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INSPirAUTOR SIGNED

Understanding how Inositol Polyphosphates regulate autophagy and lipid body formation in photosynthetic organisms: crosstalk with TOR signaling.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 INSPirAUTOR project word cloud

Explore the words cloud of the INSPirAUTOR project. It provides you a very rough idea of what is the project "INSPirAUTOR" about.

poorly    mutant    tools    polyphosphate    lineage    impacts    turn    people    analytical    basic    insights    modulation    designed    network    revealed    synergistic    regulating    first    reserves    benefit    inositol    monitor    kinase    intersection    mechanisms    alga    unravel    productivity    world    partitioning    relevance    cell    connection    food    yields    algae    regulation    audience    fossil    humans    sense    effect    believe    storage    relationship    arabidopsis    takes    declining    lipids    stress    biofuel    insp    plants    govern    phosphoproteome    lipid    economic    elucidation    oils    thaliana    place    conserved    chlamydomonas    kinome    regulatory    regulators    potentially    metabolism    deficient    organisms    fluctuations    fuels    reinhardtii    insps    phosphorylation    engineering    metabolic    goals    crops    teach    autophagy    photosynthetic    green    levels    inhibitors    carbon    cells    networks    nutritional    dependence    found    direct    sink    tor    recycling    signaling    flux    straight    model   

Project "INSPirAUTOR" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2021-02-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

Map

 Project objective

The elucidation of regulatory networks that govern cell growth and carbon storage in photosynthetic cells may potentially benefit the world's dependence on the declining reserves of fossil fuels. The growth/carbon sink relationship impacts metabolism, carbon partitioning and productivity but its regulation is poorly understood. Recently, we found a connection between two major cell growth regulators in the model green alga Chlamydomonas reinhardtii. Our findings revealed a synergistic effect between TOR kinase and Inositol polyphosphate (InsP) regulating lipid metabolism and the recycling process of autophagy. Based on the relevance of these results, we aim to find the mechanisms and the conditions in which this intersection takes place within the green lineage. In this sense, we have designed a straight-forward project including different goals. First, we will set novel analytical tools to evaluate the InsP level fluctuations in the presence of new TOR inhibitors and monitor the impact on autophagy flux and lipid metabolism in the model photosynthetic organisms Chlamydomonas reinhardtii and Arabidopsis thaliana. Second, we want to identify the phosphorylation targets of InsPs using Kinome/P-phosphoproteome in a Chlamydomonas InsP-deficient mutant. This analysis will unravel the phosphorylation network of InsP signaling and will provide new insights about the role of InsP in the control of cell growth. Third, we will evaluate InsP levels, autophagy flux and lipid storage under nutritional stress to determine the InsP modulation response in plants and algae. Understanding this signaling pathway will impact metabolic engineering of food and biofuel crops to improve yields of high-value products including oils and lipids. We believe this project will impact a general audience and will help to teach people how basic research can turn into a greater understanding of a process that is conserved in humans and has a direct economic impact.

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The information about "INSPIRAUTOR" are provided by the European Opendata Portal: CORDIS opendata.

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