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Mesoscopic characterization of human white-matter: a computational in-vivo MRI framework

Total Cost €


EC-Contrib. €






 MWMI project word cloud

Explore the words cloud of the MWMI project. It provides you a very rough idea of what is the project "MWMI" about.

habituation    transfer    volume    iron    pain    ratio    magnetization    techniques    unprecedented    conductance    microstructural    innovations    accuracy    mri    combine    sectional    quantitative    model    ill    quality    micro    water    leads    anatomical    density    mechanisms    maps    disciplinary    biophysical    proton    spatial    feasibility    first    spinal    300    resolution    inter    sub    origin    unbiased    physically    nociceptive    artifact    relaxometry    diameter    white    circuit    structure    correlated    fundamental    voxel    surrogate    vivo    resonance    myelin    methodological    axonal    learning    informed    qmri    estimating    integration    correction    mwmi    fiber    standard    mesoscopic    diffusion    speed    unlike    reorganization    conventional    inner    posed    magnetic    partial    restriction    cord    longitudinal    concentration    models    metrics    technique    myelination    performed    mechanism    imaging    whereas    sense    mu    outer    computational    tensor    detect   

Project "MWMI" data sheet

The following table provides information about the project.


Organization address
address: Martinistrasse 52
postcode: 20251

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2017-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The goal of this highly multi-disciplinary and inter-sectional proposal is to develop a novel computational in-vivo MRI technique, namely Mesoscopic White-Matter magnetic resonance Imaging (MWMI). MWMI will measure 5 specific micro-scale metrics at a mesoscopic spatial resolution of about 300 μm: myelin, iron, water concentration, axonal density, and the ratio between inner and outer fiber diameter (g-ratio) - a surrogate measure for its conductance speed. Conventional quantitative MRI (qMRI), such as Diffusion Tensor Imaging, can detect but not determine the origin of microstructural changes, whereas MWMI will both detect microstructural changes and identify their origin (e.g. whether learning leads to axonal reorganization or myelination). To facilitate MWMI, 3 major methodological innovations will be developed: (a) Advanced biophysical models: Unlike existing biophysical models (e.g. axonal diameter model), which are ill posed due to the restriction to one qMRI mechanism, MWMI will combine 4 different qMRI mechanisms (relaxometry, diffusion MRI, magnetization transfer, and proton density imaging) to better condition its models. (b) Spatial integration: Novel physically-informed artifact correction methods will allow spatial integration of high-quality maps from 4 different qMRI techniques with sub-voxel accuracy. (c) Mesoscopic resolution: Unlike standard biophysical models and qMRI, the unprecedented resolution of MWMI will allow estimating micro-scale metrics within the white matter that are unbiased by partial volume effects. The pain circuit, which is a fundamental and well-described sense, will be used to demonstrate the feasibility of MWMI. Longitudinal MWMI be performed to measure micro-scale correlated of nociceptive long-term habituation in the spinal cord, the first and crucial anatomical structure associated with pain.


year authors and title journal last update
List of publications.
2016 Patrick Freund, Karl Friston, Alan J. Thompson, Klaas E. Stephan, John Ashburner, Dominik R. Bach, Zoltan Nagy, Gunther Helms, Bogdan Draganski, Siawoosh Mohammadi, Martin E. Schwab, Armin Curt, Nikolaus Weiskopf
Embodied neurology: an integrative framework for neurological disorders
published pages: 1855-1861, ISSN: 0006-8950, DOI: 10.1093/brain/aww076
Brain 139/6 2019-06-14
2017 Peter Smittenaar, Zeb Kurth-Nelson, Siawoosh Mohammadi, Nikolaus Weiskopf, Raymond J. Dolan
Local striatal reward signals can be predicted from corticostriatal connectivity
published pages: 9-17, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.07.042
NeuroImage 159 2019-06-14
2017 Luke J. Edwards, Kerrin J. Pine, Isabel Ellerbrock, Nikolaus Weiskopf, Siawoosh Mohammadi
NODDI-DTI: Estimating Neurite Orientation and Dispersion Parameters from a Diffusion Tensor in Healthy White Matter
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00720
Frontiers in Neuroscience 11 2019-06-14
2017 Gergely David, Patrick Freund, Siawoosh Mohammadi
The efficiency of retrospective artifact correction methods in improving the statistical power of between-group differences in spinal cord DTI
published pages: 296-307, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.06.051
NeuroImage 158 2019-06-14

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The information about "MWMI" are provided by the European Opendata Portal: CORDIS opendata.

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