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MEBA

Molecular epidemiology of Bacillus anthracis: novel data and techniques for local surveillance in Tanzania

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MEBA project word cloud

Explore the words cloud of the MEBA project. It provides you a very rough idea of what is the project "MEBA" about.

impeded    risks    biocontainment    locally    sub    bioinformatic    snps    techniques    quality    fine    lack    strains    culture    differences    appropriate    capacity    schemes    transmission    scheme    local    baseline    patterns    livestock    dna    disease    resolve    africa    health    organization    surveillance    epidemiological    polymorphisms    genome    outbreaks    distinguish    samples    spread    livelihoods    diversity    attacking    additionally    genotyping    agent    facilities    poverty    largely    isolates    links    income    region    serengeti    generate    sequencing    devastating    causing    world    diagnostic    quantify    tourism    laboratory    anthrax    wildlife    data    circulation    anthracis    genomic    environmental    obtain    environment    people    first    molecular    regular    nucleotide    impacts    biosafety    interface    typing    single    tools    reducing    saharan    carcasses    collected    perpetuates    performed    passive    genetic    bacillus    bacterial    tanzania    agriculture    locus    circulating   

Project "MEBA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://naturallyspeaking.blog/2016/07/13/episode-43-living-with-anthrax/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-11-02   to  2017-11-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 195˙454.00

Map

 Project objective

Anthrax is described by the World Health Organization as a disease that “perpetuates poverty by attacking not only people’s health but also their livelihoods.” In the Serengeti region of Tanzania, where income is largely based on agriculture and tourism, regular outbreaks of anthrax in both livestock and wildlife have devastating impacts. Understanding and controlling the spread of Bacillus anthracis, the bacterial agent causing anthrax, in this environment is currently impeded by a lack of data on the genetic diversity and appropriate typing schemes to resolve fine-scale genetic differences. I propose to quantify the genomic diversity of B. anthracis in the Serengeti region of Tanzania and to use these data to develop molecular diagnostic and genotyping tools that can be implemented locally to facilitate surveillance. First, whole-genome sequencing will be performed on isolates obtained from wildlife and livestock carcasses and environmental samples collected through passive surveillance. Bioinformatic analyses will enable single nucleotide polymorphisms (SNPs) to be identified that can distinguish among locally-circulating B. anthracis strains and test for epidemiological links between outbreaks. Based on these SNPs, a multi-locus typing scheme will be developed. To further support local laboratory capacity, I will apply recently developed techniques to obtain high quality genomic DNA from environmental samples without the need for bacterial culture, thus greatly reducing the biosafety risks associated with anthrax surveillance in low-biocontainment facilities. This project will generate important baseline information on the diversity and transmission of B. anthracis in the Serengeti. Additionally, facilitating the local implementation of molecular surveillance will eventually allow us to determine the circulation patterns of B. anthracis at the wildlife-livestock interface in Tanzania, providing essential information for anthrax management in sub-Saharan Africa.

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