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MechanoSpectrin SIGNED

Dynamic and Mechanical Role of Spectrin in Membrane-CytoskeletonInterplay

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoSpectrin project word cloud

Explore the words cloud of the MechanoSpectrin project. It provides you a very rough idea of what is the project "MechanoSpectrin" about.

membrane    spectrin    resilient    environment    engaged    organisms    unknown    exert    mechanical    assemble    optical    fibroblasts    tweezers    organisation    evolutionary    cell    maintenance    unveil    firstly    gauthier    erythrocytes    dr    shape    mechanisms    super    detrimental    static    types    model    meshwork    overlooked    mechano    cytoskeleton    mostly    reacts    ubiquitously    neurons    platform    expressed    adapt    contribution    fibroblast    sensing    mechanotransduction    elastic    actin    plasticity    substrate    react    poor    time    except    networks    migration    microscopy    describe    dynamic    poorly    conserved    surrounding    rigidity    resolution    group    elucidate    microtubule    axon    sense    filaments    multicellular    dynamically    connections    neuronal    micro    plan    disassemble    tension    observations    act    structural    resolved    spreading    patterning    intermediate    perturbations    family    forces    eukaryotic    molecular    cytoskeletal    interaction    spring    knock    contributes    protein    context    techniques    mechanosensation   

Project "MechanoSpectrin" data sheet

The following table provides information about the project.

Coordinator
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE 

Organization address
address: VIA ADAMELLO 16
city: MILANO
postcode: 20139
website: www.ifom-firc.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) coordinator 168˙277.00

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 Project objective

Multicellular organisms have evolved complex mechanisms to sense and adapt to the surrounding environment by dynamically controlling cell shape and exert forces. While the most studied mechanisms are the Actin and Microtubule networks, there is poor understanding of a third system called Intermediate Filaments. In this context, a particularly overlooked mechano-sensing protein is spectrin, a resilient structural platform firstly described to maintain cell shape in erythrocytes and recently proposed to be involved in neuronal plasticity and maintenance of axon rigidity. Spectrin is ubiquitously expressed and the knock-out is detrimental. It is proposed to act as an elastic spring engaged in membrane-cytoskeleton connections, but molecular organisation and dynamic observations are unknown in most eukaryotic cell types. Particularly, is not understood how spectrin-based meshwork assemble-disassemble and react to mechanical perturbations, except from mostly static observations from erythrocytes and neurons. In this proposal, I plan to investigate spectrin dynamic during cell spreading, cell migration and its role in membrane mechanical adaptation. Using fibroblasts, a well characterized model system for membrane and cytoskeletal dynamic studies by Dr. Gauthier’s group, I aim to describe how spectrin dynamically contributes to cell shape changes, cell-substrate interaction and migration. With membrane-tension analysis by optical tweezers, time-resolved super-resolution microscopy, substrate micro-patterning techniques and various mechanical perturbations, I will unveil how spectrin reacts and contributes to mechanosensation and mechanotransduction. Overall, our results in fibroblast will elucidate the poorly understood contribution of Intermediate Filaments during mechanical adaptation and unveil why the spectrin family is evolutionary highly conserved and ubiquitously expressed.

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