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INSPirAUTOR SIGNED

Understanding how Inositol Polyphosphates regulate autophagy and lipid body formation in photosynthetic organisms: crosstalk with TOR signaling.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 INSPirAUTOR project word cloud

Explore the words cloud of the INSPirAUTOR project. It provides you a very rough idea of what is the project "INSPirAUTOR" about.

carbon    people    economic    nutritional    analytical    audience    stress    thaliana    basic    benefit    deficient    synergistic    oils    flux    lipids    turn    arabidopsis    recycling    found    fossil    tools    connection    engineering    reserves    inositol    productivity    partitioning    believe    cells    elucidation    straight    polyphosphate    relevance    potentially    takes    designed    networks    conserved    revealed    plants    kinase    organisms    direct    relationship    phosphoproteome    effect    sink    storage    teach    signaling    network    poorly    autophagy    mutant    insights    unravel    fluctuations    declining    monitor    reinhardtii    intersection    yields    regulatory    insps    green    phosphorylation    alga    regulators    fuels    modulation    metabolism    place    impacts    mechanisms    govern    lineage    algae    biofuel    first    lipid    metabolic    food    kinome    sense    goals    inhibitors    cell    regulation    world    tor    model    humans    photosynthetic    regulating    levels    insp    crops    dependence    chlamydomonas   

Project "INSPirAUTOR" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2021-02-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

Map

 Project objective

The elucidation of regulatory networks that govern cell growth and carbon storage in photosynthetic cells may potentially benefit the world's dependence on the declining reserves of fossil fuels. The growth/carbon sink relationship impacts metabolism, carbon partitioning and productivity but its regulation is poorly understood. Recently, we found a connection between two major cell growth regulators in the model green alga Chlamydomonas reinhardtii. Our findings revealed a synergistic effect between TOR kinase and Inositol polyphosphate (InsP) regulating lipid metabolism and the recycling process of autophagy. Based on the relevance of these results, we aim to find the mechanisms and the conditions in which this intersection takes place within the green lineage. In this sense, we have designed a straight-forward project including different goals. First, we will set novel analytical tools to evaluate the InsP level fluctuations in the presence of new TOR inhibitors and monitor the impact on autophagy flux and lipid metabolism in the model photosynthetic organisms Chlamydomonas reinhardtii and Arabidopsis thaliana. Second, we want to identify the phosphorylation targets of InsPs using Kinome/P-phosphoproteome in a Chlamydomonas InsP-deficient mutant. This analysis will unravel the phosphorylation network of InsP signaling and will provide new insights about the role of InsP in the control of cell growth. Third, we will evaluate InsP levels, autophagy flux and lipid storage under nutritional stress to determine the InsP modulation response in plants and algae. Understanding this signaling pathway will impact metabolic engineering of food and biofuel crops to improve yields of high-value products including oils and lipids. We believe this project will impact a general audience and will help to teach people how basic research can turn into a greater understanding of a process that is conserved in humans and has a direct economic impact.

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The information about "INSPIRAUTOR" are provided by the European Opendata Portal: CORDIS opendata.

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