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INSPirAUTOR SIGNED

Understanding how Inositol Polyphosphates regulate autophagy and lipid body formation in photosynthetic organisms: crosstalk with TOR signaling.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 INSPirAUTOR project word cloud

Explore the words cloud of the INSPirAUTOR project. It provides you a very rough idea of what is the project "INSPirAUTOR" about.

kinome    potentially    thaliana    insp    kinase    deficient    lipid    metabolic    analytical    organisms    carbon    arabidopsis    plants    nutritional    lineage    productivity    inhibitors    monitor    insights    network    fluctuations    cell    photosynthetic    crops    engineering    levels    inositol    algae    takes    believe    storage    phosphorylation    flux    reserves    unravel    sink    regulating    connection    basic    regulatory    fossil    intersection    elucidation    oils    revealed    signaling    autophagy    goals    biofuel    impacts    sense    benefit    place    relevance    regulators    dependence    conserved    alga    world    stress    model    govern    tools    lipids    poorly    cells    turn    relationship    tor    people    partitioning    modulation    insps    straight    synergistic    humans    mutant    direct    food    green    audience    metabolism    recycling    declining    phosphoproteome    regulation    yields    designed    mechanisms    teach    fuels    networks    effect    polyphosphate    found    reinhardtii    first    economic    chlamydomonas   

Project "INSPirAUTOR" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2021-02-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

Map

 Project objective

The elucidation of regulatory networks that govern cell growth and carbon storage in photosynthetic cells may potentially benefit the world's dependence on the declining reserves of fossil fuels. The growth/carbon sink relationship impacts metabolism, carbon partitioning and productivity but its regulation is poorly understood. Recently, we found a connection between two major cell growth regulators in the model green alga Chlamydomonas reinhardtii. Our findings revealed a synergistic effect between TOR kinase and Inositol polyphosphate (InsP) regulating lipid metabolism and the recycling process of autophagy. Based on the relevance of these results, we aim to find the mechanisms and the conditions in which this intersection takes place within the green lineage. In this sense, we have designed a straight-forward project including different goals. First, we will set novel analytical tools to evaluate the InsP level fluctuations in the presence of new TOR inhibitors and monitor the impact on autophagy flux and lipid metabolism in the model photosynthetic organisms Chlamydomonas reinhardtii and Arabidopsis thaliana. Second, we want to identify the phosphorylation targets of InsPs using Kinome/P-phosphoproteome in a Chlamydomonas InsP-deficient mutant. This analysis will unravel the phosphorylation network of InsP signaling and will provide new insights about the role of InsP in the control of cell growth. Third, we will evaluate InsP levels, autophagy flux and lipid storage under nutritional stress to determine the InsP modulation response in plants and algae. Understanding this signaling pathway will impact metabolic engineering of food and biofuel crops to improve yields of high-value products including oils and lipids. We believe this project will impact a general audience and will help to teach people how basic research can turn into a greater understanding of a process that is conserved in humans and has a direct economic impact.

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The information about "INSPIRAUTOR" are provided by the European Opendata Portal: CORDIS opendata.

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