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Mesoscopic characterization of human white-matter: a computational in-vivo MRI framework

Total Cost €


EC-Contrib. €






 MWMI project word cloud

Explore the words cloud of the MWMI project. It provides you a very rough idea of what is the project "MWMI" about.

surrogate    magnetization    integration    density    myelination    origin    sub    estimating    tensor    proton    methodological    sense    magnetic    detect    computational    diffusion    axonal    unlike    accuracy    ill    disciplinary    performed    resonance    quality    whereas    learning    metrics    quantitative    qmri    reorganization    speed    inter    pain    longitudinal    restriction    mesoscopic    anatomical    water    models    300    artifact    resolution    sectional    techniques    structure    cord    correction    spatial    unprecedented    model    relaxometry    partial    volume    posed    myelin    correlated    microstructural    ratio    maps    first    mwmi    fundamental    outer    conductance    mu    habituation    feasibility    leads    voxel    combine    biophysical    informed    iron    nociceptive    white    innovations    mechanism    micro    diameter    unbiased    spinal    imaging    standard    circuit    vivo    physically    conventional    inner    mri    concentration    transfer    fiber    mechanisms    technique   

Project "MWMI" data sheet

The following table provides information about the project.


Organization address
address: Martinistrasse 52
postcode: 20251

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2017-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The goal of this highly multi-disciplinary and inter-sectional proposal is to develop a novel computational in-vivo MRI technique, namely Mesoscopic White-Matter magnetic resonance Imaging (MWMI). MWMI will measure 5 specific micro-scale metrics at a mesoscopic spatial resolution of about 300 μm: myelin, iron, water concentration, axonal density, and the ratio between inner and outer fiber diameter (g-ratio) - a surrogate measure for its conductance speed. Conventional quantitative MRI (qMRI), such as Diffusion Tensor Imaging, can detect but not determine the origin of microstructural changes, whereas MWMI will both detect microstructural changes and identify their origin (e.g. whether learning leads to axonal reorganization or myelination). To facilitate MWMI, 3 major methodological innovations will be developed: (a) Advanced biophysical models: Unlike existing biophysical models (e.g. axonal diameter model), which are ill posed due to the restriction to one qMRI mechanism, MWMI will combine 4 different qMRI mechanisms (relaxometry, diffusion MRI, magnetization transfer, and proton density imaging) to better condition its models. (b) Spatial integration: Novel physically-informed artifact correction methods will allow spatial integration of high-quality maps from 4 different qMRI techniques with sub-voxel accuracy. (c) Mesoscopic resolution: Unlike standard biophysical models and qMRI, the unprecedented resolution of MWMI will allow estimating micro-scale metrics within the white matter that are unbiased by partial volume effects. The pain circuit, which is a fundamental and well-described sense, will be used to demonstrate the feasibility of MWMI. Longitudinal MWMI be performed to measure micro-scale correlated of nociceptive long-term habituation in the spinal cord, the first and crucial anatomical structure associated with pain.


year authors and title journal last update
List of publications.
2016 Patrick Freund, Karl Friston, Alan J. Thompson, Klaas E. Stephan, John Ashburner, Dominik R. Bach, Zoltan Nagy, Gunther Helms, Bogdan Draganski, Siawoosh Mohammadi, Martin E. Schwab, Armin Curt, Nikolaus Weiskopf
Embodied neurology: an integrative framework for neurological disorders
published pages: 1855-1861, ISSN: 0006-8950, DOI: 10.1093/brain/aww076
Brain 139/6 2019-06-14
2017 Peter Smittenaar, Zeb Kurth-Nelson, Siawoosh Mohammadi, Nikolaus Weiskopf, Raymond J. Dolan
Local striatal reward signals can be predicted from corticostriatal connectivity
published pages: 9-17, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.07.042
NeuroImage 159 2019-06-14
2017 Luke J. Edwards, Kerrin J. Pine, Isabel Ellerbrock, Nikolaus Weiskopf, Siawoosh Mohammadi
NODDI-DTI: Estimating Neurite Orientation and Dispersion Parameters from a Diffusion Tensor in Healthy White Matter
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00720
Frontiers in Neuroscience 11 2019-06-14
2017 Gergely David, Patrick Freund, Siawoosh Mohammadi
The efficiency of retrospective artifact correction methods in improving the statistical power of between-group differences in spinal cord DTI
published pages: 296-307, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.06.051
NeuroImage 158 2019-06-14

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The information about "MWMI" are provided by the European Opendata Portal: CORDIS opendata.

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