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CONFINES

Controlling Cell Fate through Smart Nanoheaters

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CONFINES project word cloud

Explore the words cloud of the CONFINES project. It provides you a very rough idea of what is the project "CONFINES" about.

induce    death    ligands    confines    smart    technological    selective    nanomaterial    combining    biology    nanovector    mode    cells    medicine    magnetic    tool    dual    view    tailor    bioengineered    forefront    physical    conceived    skills    fashion    ablation    characterization    space    nanownt    expertise    polarity    orchestrates    activate    molecular    central    thermal    translational    signalling    hyperthermia    time    chemico    vitro    nanoheater    complete    shape    breakthrough    complement    contexts    basic    synthetic    holds    invertebratehydra    vivo    nanoparticles    proof    promises    nanovectorable    mediated    uniquenanovector    heat    activator    nanobiotechnology    demand    downstream    govern    mechanisms    human    wnt    canonical    synthesis    cultures    point    cell    functionalisation    operate    intriguing    inactive    vulgaris    validate    fascinating    receiving    owing    fate    diverse    cellular    achieving    exposure    aquatic    proliferation    stem    multidisciplinarytraining   

Project "CONFINES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE ZARAGOZA 

Organization address
address: CALLE PEDRO CERBUNA 12
city: ZARAGOZA
postcode: 50009
website: www.unizar.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://bionanosurf.unizar.es/projects/confines-h2020-msca-if-2014/
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2018-09-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 170˙121.00

Map

 Project objective

Achieving the control of cellular processes is one of the most intriguing challenges in cell biology and medicine. Forefront approaches based on bioengineered nanoparticles might have the potential to target specific cell pathways, thus controlling downstream cell activities in a space and time selective fashion. The present project aims to develop and to validate a smart nanovectorable to activate a specific cell signalling and, on demand, to induce heat mediated cell death of nanovector targeted cells. As proof of concept, CONFINES is conceived to target the Wnt canonical pathway, one of the most studied and fascinating cell signalling, which orchestrates central mechanisms that govern cell proliferation, polarity and stem cell fate. To achieve the proposed objectives, a controlled synthetic approach will tailor Wnt ligands on magnetic nanoparticles, combining targeting and magnetic properties in a uniquenanovector. Owing to its chemico-physical features, NanoWnt will enable complete control of the cell signalling, and it will operate in vitro (human cell cultures) and in vivo (the aquatic invertebrateHydra vulgaris), in a dual mode: i) as an activator of the canonical Wnt pathway in those contexts where it is inactive ii) or upon exposure to a magnetic field, as a nanoheater, enabling specific cell ablation by hyperthermia. From a technological point of view, the project will advance basic knowledge on thermal ablation (via magnetic hyperthermia) and holds promises for translational medicine, providing a breakthrough tool to shape cell fate of nanovector receiving cells. Furthermore, combining diverse expertise, CONFINES will offer the applicant advanced and multidisciplinarytraining in the field of nanomaterial synthesis, characterization and functionalisation as well as in hyperthermia technology, which will complement his current skills based on nanobiotechnology and cellular/molecular biology.

 Publications

year authors and title journal last update
List of publications.
2017 Rafael Martín-Rapun, Laura De Matteis, Alfredo Ambrosone, Sonia Garcia-Embid, Lucia Gutierrez, Jesus M. de la Fuente
Targeted Nanoparticles for the Treatment of Alzheimer\'s Disease
published pages: 1927-1952, ISSN: 1381-6128, DOI: 10.2174/1381612822666161226151011
Current Pharmaceutical Design 23/13 2019-06-13

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