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Controlling Cell Fate through Smart Nanoheaters

Total Cost €


EC-Contrib. €






 CONFINES project word cloud

Explore the words cloud of the CONFINES project. It provides you a very rough idea of what is the project "CONFINES" about.

confines    thermal    synthesis    expertise    combining    time    complement    bioengineered    basic    promises    cell    forefront    synthetic    aquatic    death    heat    govern    dual    induce    activate    biology    proliferation    uniquenanovector    medicine    achieving    tool    signalling    mechanisms    mode    cellular    operate    smart    skills    characterization    molecular    functionalisation    holds    cultures    orchestrates    physical    owing    diverse    inactive    translational    invertebratehydra    hyperthermia    vivo    cells    stem    shape    fate    wnt    technological    space    nanomaterial    nanoheater    conceived    ligands    fashion    activator    point    demand    chemico    tailor    nanovectorable    nanownt    vulgaris    validate    proof    canonical    polarity    complete    ablation    selective    contexts    multidisciplinarytraining    nanovector    magnetic    vitro    receiving    human    intriguing    central    nanoparticles    fascinating    mediated    breakthrough    view    downstream    nanobiotechnology    exposure   

Project "CONFINES" data sheet

The following table provides information about the project.


Organization address
postcode: 50009

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2018-09-09


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 170˙121.00


 Project objective

Achieving the control of cellular processes is one of the most intriguing challenges in cell biology and medicine. Forefront approaches based on bioengineered nanoparticles might have the potential to target specific cell pathways, thus controlling downstream cell activities in a space and time selective fashion. The present project aims to develop and to validate a smart nanovectorable to activate a specific cell signalling and, on demand, to induce heat mediated cell death of nanovector targeted cells. As proof of concept, CONFINES is conceived to target the Wnt canonical pathway, one of the most studied and fascinating cell signalling, which orchestrates central mechanisms that govern cell proliferation, polarity and stem cell fate. To achieve the proposed objectives, a controlled synthetic approach will tailor Wnt ligands on magnetic nanoparticles, combining targeting and magnetic properties in a uniquenanovector. Owing to its chemico-physical features, NanoWnt will enable complete control of the cell signalling, and it will operate in vitro (human cell cultures) and in vivo (the aquatic invertebrateHydra vulgaris), in a dual mode: i) as an activator of the canonical Wnt pathway in those contexts where it is inactive ii) or upon exposure to a magnetic field, as a nanoheater, enabling specific cell ablation by hyperthermia. From a technological point of view, the project will advance basic knowledge on thermal ablation (via magnetic hyperthermia) and holds promises for translational medicine, providing a breakthrough tool to shape cell fate of nanovector receiving cells. Furthermore, combining diverse expertise, CONFINES will offer the applicant advanced and multidisciplinarytraining in the field of nanomaterial synthesis, characterization and functionalisation as well as in hyperthermia technology, which will complement his current skills based on nanobiotechnology and cellular/molecular biology.


year authors and title journal last update
List of publications.
2017 Rafael Martín-Rapun, Laura De Matteis, Alfredo Ambrosone, Sonia Garcia-Embid, Lucia Gutierrez, Jesus M. de la Fuente
Targeted Nanoparticles for the Treatment of Alzheimer\'s Disease
published pages: 1927-1952, ISSN: 1381-6128, DOI: 10.2174/1381612822666161226151011
Current Pharmaceutical Design 23/13 2019-06-13

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The information about "CONFINES" are provided by the European Opendata Portal: CORDIS opendata.

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