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MechanoSpectrin SIGNED

Dynamic and Mechanical Role of Spectrin in Membrane-CytoskeletonInterplay

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechanoSpectrin project word cloud

Explore the words cloud of the MechanoSpectrin project. It provides you a very rough idea of what is the project "MechanoSpectrin" about.

except    unknown    neurons    context    describe    super    shape    adapt    structural    overlooked    sense    techniques    unveil    axon    membrane    filaments    detrimental    ubiquitously    surrounding    eukaryotic    engaged    erythrocytes    microscopy    spreading    spectrin    substrate    dr    firstly    expressed    resolution    patterning    perturbations    maintenance    model    forces    protein    react    knock    intermediate    plan    actin    organisms    micro    spring    types    molecular    disassemble    assemble    cell    fibroblasts    networks    act    mechanical    plasticity    fibroblast    environment    optical    organisation    cytoskeleton    dynamic    multicellular    conserved    elucidate    mechano    resilient    dynamically    microtubule    migration    tweezers    contributes    observations    neuronal    mostly    static    mechanotransduction    cytoskeletal    poor    exert    connections    poorly    elastic    meshwork    group    rigidity    interaction    resolved    time    contribution    sensing    reacts    evolutionary    tension    gauthier    family    mechanisms    mechanosensation    platform   

Project "MechanoSpectrin" data sheet

The following table provides information about the project.

Coordinator
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE 

Organization address
address: VIA ADAMELLO 16
city: MILANO
postcode: 20139
website: www.ifom-firc.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) coordinator 168˙277.00

Map

 Project objective

Multicellular organisms have evolved complex mechanisms to sense and adapt to the surrounding environment by dynamically controlling cell shape and exert forces. While the most studied mechanisms are the Actin and Microtubule networks, there is poor understanding of a third system called Intermediate Filaments. In this context, a particularly overlooked mechano-sensing protein is spectrin, a resilient structural platform firstly described to maintain cell shape in erythrocytes and recently proposed to be involved in neuronal plasticity and maintenance of axon rigidity. Spectrin is ubiquitously expressed and the knock-out is detrimental. It is proposed to act as an elastic spring engaged in membrane-cytoskeleton connections, but molecular organisation and dynamic observations are unknown in most eukaryotic cell types. Particularly, is not understood how spectrin-based meshwork assemble-disassemble and react to mechanical perturbations, except from mostly static observations from erythrocytes and neurons. In this proposal, I plan to investigate spectrin dynamic during cell spreading, cell migration and its role in membrane mechanical adaptation. Using fibroblasts, a well characterized model system for membrane and cytoskeletal dynamic studies by Dr. Gauthier’s group, I aim to describe how spectrin dynamically contributes to cell shape changes, cell-substrate interaction and migration. With membrane-tension analysis by optical tweezers, time-resolved super-resolution microscopy, substrate micro-patterning techniques and various mechanical perturbations, I will unveil how spectrin reacts and contributes to mechanosensation and mechanotransduction. Overall, our results in fibroblast will elucidate the poorly understood contribution of Intermediate Filaments during mechanical adaptation and unveil why the spectrin family is evolutionary highly conserved and ubiquitously expressed.

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