.00012-0
2019-07-23
2016 Liliana Liverani, Aldo Boccaccini
Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents
published pages: 75, ISSN: 2079-4991, DOI: 10.3390/nano6040075
Nanomaterials 6/4 2019-07-23
2016 William C. Lepry, Sophia Smith, Liliana Liverani, Aldo R. Boccaccini, Showan N. Nazhat
Acellular Bioactivity of Sol-Gel Derived Borate Glass-Polycaprolactone Electrospun Scaffolds
published pages: , ISSN: 2299-3932, DOI: 10.1515/bglass-2016-0011
Biomedical glasses 2/1 2019-07-23
2017 Liliana Liverani, Jonas Lacina, Judith A. Roether, Elena Boccardi, Manuela S. Killian, Patrik Schmuki, Dirk W. Schubert, Aldo R. Boccaccini
Incorporation of bioactive glass nanoparticles in electrospun PCL/chitosan fibers by using benign solvents
published pages: , ISSN: 2452-199X, DOI: 10.1016/j.bioactmat.2017.05.003
Bioactive Materials 2019-07-23

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The information about "BIOESPUN SCAFFOLDS" are provided by the European Opendata Portal: CORDIS opendata.

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