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CONFINES

Controlling Cell Fate through Smart Nanoheaters

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CONFINES project word cloud

Explore the words cloud of the CONFINES project. It provides you a very rough idea of what is the project "CONFINES" about.

uniquenanovector    canonical    dual    govern    human    wnt    nanoheater    heat    vitro    molecular    ablation    biology    multidisciplinarytraining    confines    owing    inactive    intriguing    cell    signalling    cells    nanownt    fascinating    invertebratehydra    fashion    achieving    tool    holds    proliferation    technological    thermal    synthesis    nanobiotechnology    central    magnetic    characterization    shape    nanovectorable    space    expertise    exposure    breakthrough    vivo    combining    activate    nanomaterial    functionalisation    activator    cultures    induce    skills    mechanisms    time    promises    cellular    fate    basic    death    diverse    translational    nanoparticles    proof    point    operate    validate    synthetic    mediated    aquatic    vulgaris    mode    medicine    bioengineered    contexts    complement    view    polarity    ligands    selective    nanovector    smart    complete    receiving    downstream    forefront    stem    hyperthermia    conceived    demand    orchestrates    physical    tailor    chemico   

Project "CONFINES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE ZARAGOZA 

Organization address
address: CALLE PEDRO CERBUNA 12
city: ZARAGOZA
postcode: 50009
website: www.unizar.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://bionanosurf.unizar.es/projects/confines-h2020-msca-if-2014/
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2018-09-09

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 170˙121.00

Map

 Project objective

Achieving the control of cellular processes is one of the most intriguing challenges in cell biology and medicine. Forefront approaches based on bioengineered nanoparticles might have the potential to target specific cell pathways, thus controlling downstream cell activities in a space and time selective fashion. The present project aims to develop and to validate a smart nanovectorable to activate a specific cell signalling and, on demand, to induce heat mediated cell death of nanovector targeted cells. As proof of concept, CONFINES is conceived to target the Wnt canonical pathway, one of the most studied and fascinating cell signalling, which orchestrates central mechanisms that govern cell proliferation, polarity and stem cell fate. To achieve the proposed objectives, a controlled synthetic approach will tailor Wnt ligands on magnetic nanoparticles, combining targeting and magnetic properties in a uniquenanovector. Owing to its chemico-physical features, NanoWnt will enable complete control of the cell signalling, and it will operate in vitro (human cell cultures) and in vivo (the aquatic invertebrateHydra vulgaris), in a dual mode: i) as an activator of the canonical Wnt pathway in those contexts where it is inactive ii) or upon exposure to a magnetic field, as a nanoheater, enabling specific cell ablation by hyperthermia. From a technological point of view, the project will advance basic knowledge on thermal ablation (via magnetic hyperthermia) and holds promises for translational medicine, providing a breakthrough tool to shape cell fate of nanovector receiving cells. Furthermore, combining diverse expertise, CONFINES will offer the applicant advanced and multidisciplinarytraining in the field of nanomaterial synthesis, characterization and functionalisation as well as in hyperthermia technology, which will complement his current skills based on nanobiotechnology and cellular/molecular biology.

 Publications

year authors and title journal last update
List of publications.
2017 Rafael Martín-Rapun, Laura De Matteis, Alfredo Ambrosone, Sonia Garcia-Embid, Lucia Gutierrez, Jesus M. de la Fuente
Targeted Nanoparticles for the Treatment of Alzheimer\'s Disease
published pages: 1927-1952, ISSN: 1381-6128, DOI: 10.2174/1381612822666161226151011
Current Pharmaceutical Design 23/13 2019-06-13

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The information about "CONFINES" are provided by the European Opendata Portal: CORDIS opendata.

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