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MechanoSpectrin SIGNED

Dynamic and Mechanical Role of Spectrin in Membrane-CytoskeletonInterplay

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoSpectrin project word cloud

Explore the words cloud of the MechanoSpectrin project. It provides you a very rough idea of what is the project "MechanoSpectrin" about.

microscopy    mechanisms    disassemble    family    organisms    plan    filaments    neuronal    mechanical    axon    plasticity    meshwork    cell    mechanotransduction    patterning    optical    describe    molecular    adapt    mechanosensation    environment    unveil    sense    connections    spring    surrounding    maintenance    networks    exert    react    overlooked    poorly    actin    types    model    cytoskeletal    expressed    resilient    cytoskeleton    resolution    platform    dynamic    elucidate    microtubule    group    static    neurons    interaction    evolutionary    super    protein    migration    time    conserved    micro    detrimental    except    mechano    unknown    resolved    reacts    organisation    eukaryotic    ubiquitously    context    spectrin    structural    substrate    observations    tweezers    mostly    gauthier    firstly    dynamically    techniques    elastic    erythrocytes    membrane    assemble    act    fibroblast    rigidity    dr    perturbations    shape    engaged    intermediate    poor    contribution    spreading    forces    tension    sensing    multicellular    contributes    fibroblasts    knock   

Project "MechanoSpectrin" data sheet

The following table provides information about the project.

Coordinator
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE 

Organization address
address: VIA ADAMELLO 16
city: MILANO
postcode: 20139
website: www.ifom-firc.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) coordinator 168˙277.00

Map

 Project objective

Multicellular organisms have evolved complex mechanisms to sense and adapt to the surrounding environment by dynamically controlling cell shape and exert forces. While the most studied mechanisms are the Actin and Microtubule networks, there is poor understanding of a third system called Intermediate Filaments. In this context, a particularly overlooked mechano-sensing protein is spectrin, a resilient structural platform firstly described to maintain cell shape in erythrocytes and recently proposed to be involved in neuronal plasticity and maintenance of axon rigidity. Spectrin is ubiquitously expressed and the knock-out is detrimental. It is proposed to act as an elastic spring engaged in membrane-cytoskeleton connections, but molecular organisation and dynamic observations are unknown in most eukaryotic cell types. Particularly, is not understood how spectrin-based meshwork assemble-disassemble and react to mechanical perturbations, except from mostly static observations from erythrocytes and neurons. In this proposal, I plan to investigate spectrin dynamic during cell spreading, cell migration and its role in membrane mechanical adaptation. Using fibroblasts, a well characterized model system for membrane and cytoskeletal dynamic studies by Dr. Gauthier’s group, I aim to describe how spectrin dynamically contributes to cell shape changes, cell-substrate interaction and migration. With membrane-tension analysis by optical tweezers, time-resolved super-resolution microscopy, substrate micro-patterning techniques and various mechanical perturbations, I will unveil how spectrin reacts and contributes to mechanosensation and mechanotransduction. Overall, our results in fibroblast will elucidate the poorly understood contribution of Intermediate Filaments during mechanical adaptation and unveil why the spectrin family is evolutionary highly conserved and ubiquitously expressed.

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