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MechanoSpectrin SIGNED

Dynamic and Mechanical Role of Spectrin in Membrane-CytoskeletonInterplay

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoSpectrin project word cloud

Explore the words cloud of the MechanoSpectrin project. It provides you a very rough idea of what is the project "MechanoSpectrin" about.

networks    resolution    plasticity    cytoskeleton    knock    protein    neurons    group    molecular    forces    platform    sensing    family    mechanisms    act    mechano    multicellular    detrimental    dr    types    resilient    microscopy    context    except    rigidity    neuronal    plan    membrane    conserved    super    elucidate    dynamic    dynamically    mechanosensation    overlooked    unveil    disassemble    evolutionary    connections    mostly    optical    mechanotransduction    filaments    cytoskeletal    poorly    meshwork    interaction    mechanical    spring    exert    perturbations    fibroblasts    surrounding    intermediate    sense    elastic    fibroblast    spreading    microtubule    micro    reacts    tension    shape    patterning    poor    migration    describe    model    substrate    erythrocytes    adapt    eukaryotic    expressed    unknown    resolved    time    engaged    observations    contributes    firstly    gauthier    organisation    tweezers    structural    organisms    spectrin    environment    assemble    maintenance    static    react    cell    techniques    ubiquitously    contribution    actin    axon   

Project "MechanoSpectrin" data sheet

The following table provides information about the project.

Coordinator
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE 

Organization address
address: VIA ADAMELLO 16
city: MILANO
postcode: 20139
website: www.ifom-firc.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) coordinator 168˙277.00

Map

 Project objective

Multicellular organisms have evolved complex mechanisms to sense and adapt to the surrounding environment by dynamically controlling cell shape and exert forces. While the most studied mechanisms are the Actin and Microtubule networks, there is poor understanding of a third system called Intermediate Filaments. In this context, a particularly overlooked mechano-sensing protein is spectrin, a resilient structural platform firstly described to maintain cell shape in erythrocytes and recently proposed to be involved in neuronal plasticity and maintenance of axon rigidity. Spectrin is ubiquitously expressed and the knock-out is detrimental. It is proposed to act as an elastic spring engaged in membrane-cytoskeleton connections, but molecular organisation and dynamic observations are unknown in most eukaryotic cell types. Particularly, is not understood how spectrin-based meshwork assemble-disassemble and react to mechanical perturbations, except from mostly static observations from erythrocytes and neurons. In this proposal, I plan to investigate spectrin dynamic during cell spreading, cell migration and its role in membrane mechanical adaptation. Using fibroblasts, a well characterized model system for membrane and cytoskeletal dynamic studies by Dr. Gauthier’s group, I aim to describe how spectrin dynamically contributes to cell shape changes, cell-substrate interaction and migration. With membrane-tension analysis by optical tweezers, time-resolved super-resolution microscopy, substrate micro-patterning techniques and various mechanical perturbations, I will unveil how spectrin reacts and contributes to mechanosensation and mechanotransduction. Overall, our results in fibroblast will elucidate the poorly understood contribution of Intermediate Filaments during mechanical adaptation and unveil why the spectrin family is evolutionary highly conserved and ubiquitously expressed.

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The information about "MECHANOSPECTRIN" are provided by the European Opendata Portal: CORDIS opendata.

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