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MEBA

Molecular epidemiology of Bacillus anthracis: novel data and techniques for local surveillance in Tanzania

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MEBA project word cloud

Explore the words cloud of the MEBA project. It provides you a very rough idea of what is the project "MEBA" about.

largely    additionally    baseline    regular    performed    schemes    obtain    fine    world    nucleotide    wildlife    capacity    strains    quantify    surveillance    devastating    carcasses    single    agent    first    molecular    saharan    laboratory    people    perpetuates    culture    typing    biocontainment    genetic    sequencing    risks    bacillus    isolates    local    passive    region    bacterial    environmental    environment    collected    diversity    lack    attacking    differences    tools    epidemiological    circulation    spread    genotyping    poverty    tourism    genomic    genome    anthrax    samples    generate    circulating    links    patterns    income    techniques    africa    resolve    distinguish    organization    diagnostic    disease    tanzania    impacts    livestock    bioinformatic    outbreaks    serengeti    transmission    locus    appropriate    locally    data    reducing    impeded    quality    facilities    causing    scheme    health    sub    agriculture    snps    interface    biosafety    dna    polymorphisms    livelihoods    anthracis   

Project "MEBA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://naturallyspeaking.blog/2016/07/13/episode-43-living-with-anthrax/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-11-02   to  2017-11-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 195˙454.00

Map

 Project objective

Anthrax is described by the World Health Organization as a disease that “perpetuates poverty by attacking not only people’s health but also their livelihoods.” In the Serengeti region of Tanzania, where income is largely based on agriculture and tourism, regular outbreaks of anthrax in both livestock and wildlife have devastating impacts. Understanding and controlling the spread of Bacillus anthracis, the bacterial agent causing anthrax, in this environment is currently impeded by a lack of data on the genetic diversity and appropriate typing schemes to resolve fine-scale genetic differences. I propose to quantify the genomic diversity of B. anthracis in the Serengeti region of Tanzania and to use these data to develop molecular diagnostic and genotyping tools that can be implemented locally to facilitate surveillance. First, whole-genome sequencing will be performed on isolates obtained from wildlife and livestock carcasses and environmental samples collected through passive surveillance. Bioinformatic analyses will enable single nucleotide polymorphisms (SNPs) to be identified that can distinguish among locally-circulating B. anthracis strains and test for epidemiological links between outbreaks. Based on these SNPs, a multi-locus typing scheme will be developed. To further support local laboratory capacity, I will apply recently developed techniques to obtain high quality genomic DNA from environmental samples without the need for bacterial culture, thus greatly reducing the biosafety risks associated with anthrax surveillance in low-biocontainment facilities. This project will generate important baseline information on the diversity and transmission of B. anthracis in the Serengeti. Additionally, facilitating the local implementation of molecular surveillance will eventually allow us to determine the circulation patterns of B. anthracis at the wildlife-livestock interface in Tanzania, providing essential information for anthrax management in sub-Saharan Africa.

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