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MechanoSpectrin SIGNED

Dynamic and Mechanical Role of Spectrin in Membrane-CytoskeletonInterplay

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoSpectrin project word cloud

Explore the words cloud of the MechanoSpectrin project. It provides you a very rough idea of what is the project "MechanoSpectrin" about.

environment    microtubule    group    filaments    conserved    adapt    super    neurons    mostly    erythrocytes    organisation    molecular    cytoskeletal    evolutionary    spring    mechanical    plan    multicellular    disassemble    except    poorly    meshwork    tension    ubiquitously    dr    eukaryotic    fibroblast    detrimental    knock    organisms    context    mechanosensation    actin    neuronal    unveil    gauthier    connections    resolution    cytoskeleton    mechanotransduction    migration    patterning    overlooked    elastic    mechano    describe    family    interaction    microscopy    reacts    perturbations    poor    micro    fibroblasts    dynamically    time    resilient    forces    model    react    observations    membrane    protein    sense    engaged    platform    shape    surrounding    contribution    mechanisms    dynamic    act    spectrin    structural    intermediate    techniques    plasticity    elucidate    substrate    spreading    axon    networks    resolved    optical    expressed    rigidity    tweezers    contributes    maintenance    cell    unknown    firstly    exert    types    sensing    assemble    static   

Project "MechanoSpectrin" data sheet

The following table provides information about the project.

Coordinator
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE 

Organization address
address: VIA ADAMELLO 16
city: MILANO
postcode: 20139
website: www.ifom-firc.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) coordinator 168˙277.00

Map

 Project objective

Multicellular organisms have evolved complex mechanisms to sense and adapt to the surrounding environment by dynamically controlling cell shape and exert forces. While the most studied mechanisms are the Actin and Microtubule networks, there is poor understanding of a third system called Intermediate Filaments. In this context, a particularly overlooked mechano-sensing protein is spectrin, a resilient structural platform firstly described to maintain cell shape in erythrocytes and recently proposed to be involved in neuronal plasticity and maintenance of axon rigidity. Spectrin is ubiquitously expressed and the knock-out is detrimental. It is proposed to act as an elastic spring engaged in membrane-cytoskeleton connections, but molecular organisation and dynamic observations are unknown in most eukaryotic cell types. Particularly, is not understood how spectrin-based meshwork assemble-disassemble and react to mechanical perturbations, except from mostly static observations from erythrocytes and neurons. In this proposal, I plan to investigate spectrin dynamic during cell spreading, cell migration and its role in membrane mechanical adaptation. Using fibroblasts, a well characterized model system for membrane and cytoskeletal dynamic studies by Dr. Gauthier’s group, I aim to describe how spectrin dynamically contributes to cell shape changes, cell-substrate interaction and migration. With membrane-tension analysis by optical tweezers, time-resolved super-resolution microscopy, substrate micro-patterning techniques and various mechanical perturbations, I will unveil how spectrin reacts and contributes to mechanosensation and mechanotransduction. Overall, our results in fibroblast will elucidate the poorly understood contribution of Intermediate Filaments during mechanical adaptation and unveil why the spectrin family is evolutionary highly conserved and ubiquitously expressed.

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